Yunlong Cao
Email：yunlongcao@pku.edu.cn
Homepage：https://yunlongcaolab.com/
Research Interests：
Cao Lab investigates humoral immunity and antibodies at single-cell and molecular level. Our research interests include the following aspects:
1.Antibody response, immune escape and immune imprinting in infectious diseases;、
2.Development of broad-spectrum antibody therapeutics and vaccines;
3.Deciphering the relationship between targeting epitopes and functions of antibodies for various antigens;
4.Computational and machine learning methods for modeling antibody-antigen interaction.
Selected publications:
1. F. Jian#, J. Wang#, A. Yisimayi#, W. Song#, Y. Xu#, X. Chen, X. Niu, S. Yang, Y. Yu, P. Wang, H. Sun, L. Yu, J. Wang, Y. Wang, R. An, W. Wang, M. Ma, T. Xiao, Q. Gu, F. Shao, Y. Wang, Z. Shen, R. Jin, Y. Cao*, Evolving antibody response to SARS-CoV-2 antigenic shift from XBB to JN.1. Nature. 637: 921-929 (2024).
2. A. Yisimayi#, W. Song#, J. Wang#, F. Jian#, Y. Yu#, X. Chen#, Y. Xu#, S. Yang, X. Niu, T. Xiao, J. Wang, L. Zhao, H. Sun, R. An, N. Zhang, Y. Wang, P. Wang, L. Yu, Z. Lv, Q. Gu, F. Shao, R. Jin, Z. Shen, X. S. Xie, Y. Wang & Y. Cao*, Repeated Omicron exposures override ancestral SARS-CoV-2 immune imprinting. Nature. 625: 148-156. (2024).
3.Y. Cao*#, F. Jian#, J. Wang#, Y. Yu#, W. Song#, A. Yisimayi, J. Wang, R. An, X.Chen, N. Zhang, Y. Wang, P. Wang,L. Zhao, H. Sun, L. Yu, S. Yang, X. Niu, T. Xiao, Q. Gu, F. Shao, X. Xiao, Y. Xu, R. Jin, Z. Shen, Y. Wang* & X.S. Xie*, Imprinted SARS-CoV-2 humoral immunity induces convergent Omicron RBD evolution. Nature. 614: 21-529. (2023).
4.Y. Cao*#, A. Yisimayi#, F. Jian#, W. Song#, T. Xiao#, L. Wang#, S. Du#, J. Wang#, Q. Li#, X. Chen#, Y. Yu#, P. Wang,Z. Zhang, P. Liu, R. An, X. Hao, Y. Wang, J. Wang, R. Feng, H. Sun, L. Zhao, W. Zhang, D. Zhao, J. Zheng, L. Y,C. Li, N. Zhang, R. Wang, X. Niu, S. Yang, X. Song, Y. Chai, Y. Hu, Y. Shi, L. Zheng, Z. Li, Q. Gu, F. Shao, W.Huang, R. Jin, Z. Shen*, Y. Wang*, X. Wang*, J. Xiao* & X. S. Xie*, BA.2.12.1, BA.4 and BA.5 escape antibodies elicited by Omicron infection. Nature. 608: 593-602. (2022).
5.Y. Cao*#, J. Wang#, F. Jian#, T. Xiao#, W. Song#, A. Yisimayi#, W. Huang#, Q. Li, P. Wang, R. An, J. Wang, Y. Wang, X. Niu, S. Yang, H. Liang, H. Sun, T. Li, Y. Yu, Q. Cui, S. Liu, X. Yang, S. Du, Z. Zhang, X. Hao, F. Shao,R. Jin, X. Wang*, J. Xiao*, Y. Wang* & X. S. Xie*, Omicron escapes the majority of existing SARS-CoV-2 neutralizing antibodies. Nature. 602: 657-663. (2022).
6.Y. Cao#, B. Su#, X. Guo#, W. Sun#, Y. Deng#, L. Bao#, Q. Zhu, X. Zhang, Y. Zheng, C. Geng, X. Chai, R. He, X. Li,Q. Lv, H. Zhu, W. Deng, Y. Xu, Y. Wang, L. Qiao, Y. Tan, L. Song, G. Wang, X. Du, N. Gao, J. Liu, J. Xiao, X. Su,Z. Du, Y. Feng, C. Qin*, C. Qin*, R. Jin*, X. S. Xie*, Potent Neutralizing Antibodies against SARS-CoV-2 Identified by High-Throughput Single-Cell Sequencing of Convalescent Patients’ B Cells. Cell. 182: 73-84.e16 (2020).
7. F. Jian#, A. Z. Wec#, L. Feng#, Y. Yu, L. Wang, P. Wang, L. Yu, J. Wang, J. Hou, D. M. Berrueta, D. Lee, T. Speidel, L. Ma, T. Kim, A. Yisimayi, W. Song, J. Wang, L. Liu, S. Yang, X. Niu, T. Xiao, R. An, Y. Wang, F. Shao, Y. Wang, S. Pecetta, X. Wang*, L. M. Walker*, Y. Cao*. Viral evolution prediction identifies broadly neutralizing antibodies to existing and prospective SARS-CoV-2 variants. Nature Microbiology.10: 2003-2017 (2025).
8.S. Yang#, Y. Yu#, Y. Xu, F. Jian, W. Song, A. Yisimayi, P. Wang, J. Wang, J. Liu, L. Yu, X. Niu, J. Wang, Y. Wang, F. Shao, R. Jin, Y. Wang, Y. Cao*, Fast evolution of SARS-CoV-2 BA.2.86 to JN.1 under heavy immune pressure. The Lancet Infectious Diseases. 24(2): e70-e72 (2024).
9.C. Yue, W. Song, L. Wang, F. Jian, X. Chen, F. Gao, Z. Shen, Y. Wang, X. Wang*, Y. Cao*, ACE2 binding and antibody evasion in enhanced transmissibility of XBB.1.5. The Lancet Infectious Diseases. 23(3):278-280 (2023).
10.Z. Cui#, P. Liu#, N. Wang#, L. Wang#, K. Fan#, Q. Zhu#, K. Wang#, R. Chen, R. Feng, Z. Jia, M. Yang, G. Xu, B. Zhu, W. Fu, T. Chu, L. Feng, Y. Wang, X. Pei, P. Yang, X. S. Xie, L. Cao*, Y. Cao*, X. Wang*, Structural and functional characterizations of infectivity and immune evasion of SARS-CoV-2 Omicron. Cell. 185(5): 860-871. (2022).
