Junyu Xiao

Email: junyuxiao(at)pku(dot)edu(dot)cn；

Research area：Molecular mechanism of immune molecules

Research Interests

We seek to elucidate the molecular mechanisms governing immunoglobulins (antibodies), with particular emphasis on their interactions with cognate receptors, binding partners, as well as pathogen-derived molecules. In parallel, we investigate the complement system and its underlying molecular processes. Through these studies, we aim to generate mechanistic insights that will inform the development of innovative therapeutic strategies targeting these molecules and pathways.

Selected Publications:

1. Li, Y., Wang, G., Li, N., Wang, Y., Zhu, Q., Chu, H., Wu, W., Tan, Y., Yu, F., Su, X.D.,      Gao, N., Xiao, J.* (2020). Structural insights into      immunoglobulin M. Science 367:1014-1017.

2. Wang, Y., Wang, G., Li, Y., Zhu, Q., Shen, H., Gao, N., Xiao, J.* (2020). Structural insights into secretory immunoglobulin A and its      interaction with a pneumococcal adhesin. Cell Research      30:602-609.

3. Li, Y., Shen,H., Zhang, R., Ji, C., Wang, Y., Su, C., Xiao, J.* (2023). Immunoglobulin M      Perception by FcμR. Nature 615:907-912.

4. Ji, C., Shen, H., Su, C., Li, Y., Chen,      S., Sharp, T.H., Xiao, J.* (2023). Plasmodium falciparum has evolved multiple mechanisms to hijack human immunoglobulin M.      Nature Communications 14:2650.

5. Wang, Y., Su, C., Ji, C., Xiao, J.* (2024). CD5L      associates with IgM via the J chain. Nature Communications 15:8397.

6. Deng,  M., Du, S.*, Hou, H., Xiao, J.* (2024). Structural insights      into the high-affinity IgE receptor FcεRI complex. Nature 633:952-959.

7. ZhangR, Ji C, Li S, Li N, Gao N*,      Xiao J*.      (2025) Xenopus IgX informs      engineering strategies of IgM and IgG hexamers. Sci Adv. 11:eaea3737.

8. Chen S, Li S, Zhang Z, Xiao J*. (2026) Human FcRL5      is an Fc receptor that simultaneously engages two IgGs. Sci Adv. 12:eaeb8865.

9. Jia H, Yang X, Zhao MH*,      Tan Y*,      Xiao J*. (2026) Complement C3 recognition by C3      convertases. Sci Adv. 12:eadz5404.

10. Deng, M., Du, S.*, Hou, H., Xiao, J.* (2026). Structure of the IgY-FcRY complex and its comparison with IgG-FcRn. Structure 34:893-900.e3.