Wei Wang
EMAIL：oneway1985（at）pku（dot）edu（dot）cn
Home page:https://www.bio.pku.edu.cn/en/index/index/by_speciality_detail/cid/70/id/60.html
Research area：Spatiotemporal regulation of plant stress responses, membraneless organelles, plant circadian clock
Research interest：
The overarching goal of the laboratory is to elucidate the spatiotemporal regulatory mechanisms by which plants orchestrate stress responses—a central question for safeguarding crop yield stability and agricultural resilience under accelerating climate variability.
We tackle this question from two intersecting perspectives:
(1) Spatial dimension—rapid subcellular reorganization via biomolecular condensates. Dynamic, phase-separation–driven membraneless organelles (biomolecular condensates) undergo stimulus-induced assembly/disassembly on fast timescales, creating localized micro-environments that amplify and compartmentalize stress signals and execute efficient, spatially coordinated responses at the subcellular level.
(2) Temporal dimension—circadian gating of whole-plant defense programs. The circadian clock system provides an endogenous, organism-wide temporal framework that gates the activation of distinct stress-response modules, enabling the plant to optimize when each response is engaged and how much resource is allocated—striking a dynamic trade-off between defense commitment and growth maintenance.
Selected Publications:
1.Wang, S. et al. Discovery and heterologous reconstitution of a plant noncanonical quasi-circadian gene regulatory network. Cell (2026). https://doi.org/https://doi.org/10.1016/j.cell.2026.04.033
2 Wang, X. et al. Hijacking the host clock: a nematode effector antagonizes soybean circadian defense and translation control. Adv Sci (Weinh), e18591 (2026). https://doi.org/10.1002/advs.202518591
3 Zhao, S. et al. Duet between stress granules and glutathionylation regulates cytosolic redox state to maintain proteostasis in Arabidopsis. Molecular Plant 19, 606-628 (2026). https://doi.org/https://doi.org/10.1016/j.molp.2025.12.018
4 Xie, Z. et al. Proteasome resides in and dismantles plant heat stress granules constitutively. Molecular Cell 84, 3320-3335.e3327 (2024). https://doi.org/10.1016/j.molcel.2024.07.033
5 Xie, Z. et al. Phenolic acid-induced phase separation and translation inhibition mediate plant interspecific competition. Nature Plants 9, 1481-1499 (2023). https://doi.org/10.1038/s41477-023-01499-6
6 Chen, C. et al. Aptamer-based nanointerferometer enables amplification-free ultrasensitive detection and differentiation of SARS-CoV-2 variants. Analytica Chimica Acta 1260, 341207 (2023). https://doi.org/https://doi.org/10.1016/j.aca.2023.341207
7 Li, M. et al. Comprehensive mapping of abiotic stress inputs into the soybean circadian clock. Proceedings of the National Academy of Sciences of the United States of America 116, 23840-23849 (2019). https://doi.org/10.1073/pnas.1708508116
8 Chen, C. et al. Development of a structure-switching aptamer-based nanosensor for salicylic acid detection. Biosensors and Bioelectronics 140, 111342 (2019). https://doi.org/https://doi.org/10.1016/j.bios.2019.111342
9 Zhou, M. et al. Redox rhythm reinforces the circadian clock to gate immune response. Nature 523, 472-476 (2015). https://doi.org/10.1038/nature14449
10 Wang, W. et al. Timing of plant immune responses by a central circadian regulator. Nature 470, 110-114 (2011). https://doi.org/10.1038/nature09766
