Minghui ZHAO
Email: mhzhao(at)bjmu(dot)edu(dot)cn；
Telephone: +86-10-83572550, 83572388；
Lab Homepage: http://www.renal-pku.org
Research Area:
Our research mainly focuses on severe autoimmune kidney diseases, including ANCA associated vasculitis, anti-GBM disease, lupus nephritis and thrombotic microangiopathy (TMA). The features of our research are to find scientific questions from routine clinical work, taking the advantage of our rich clinical disease resources, and using advanced immunological techniques to carry out mechanism research for eventual clinical application. The focuses of our research are epitope mapping of autoantibodies and the mechanisms of epitope spreading, etiologies of autoimmune kidney disease, and the role of abnormal complements activation in the development of kidney disease. The technologies used in our research involve molecular immunology, protein biochemistry, cell biology and molecular informatics.
Selected Publications:
1. Gou SJ, Yuan J, Chen M, Yu F, Zhao MH, Circulating complement activation profile of patients with ANCA-associated vasculitis. Kidney Int, In press, 2012.
2. Chen M, Gao Y, Guo XH, Zhao MH, Propylthiouracil-induced anti-neutrophil cytoplasmic antibody-associated vasculitis. Nat Rev Nephrol, 8(8): 476-83, 2012. (Review)
3. Cui Z, Zhao MH, Advances in human antiglomerular basement membrane disease. Nat Rev Nephrol, 7(12): 697-705, 2011. (Review)
4. Cui Z, Zhao MH, Segelmark M, Hellmark T, Natural autoantibodies to myeloperoxidase, proteinase 3 and the glomerular basement membrane are present in normal individuals. Kidney Int, 78(6): 590-7, 2010.
5. Yu F, Tan Y, Liu G, Wang XS, Zou WZ, Zhao MH, The clinicopathological characteristics and outcome of patients with crescentic lupus nephritis: A study from a single center. Kideny Int, 76: 307-317, 2009.
6. Zhao J, Cui Z*, Yang R, Jia XY, Zhang Y, Zhao MH, Anti-glomerular basement membrane autoantibodies against different target antigens are associated with disease severity. Kidney Int, 76(10): 1108-15, 2009.
7. Chen M, Kallenberg CGM, Zhao MH, Antineutrophil cytoplasmic autoantibodies-negative pauci-immune crescentic glomerulonephritis. Nat Rev Nephrol, 5(6): 313-318, 2009. (Review)
8. Yang R, Hellmark T, Zhao J, Cui Z, Segelmark M, Zhao MH, Wang HY, Antigen and epitope specificity of anti-glomerular basement membrane antibodies in patients with goodpasture disease with or without anti-neutrophil cytoplasmic antibodies. J Am Soc Nephrol, 18(4): 1338-43, 2007.
9. Chen M, Yu F, Wang SX, Zou WZ, Zhao MH, Wang HY, Antineutrophil cytoplasmic autoantibody negative pauci-immune crescentic glomerulonephritis. J Am Soc Nephrol, 18: 599-605, 2007.
10. Cui Z, Wang HY, Zhao MH. Natural autoantibodies against glomerular basement membrane exist in normal human sera. Kidney Int, 69:894-899, 2006.