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Guo-Qiang CHEN



Guo-Qiang CHEN


E-mail: chengq(at)biomed(dot)tsinghua(dot)edu(dot)cn

Tel: +86-10-62783844


Research Area:

Biosynthesis and application of polymers, Metabolic engineering, Synthetic biology,fermentation engineering, Biomaterials.

Our lab focuses on the microbial production and applications of polyhydroxyalkanoates (PHA), a family of biodegradable and
biocompatible materials with good thermal and mechanical properties. Over the past 20+ years, we have contributed to the
development of a PHA industrial value chain ranging from microbial fermentation, environmentally friendly materials, medical
materials, biofuels, specialty materials, fine chemicals, foods and medicines. Large scale production of PHA has been achieved.
Currently China stays in an advanced position in PHA academic research and industrialization.


Selected Publications:

1. Cai L, Yuan MQ, Li ZJ, Chen JC and Chen GQ. Genetic engineering of Ketogulonigenium vulgare DSM 4025 to enhance the production of 2-keto-L-gulonic acid. J Biotechnol 157: 320– 325, 2012

2. Peng Q, Zhang ZR, Gong T, Chen GQ, Sun X. A rapid-acting, long-acting insulin formulation based on a phospholipid complex loaded PHBHHx nanoparticles. Biomaterials 33: 1583-1588, 2012

3. Dong CL, Li SY, Wang Y, Dong Y Tang ZGJ and Chen GQ. The cytocompatability of polyhydroxyalkanoates coated with a fusion protein of PHA repressor protein (PhaR) and Lys-Gln-Ala-Gly-Asp-Val (KQAGDV) polypeptide. Biomaterials 33: 2593-2599, 2012

4. Chen GQ and Patel M. Plastics Derived from Biological Sources: Present and Future - A Technical and an Environmental Review. Chemical Rev 112: 2082-2099, 2012

5. Tripathi L, Wu LP and Chen GQ. Microbial synthesis of diblock copolymer poly-3-hydroxybutyrate-block-poly-3-hydroxyhexanoate [P(3HB)-b-P(3HHx)] by a genome reduced Pseudomonas putida KT2442. Microbial Cell Factories 11:44, 2012

6. Meng DC, Shi ZY, Wu LP, Zhou Q, Wu Q, Chen JC and Chen GQ. Production and characterization of poly(3-hydroxypropionate-co-4-hydroxybutyrate) with fully controllable structures by recombinant Escherichia coli containing an engineered pathway. Metab Eng 14: 317-324, 2012

7. Zhou XY, Yuan XX, Shi ZY, Meng DC, Jiang WJ, Wu LP, Wu Q, Chen JC and Chen GQ. Hyperproduction of poly(4-hydroxybutyrate) from glucose by recombinant E. coli. Microbial Cell Factories 11:54, 2012

8. Wang RY, Shi ZY, Chen JC and Chen GQ. Cloning large gene clusters from E. coli using in vitro single-strand overlapping annealing. ACS Synthetic Biology 1: 291–295, 2012

9. Wang RY, Shi ZY, Chen JC, Wu Q and Chen GQ. Enhanced co-production of hydrogen and poly-(R)-3-hydroxybutyrate by recombinant PHB producing E. coli over-expressing hydrogenase 3 and acetyl-CoA synthetase. Metab Eng 14: 496–503, 2012

10. Chen GQ. New challenges and opportunities for industrial biotechnology. Microbial Cell Factories 11: 111, 2012

11. Gao X, Yuan XX, Shi ZY, Shen XW, Chen JC, Wu Q and Chen GQ. Production of copolyesters of 3-hydroxybutyrate and medium-chain-length 3-hydroxyalkanoates by E. coli containing an optimized PHA synthase gene. Microbial Cell Factories 11:130, 2012

12. Gao X, Chen JC, Wu Q and Chen GQ. Polyhydroxyalkanoates as a source of chemicals, polymers and biofuels. CURRENT OPINIONS ON BIOTECHNOLOGY doi:10.1016/j.copbio.2011.06.005

13.  Liu Q, Luo G, Zhou XR and Chen GQ. Biosynthesis of Poly(3-hydroxydecanoate) and 3-Hydroxydodecanoate Dominating Polyhydroxyalkanoates by -Oxidation Pathway Inhibited Pseudomonas putida. METABOLIC ENGINEERING 13(1): 11-17, 2011

14.  Peng SW, Guo XY, Shang GG, Li J, Xu XY, You ML, Li P, Chen GQ. An Assessment of the Risks of Carcinogenicity Associated with Polyhydroxyalkanoates through an Analysis of DNA Aneuploid and Telomerase Activity. BIOMATERIALS 32(10): 2546-2555, 2011

15.  Li ZJ, Shi ZY, Jian J, Guo YY, Wu Q and Chen GQ. Production of Poly(3-hydroxybutyrate-co-4-hydroxybutyrate) from Unrelated Carbon Sources by Metabolically Engineered Escherichia coli. METABOLIC ENGINEERING 12(4): 352-359, 2010

16.  Chen GQ. A Polyhydroxyalkanoates Based Bio- and Materials Industry. CHEMICAL SOCIETY REVIEWS 38 (8): 2434–2446, 2009

17.  Zhang XJ, Luo RC, Wang Z, Deng Y and Chen GQ. Applications of (R)-3-hydroxyalkanoate Methyl Esters Derived from Microbial Polyhydroxyalkanoates as Novel Biofuel. BIOMACROMOLECULES 10: 707–711, 2009

18.  Zou XH, Li HM, Wang S, Leski M, Yao YC, Yang XD, Huang QJ and Chen GQ. The Effect of 3-Hydroxybutyrate Methyl Ester on Learning and Memory in Mice. BIOMATERIALS 30: 1532-1541, 2009

19.  Chen GQ and Wu Q. Polyhydroxyalkanoates as Tissue Engineering Materials. BIOMATERIALS 26(33): 6565-6578, 2005


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