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March 5th Frontiers in Biological Sciences Tsinghua University

Gregory J. Pazour, Ph.D.

Associate Professor, University of Massachusetts Medical School



1991   Ph.D. Biochemistry   University of Minnesota

1986   B.S. Chemistry, South Dakota State University

1986   B.S. Biology, South Dakota State University


Professional Experience:

2006-        Associate Professor of Molecular Medicine, University of Massachusetts Medical School

2002-2006    Assistant Professor of Molecular Medicine, University of Massachusetts Medical School

1999-2002    Research Assistant Professor of Cell Biology, University of Massachusetts Medical School

1997-1999    Instructor of Cell Biology, University of Massachusetts Medical Center

1991-1997    Postdoctoral Research Associate, Worcester Foundation for Biomedical Research


Topic: New Roles for an Ancient Organelle: Ciliary Defects Cause Cystic Kidney Disease and Structural Birth Defects


Dr. Pazour obtained his Ph.D at University of Minnesota and did his postdoctoral work at UMASSMedicalCenter, and is now an associate Professor at UMASS. The goal of his research is to understand the function of the primary cilium in mammalian development and also in tissue homeostasis and the development of disease.  A key finding of his postdoctoral work established that the Tg737 polycystic kidney disease gene encoded IFT88 and is required for ciliary assembly in both Chlamydomonas and mouse (Pazour et al. 2000 J Cell Biol).  This was the first demonstration of a ciliary defect in polycystic kidney disease and helped to usher in the modern era of primary cilia research.  Since becoming an independent investigator, his group has transitioned to mouse and mammalian cell culture to study cilia.  He has focused on understanding the processes by which ciliary membrane proteins are sorted and delivered to the ciliary membrane and the role that cilia play in the development of complex organs like the kidney, eye, heart and pancreas. Among the honors he has received include Bensley Award in Cell Biology from the American Association of Anatomists, Keith R. Porter Fellow, and Molecular Biology of the Cell Paper of the Year.


Venue: Room143, New Biology Building, THU

Time: Mar. 5 (Tuesday), 2013; 16:30

Host: Prof. Junmin Pan

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