Xuemei Chen

Email: xuemei.chen(at)pku(dot)edu(dot)cn

Research interests：

Xuemei Chen's lab is interested in understanding processes that occur at the RNA level and their molecular as well as biological impacts. Major areas of focus include RNA modifications such as pseudouridylation and the 5' capping by cellular metabolites, and small RNAs.

Selected publications:

(* corresponding author)

1. Hao Hu*, Qiyue Zhang, Xuan Ma, Hsu-Feng Chu, Han Wang, Yiwen Guo, Yuze Bai, Qianyu Wang, Zehao Li, Jiayi Zhao, Huiyuan Lin, Chenjiang You, Xing Li, Liang Tong, Xuemei Chen*. (2026). Accurate Quantification and Transcriptome Profiling Reveal Abundant, Dynamic, and Translatable RNAs Capped with Dephospho-CoA. Nature Biotechnology, 10.1038/s41587-026-03040-4.

2. Xufeng Wang, Brandon H. Le, Ye Xu, Penglin Sun, Min Qiu, Yao Zhao, Lin Li, Min Wang, Kestrel Rogers, Yu Yu, Zhanyuan Zhang, Huixia Shou, Wenbo Ma and Xuemei Chen*. (2026). Soybean RNA polymerases IV and V repress defense response genes and plant immunity. Plant Cell, 10.1093/plcell/koag023.

3. Yu Yu*, Han Wang, Chenjiang You, and Xuemei Chen*. (2026). Plant microRNA maturation and function. Nat. Rev. Mol. Cell Biol. 27, 55-70.

4. Xufeng Wang, Dongli Yu, Jiancheng Yu, Hao Hu, Runlai Hang, Zachary Amador, Qi Chen, Jijie Chai, and Xuemei Chen*. (2024). Toll/interleukin-1 receptor (TIR) domain-containing proteins exhibit deNAMing activity towards NAD-capped RNAs. Nature Comm. 15: 2261.

5. Xuemei Chen* and Oded Rechavi*. (2021). Plant and animal small RNA communications between cells and organisms. Nature Rev. Mol. Cell Biol. 23, 85–203. https://doi.org/10.1038/s41580-021-00425-y.

6. Hao Hu, Nora Flynn, Hailei Zhang, Chenjiang You, Runlai Hang, Xufeng Wang, Huan Zhong, Zhulong Chan, Yiji Xia*, and Xuemei Chen*. (2021). SPAAC-NAD-seq, a sensitive and accurate method to profile NAD+-capped transcripts. PNAS 118 (13) e2025595118.