Yihan LIN-Center For Life Sciences

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Center PI

Yihan LIN

Research interest: single-cell techniques、noise and dynamics、phase separation、epigenetic regulation、feedback loops、homeostasis and differentiation、feedback loops

Office: Rm.229, Lui Che Woo Building, Peking University

Research Area:

Our lab focuses on dissecting the regulatory mechanisms underlying cell state heterogeneity and cell fate control in disease-relevant cell types, including stem cells, immune cells, and cancer cells. By combining new quantitative single-cell tools with systems and synthetic biology approaches, we are investigating key determining factors for cell state heterogeneity and cell fate control. By doing so, we aim to achieve a deeper understanding of key biological processes including development, immunity and disease at the single-cell level. Ultimately, these efforts will allow us to design new therapeutics using drug combinations or synthetic gene circuits.

Selected Publications:

1. Lingfeng Xue, Yan Wu, Yihan Lin*. Dissecting and improving gene regulatory network inference using single-cell transcriptome data. Genome Research, 2023, doi:10.1101/gr.277488.122.

2. Jianhan Zhang, Xu Han, Liang Ma, Shuhui Xu, Yihan Lin*. Deciphering a global source of non-genetic heterogeneity in cancer cells. Nucleic Acids Research, 2023, gkad666.

3. Wen Huang, Wei Lin, Baoqiang Chen, Jianhan Zhang, Peifen Gao, Yingying Fan, Yihan Lin*, Ping Wei*, NFAT and NF-κB dynamically co-regulate TCR and CAR signaling responses in human T cells, Cell Reports, 2023, 42(7):112663.

4. Jiegen Wu#, Baoqiang Chen^#, Yadi Liu, Liang Ma, Wen Huang, Yihan Lin*, Modulating gene regulation function by chemically controlled transcription factor clustering, Nature Communications, 2022, 13:2663.

5. Yan Wu^#, Lingfeng Xue^#, Huang Wen^#, Minghua Deng, Yihan Lin*, Profiling transcription factor activity dynamics using intronic reads in time-series transcriptome data, PLOS Computational Biology, 2022, 18(1): e1009762.

6. Liang Ma, Zeyue Gao, Jiegen Wu, Bijunyao Zhong, Yuchen Xie, Wen Huang, Yihan Lin*. Co-condensation between transcription factor and coactivator p300 modulates transcriptional bursting kinetics. Molecular Cell, 2021, 81:1682-1697.

7. Yan Wu, Jiaqi Wu, Minghua Deng, Yihan Lin*. Yeast cell fate control by temporal redundancy modulation of transcription factor paralogs. Nature Communications, 2021, 12(1):3145.

8. Jiegen Wu, Xu Han, Haotian Zhai, Tingyu Yang, Yihan Lin*, Evidence for rate-dependent filtering of global extrinsic noise by biochemical reactions in mammalian cells, Molecular Systems Biology, 2020, 16: e9335.

9. Jianhan Zhang^#, Xu Han^#, Yihan Lin*, Dissecting the regulation and function of ATP at the single-cell level, PLOS Biology, 2018, 16(12): e3000095 (Primer).

10. Bingteng Xie, Yang Pu, Fan Yang, Wei Chen, Wei Yue, Jihong Ma, Na Zhang, Yuening Jiang, Jiegen Wu, Yihan Lin, Xin Liang, Chu Wang, Peng Zou*, Mo Li*, Proteomic mapping and targeting of mitotic pericentriolar material in tumors bearing centrosome amplification, Cancer Research, 2022, 82 (14): 2576–2592.

11. Rosa Martinez-Corral, Elba Raimundez, Yihan Lin, Michael B Elowitz, Jordi Garcia-Ojalvo*, Self-amplifying pulsatile protein dynamics without positive feedback, Cell Systems, 2018, 7(4): 453-462.

12. Jin Park, Marta Dies, Yihan Lin, Sahand Hormoz, Stephanie E. Smith-Unna, Sofia Quinodoz, María Jesús Hernández-Jiménez, Jordi Garcia-Ojalvo^#, James C.W. Locke^#, Michael B. Elowitz^#, Molecular time sharing through dynamic pulsing in single cells, Cell Systems, 2018, 6(2): 216-229.

13. Yuval Yifat, Nishant Sule, Yihan Lin, Norbert F. Scherer, Analysis and correction of errors in nanoscale particle tracking using the Single-pixel interior filling function (SPIFF) algorithm, Scientific Reports, 2017, 7, 16553.

# equal contributions

* corresponding author

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