INFECTIOUS DISEASES SEMINAR SERIES：ECM1 Controls Th2 Cell Egress from Lymph Nodes through Re-expression of S1P1
Speaker:Dr. Bing Sun,Professor
Shanghai Institute of Biochemistry and Cell Biology,
Shanghai Institutes for Biological Sciences,
Chinese Academy of Sciences
Time: 16:00, April 9 (Monday)
Place: Medical Science Building B321,Tsinghua University
Host: Hai Qi
Abstract: Th2 cells are differentiated from naïve CD4+ helper T cells, which have a crucial role in adaptive immune responses. They are critically involved in inflammatory diseases such as allergies and asthma. Migration of Th2 cells into inflammatory tissues requires sphingosine-1-phosphate (S1P) interaction with the S1P receptor S1P1. Although T cell trafficking is crucial for immunological responses, the mechanisms controlling specific migration patterns remain unclear. In the study, we demonstrated that extracellular matrix protein-1 (ECM1) is highly and selectively expressed in Th2 cells. ECM1 deficiency caused impaired Th2 responses and reduced allergic airway inflammation in vivo. Functional analysis demonstrated that although the Th2 polarization of ECM1-deficient cells was unimpaired, these cells had a defect in migration and were retained in peripheral lymphoid organs. This was associated with reduced expression of Krueppel-like factor 2 (KLF2) and S1P1. The scientists also found that ECM1 could directly bind the interleukin-2 (IL-2) receptor to inhibit IL-2 signaling and activate S1P1 expression. Their data have identified a previously unknown function of ECM1 in regulating Th2 cell migration through control of KLF2 and S1P1 expression. Thus, ECM1 could be a potential target in treating allergies and asthma.
Light Refreshments will be served!!!
Background:
The Centre for Infectious Diseases Research is holding a weekly seminar series. The seminars will be a great opportunity to hear speakers from both within and outside China speaking on a variety of subjects of interest to all those engaged in microbiology/immunology and allied disciplines. The coordinator of the seminar series is Babak Javid, and he would be delighted for fellow faculty to get in touch with regards to possible speakers to invite.
The seminars will also be of great interest to graduate students in life sciences, so we would appreciate PIs encouraging their students and post-docs to attend. By way of encouragement, we will be providing light refreshments to attendees.
If you are interested in meeting with the speaker, please email Babak Javid at bjavid@gmail.com.
We hope that this seminar series will prove to be a valuable addition for both training and scientific dialogue at Tsinghua, and look forward to seeing you there.
We hope that this seminar series will prove to be a valuable addition for both training and scientific dialogue at Tsinghua, and look forward to seeing you there.
