Zhe Zhang

Email：zzhang01（at）pku（dot）edu（dot）cn

Research Area:

1. Molecular mechanisms of transmembrane transport of neurotransmitters and key metabolic molecules;

2. Signaling regulatory mechanisms of cell proliferation, differentiation, and programmed cell death;

3. Structure-based drug design and screening.

Selected Publications：

1. Dong Zhou^#, Yang Zhang^#, Nanhao Chen^#, Shitang Huang, Chen Song^*, and Zhe Zhang^*; Structural basis of G6P/Pi transport and inhibition in SLC37A4; Nat. Struct. Mol. Biol.; 2026, 33(1): 123-133.

2. Dong Zhou, Nanhao Chen, Shitang Huang, Chen Song, and Zhe Zhang^*; Mechanistic insights into the acetyl-CoA recognition by SLC33A1; Cell Discov.; 2025, 11(1): 36.

3. Yanyi Song^#, Shuyi Jian^#, Junlin Teng, Pengli Zheng^*, and Zhe Zhang^*; Structural basis of human VANGL-PRICKLE interaction; Nat. Commun.; 2025, 16(1):132.

4. Yang Zhang^#, Fei Dai^#, Nanhao Chen^#, Dong Zhou, Chia-Hsueh Lee^*, Chen Song^*, Yixiao Zhang^*, and Zhe Zhang^*; Structural insights into VAChT neurotransmitter recognition and inhibition; Cell Res.; 2024, 34(9): 665-668.

5. Yu Dang^#, Tianyi Zhang^#, Shabareesh Pidathala^#, Guopeng Wang^#, Yijie Wang^#, Nanhao Chen^#, Chen Song, Chia-Hsueh Lee^*, and Zhe Zhang^*; Substrates and drug recognition mechanisms of SLC19A3; Cell Res.; 2024, 34(6): 458-461.

6. Shabareesh Pidathala^#, Shuyun Liao^#, Yaxin Dai^#, Xiao Li, Changkun Long, Chi-Lun Chang, Zhe Zhang^*, and Chia-Hsueh Lee^*; Mechanisms of neurotransmitter transport and drug inhibition in human VMAT2; Nature; 2023, 623(7989): 1086-1092.

7. Xue Bai^#, Pengyu Sun^#, Xinghao Wang^#, Changkun Long^#, Shuyun Liao^#, Song Dang, Shangshang Zhuang, Yongtao Du, Xinyi Zhang, Nan Li, Kangmin He^*, and Zhe Zhang^*; Structure and dynamics of the EGFR/HER2 heterodimer; Cell Discov.; 2023, 9(1): 18.

8. Yu Dang, Dong Zhou, Xiaojuan Du, Hongtu Zhao, Chia-Hsueh Lee, Jing Yang, Yijie Wang, Changdong Qin, Zhenxi Guo, and Zhe Zhang^*; Molecular mechanism of substrate recognition by folate transporter SLC19A1; Cell Discov.; 2022, 8(1): 141.

9. Zelin Duan^#, Xuezhen Lin^#, Lixia Wang^#, Qiuxin Zhen, Yuefeng Jiang, Chuxin Chen, Jing Yang, Chia-Hsueh Lee, Yan Qin, Ying Li, Bo Zhao^*, Jianchuan Wang^*, and Zhe Zhang^*; Specificity of TGF-β1 signal designated by LRRC33 and integrin αVβ8; Nat. Commun.; 2022, 13(1): 4988.

10. Yuefeng Jiang, Tingting Liu, Chia-Hsueh Lee, Qing Chang, Jing Yang^*, and Zhe Zhang^*; The NAD⁺-mediated self-inhibition mechanism of pro-neurodegenerative SARM1; Nature; 2020, 588(7839): 658-663.