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Hai Qi


Hai Qi


E-mail: qihai(at)mail(dot)tsinghua(dot)edu(dot)cn

Research Area:

Operation of the immune system critically depends on highly dynamic intercellular communication among multiple cell types, frequently in the form of physical cell-cell interactions. Germinal centers (GCs) are highly organized tissue micro-domains in which multicellular interactions are dynamically orchestrated to produce humoral immune memory. We try to understand: (1) how cellular interactions critical for GC formation are molecularly orchestrated, (2) how qualitative and quantitative properties of such interactions are translated into cell fate decisions, (3) how lymphoid tissues and GC micro-domains are spatiotemporally patterned, and (4) how such patterns facilitate productive yet prevent unwanted immune activation. To approach these questions, we utilize genetic, biochemical, cell biological, live cell imaging, and intravital 2-photon tissue imaging methods. 


Selected Publications:

1.    Dan Liu*, Heping Xu*, Changming Shih, Zurong Wan, Xiaopeng Ma, Weiwei Ma, Dan Luo, and Hai Qi#. T-B cell entanglements and ICOSL-driven feed-forward regulation of germinal centre reaction.Nature, 2014 (Oct 15, Epub ahead of print, doi:10.1038/nature13803).

2.    Coco Chu, Yifeng Wang, Xu Zhang, Xinya Ni, Junxia Cao, Wan Xu, Zhongjun Dong, Pengfei Yuan, Wensheng Wei, Yuanwu Ma, Lianfeng Zhang, Longyan Wu, and Hai Qi#. SAP-regulated T cell-APC adhesion and ligation-dependent and -independent Ly108-CD3z interactions. Journal of Immunology, 193:3860-3871, 2014 (Sep 12, Epub ahead of print, doi:10.4049/jimmunol.1401660)

3.    Hai Qi#, Wolfgang Kastenmuller# and Ronald N Germain#. Spatio-temporal basis of innate and adaptive immunity in secondary lymphoid tissue. Annual Review of Cell and Developmental Biology, 2014 (Aug 8, Epub ahead of print, doi: 10.1146/annurev-cellbio-100913-013254)

4.    Hai Qi#, Dan Liu, Weiwei Ma, Yifeng Wang, Hu Yan. Bcl-6 controlled TFH polarization and memory: the known unknowns. Current Opinion in Immunology, 28:34-41, 2014

5.    Heping Xu, Xuanying Li, Dan Liu, Jianfu Li, Xu Zhang, Xin Chen, Shiyue Hou, Lixia Peng, Chenguang Xu, Wanli Liu, Lianfeng Zhang, and Hai Qi#. Follicular T-helper cell recruitment governed by bystander B cells and ICOS-driven motility. Nature 496:523-527, 2013.

6.    Hai Qi#. From SAP-less T cells to helpless B cells and back: dynamic T-B interactions in germinal center development. Immunological Reviews 247:24-35, 2012.

7.    Hai Qi*, Jennifer L. Cannons*, Frederick Klauschen, Pamela L. Schwartzberg, and Ronald N. Germain. SAP-controlled T-B cell interactions underlie germinal centre formation. Nature 455:764-769, 2008.

8.    Hai Qi, Jackson G. Egen, Alex Y. C. Huang, and Ronald N. Germain. Extrafollicular activation of lymph node B cells by antigen-bearing dendritic cells. Science 312:1672-1676, 2006.



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