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Email: wuli(at)tsinghua(dot)edu(dot)cn

Telephone:  +86-10-62794835


Research Area:

In Immune Cell Research Laboratory we are particularly interested in the fascinating immune cell type-the dendritic cells (DC). They are the most efficient antigen presenting cells. DC play important roles in either initiating antigen specific immune responses against pathogens or inducing immune tolerance to self-antigens. DC are heterogeneous and contain phenotypically and functionally distinct subpopulations. We are interested in how the development and functions of these DC populations are regulated by various molecules, including cytokines, transcription factors and miRNAs. We are also interested in revealing the possible association of abnormal DC development and functions and the development of some major diseases including infection, cancer and autoimmunity. Our research is mainly focused on: molecular regulation of immune cell lineage commitment and differentiation from multipotent heamatopoietic stem cells; development and functional diversities of mouse and human DC populations; the roles of DC in initiating specific immune responses against infectious agents and in the induction of immune tolerance.


Selected Publications:

1. AI Proietto, D Mittag, AW Roberts, N Sprigg and L Wu*. The equivalents of human blood and spleen dendritic cell subtypes can be generated in vitro from human CD34+ stem cells in the presence of fms-like tyrosine kinase 3 ligand and thrombopoietin. Cell & Mol. Immunol. 2012,9, 446–454. SCI. 

2. Yifan Zhan and Li Wu. Functional regulation of monocyte-derived dendritic cells by microRNAs.Protein & Cell. 2012, 3(7): 497–507. SCI.

3. Sathe P, Vremec D, Wu L, Corcoran L, Shortman K. Convergent differentiation: myeloid and lymphoid pathways to murine plasmacytoid dendritic cells. Blood. 2012. Oct 10. doi:10.1182/blood-2012-02-413336.

4. Carotta S, Dakic A, D’Amico A, Pang SHM, Greig KT, Nutt SL and Wu L. The Transcription Factor PU.1 Controls Dendritic Cell Development and Flt3 Cytokine Receptor Expression in a Dose Dependent Manner. Immunity 28:628-41, 2010

5. Proietto AI, van Dommelen S, Zhou P, Rizzitelli A, D'Amico A, Steptoe RJ, Naik SH, Lahoud MH, Liu Y, Zheng P, Shortman K and Wu L. Dendritic cells in the thymus contribute to T-regulatory cell induction. Proceedings of The National Academy of Sciences USA 105:19869-19874, 2008.

6. Naik SH, Sathe P, Park H-Y, Metcalf D, Anna I. Proietto AI, Dakic A, Carotta S, O’Keeffe M, Bahlo M, Papenfuss A, Kwak J-Y, Wu L and Shortman K. Development of plasmacytoid and conventional dendritic cell subtypes from single in vitro and in vivo-derived precursors. Nature Immunology 8:1217, 2007.

7. Wu L and Liu YJ. The Development of Dendritic Cell Lineages. Immunity. 26:741-750. 2007.

8. Shackleton M, Vaillant F, Simpson KJ, Stingl J, Smyth GK, Asselin-Labat ML, Wu L, Lindeman GJ, & Visvader JE. Generation of a functional mammary gland from a single stem cell. Nature 439:84-88. 2006.

9. Wu L, D’Amico A, Winkel K.D, Suter M, Lo D, Shortman K. RelB is essential for the development of Myeloid-related CD8a- dendritic cells but not of lymphoid-related CD8a+ dendritic cells. Immunity, 9:839-847, 1998.

10. Ardavin C, Wu L, Li C-L, Shortman K. Thymic dendritic cells and T cells develop simultaneously within the thymus from a common precursor population. Nature 362: 761-763, 1993.

11. Wu L, Scollay R, Egerton M, Pearse M, Spangrude GJ, Shortman K. CD4 expressed on earliest T-lineage precursor cells in the adult murine thymus. Nature 349: 71-74, 1991.


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