Hang Hubert Yin
Email：yin_hang@tsinghua.edu.cn
Research Area:
Chemical Biology,Drug Discovery
Professor Hang Hubert Yin was born in Beijing in 1976. After studying for a bachelor's degree at Peking University, he received his PhD from Yale University in 2004 under the supervision of Professor Andrew Hamilton and then spent a post-doctoral period at the University of Pennsylvania School of Medicine with Professor William DeGrado. In 2018, Professor Yin joined the School of Pharmaceutical Sciences at Tsinghua University as a founding Deputy Dean. Prior to joining Tsinghua, he was a tenured faculty member of the University of Colorado Boulder.
His research interests lie at the interface of chemistry, biology, and engineering with particular focuses on structure-based drug design, extracellular vesicles, cell signaling biochemistry, biotechnology development, and membrane protein simulations. Professor Yin is a recipient of many accolades for his research in chemical biology and drug discovery, including the Wu Jieping-Paul Janssen Medical & Pharmaceutical Award, Outstanding Contribution Award of the China Pharmaceutical Development Award, American Chemical Society David W. Robertson Award for Excellence in Medicinal Chemistry, OKeanos-CAPA Senior Investigator Award, National Science Fund for Distinguished Young Scholars, Beijing Outstanding Young Scientist, CAPA Distinguished Junior Faculty Award, NSF CAREER Award, AACR Gertrude B. Elion Cancer Research Award, Sidney Kimmel Scholars Award, and HHMI Collaborative Innovation Award among others. Professor Yin’s is currently serving as a member of the Academic Committee of Tsinghua University, an advisor of the Chinese Society of Extracellular Vesicles (CSEV), the Editor-in-Chief of Bioorganic and Medicinal Chemistry Letters, the Editor-in-Chief of the Journal of Extracellular Vesicles, and an advisory board member of Cell Chemical Biology.
Lab website:
http://www.yinlab-tsinghua.cn/
Selected publications in last 5 years (H-Index= 65, citations>28,000)：
1.Li, H; Zhang, Y; Gao S; *Yin, H. “T cell-intrinsic cGAS-CTCF regulation maintains regulatory T cell development and function”, Cell Rep. 2025, 44,116302.
2.Shen, S.; *Yin, H.“E2-UbR74G Strategy Reveals E2-Specific Ubiquitin Conjugation Profiles in Live Cells”, Nat. Chem. Biol. 2025, 21, 1089-1099.
3.Zhou, Y.; Zhang, X.; *Yin, H.“A Site-Specific Photo-Crosslinking Proteomics Approach Provides Insights into Non-Canonical Pyroptotic Caspase-4 Substrates”, Angew Chem Int Ed Engl. 2025, 12:e202501535.
4.Zhang,Y; Li, H; Hao, Y; Chen, X; Hang Yin*. EGR2 O-GlcNAcylation orchestrates protumoral macrophages development to limit CD8+ T Cell antitumor response. Cell Chemical Biology.2025, 32,809-825.e7 (cover article).
5.Jin, Y.;Sun, G.;Chen, B.;Feng, S.;Tang, M.;Wang, H.;Zhang, Y.;Wang, Y.;An, Y.; Xiao, Y.;Liu, Z.;Liu, P.;Tian, Z.; *Yin, H.;Zhang, S. & Luan, X.“Delivering miR-23b-3p by small extracellular vesicles to promote cell senescence and aberrant lipid metabolism”, BMC Biol. 2025 Feb 11;23(1):41.
6.He, P.;Wen, C.;Zhang, X.; *Yin, H. “Discovery of a Novel CRBN-Recruiting cGAS PROTAC Degrader for the Treatment of Ulcerative Colitis”, J Med Chem. 2025 Mar 13;68(5):5551-5572.
7.Wang, J.; Zhong, X.; Liao, C.; Zhang, Y.; Shen, S.; Zhang, R.; Li, G.; *Yin, H.“MyD88 self-assembles into supramolecular filaments to amplify NF-kB signaling”, Fundamental Res. 2025 Feb.
8.Wang, M.; Chen, H.; Zhang, T.; Zhang, Z.; Xiang, X.; Gao, M.; Guo, Y.; Jiang, S.; Yin, K.; Chen, M.; Huang, J.; Zhong, X.; Ohto, M.; Li, J.; Shimizu, T.; *Yin, H. “Targeting Toll-Like Receptor 7 as a Therapeutic Development Strategy for Systemic Lupus Erythematosus”, Acta Pharm. Sin. B 2024, 14, 4899-4913s (cover article).
9.Kadoch, C.; Sheltzer, J. M.; Yin, H. “The Next Nobel Prize in Chemistry or in Physiology or Medicine”, Cell Chem. Biol. 2024, 31, 1566-1567.
10.Jiang, Y. Y.; Yan, S. T.; Zhang, S. Z.; Wang, M.; Diao, W. M.; Li, J.; Fang, X. M.; *Yin, H. “Discovery of Pyrazolo[1,5-a]pyrimidine Derivatives Targeting TLR4-TLR4∗ Homodimerization via AI-Powered Next-Generation Screening”, Eur. J. Med. Chem. 2024, 280:116945.
11.Tang, Q.; *Yin, H. “Pyridine-Based Small Molecule Inhibitors of SARM1 Alleviate Cell Death Caused by NADase Activity”, Chem. Comm. 2024, 60, 8724-8727.
12.Li, L.; Wang, J.; Zhong, X.; Jiang, Y.; Pei, G.; Yang, X.; Zhang, K.; Shen, S.; Jin, X.; Sun, G.; Su, C.; Chen, S.; *Yin, H. “ADP-Hep-Induced Liquid Phase Condensation of TIFA-TRAF6 Activates ALPK1/TIFA-Dependent Innate Immune Responses”, Research (Washington, D.C.) 2024, 7, e0315.
13.Su, C.; Cheng, T.; Huang, J.; Zhang, T.; *Yin, H. “4-Octyl Itaconate Restricts STING Activation by Blocking Its Palmitoylation”, Cell Rep. 2023, 42, e113040.
14.Jin, X.; Xia, T.; Luo, S.; Zhang, Y.; Xia, Y.; *Yin, H. “Exosomal Lipid PI4P Regulates Small Extracellular Vesicle Secretion by Modulating Intraluminal Vesicle Formation”, J. Extracell. Vesicles 2023, 12, 12319.
15.Liang, J.; *Yin, H. “STAM Transports STING Oligomers into Extracellular Vesicles Down-Regulating the Innate Immune Response”, J. Extracell. Vesicles 2023, 12, e12316.
16.*Yin, H.; Fan, C.; Huang, Y.; *Chen, G. “Innovative Chemistry Research Driven by Medicine”, Fundamental Res. 2023, 3, 479-480.
17.Zhao, X.; Liang, J.; Chen, Z.; Jian, R.; Qian, Y.; Wang, Y.; Guo, Z.; Zhang, W.; Zhang, Y.; Yin, H.; Xia, Y. “sn-1 Specificity of Lysophosphatidylcholine Acyltransferase-1 Revealed by a Mass Spectrometry-Based Assay”, Angew. Chem. Int. Ed. 2023, 62, e202215556.
18.Shi, S.; Yang, X.; Hou, Y.; Jin, X.; Guo, L.; Zhou, Y.; Zhang, C.; *Yin, H. “USP15 Promotes cGAS Activation through Deubiquitylation and Liquid Condensation”, Nucleic Acid Res. 2022, 50, 11093-11108.
19.Li, Y.; Pu, D.; Huang, J.; Zhang, Y.; *Yin, H. “Protein Phosphatase 1 Regulates Phosphorylation of Gasdermin D and Pyroptosis”, Chem. Comm. 2022, 58, 11965-11968.
20.Shi, S.; Yang, X.; Liu, Y.; Li, H.; Chu, H.; Li. G.; *Yin, H. “ZDHHC18 Negatively Regulates cGAS-Mediated Innate Immunity Through Palmitoylation”, EMBO J. 2022, 41, e109272.
21.Yang, X.; Shi, S.; Shen, S.; Li, H.; Su, C.; *Yin, H. “MARCH8 Attenuates cGAS-Mediated Innate Immune Responses Through Ubiquitylation”, Sci. Signal. 2022, 15, eabk3067. (highlighted in “This Week in Science” Science 2022, 376, 593) (cover article).
22.Yang, Y.; Csakai, A.; Jiang, S.; Smith, C.; Tanji, H.; Huang, J.; Jones, T.; Sakaniwa, K; Broadwell, L.; Shi, C.; Soti, S.; Ohto, U.; Fang, Y.; Shen, S.; Deng, F.; Shimizu, T.; *Yin, H. “Tetrasubstituted Imidazoles as Incognito Toll-like Receptor 8 A(nta)gonists”, Nat. Commun. 2021, 12, 4351(featured in the Editor’s Highlights to showcase among the 50 best papers in Organic Chemistry and Chemical Biology).
23.Huang, J.; Yuan, Y.; Zhao, N.; Pu, D.; Tang, Q.; Zhang, S.; Luo, S.; Yang, X.; Wang, N.; Xiao, Y.; Zhang, T.; Liu. Z.; Sakata-Kato, Y.; Hirata, K.; *Jiang, X.; *Kato, N.; *Yan, N.; *Yin, H. “Orthosteric-Allosteric Dual Inhibitors of PfHT1 as Selective Anti-Malarial Agents”, Proc. Natl. Acad. Sci. U. S. A. 2021, 118, e2017749118.
24.Jiang, X.; Yuan, Y.; Huang, J.; Zhang, S.; Luo, S.; Wang, N.; Pu, D.; Zhao, N.; Tang, Q.; Hirata, K.; Yang, X.; Jiao, Y.; Sakata-Kato, Y.; Wu, J.; Yan, C.; Kato, N.; *Yin, H.; *Yan, N. “Structural Basis for Blocking Sugar Uptake into the Malaria Parasite Plasmodium falciparum”, Cell 2020, 183, 258-268.
