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Email: xingchen(at)pku(dot)edu(dot)cn;

Telephone: +86-10-62752747;

Lab Homepage: www.chem.pku.edu.cn/xchengrp



Research Area:

Integrating chemistry and biology enables probing, understanding, and manipulating biological processes in ways not possible before. Our group focuses on developing chemical tools to elucidate the biological function of glycosylation, with an emphasis on in vivo labeling, visualization, and profiling of glycosylation dynamics. We are particularly interested in how glycosylation regulates the physiology and pathology in the brain. Much of our research takes a highly interdisciplinary approach to tackle important questions related to human health and disease.


Selected Publications:

1. Qin, W.; Lv, P.; Fan, X.; Quan, B.; Zhu, Y.; Qin, K.; Chen, Y.; Wang, C.; Chen, X. “Quantitative Time-Resolved Chemoproteomics Reveals Stable O-GlcNAc Regulates Box C/D snoRNP Biogenesis” Proc. Natl. Acad. Sci. USA 114, E6749-E6758 (2017).

2. Xie, R.; Dong, L.; Du, Y.; Zhu, Y.; Hua, R.; Zhang, C.; Chen, X. “In Vivo Metabolic Labeling of Sialoglycans in the Mouse Brain By Using A Liposome-Assisted Bioorthogonal Reporter Strategy” Proc. Natl. Acad. Sci. USA 113, 5173-5178 (2016).

3. Zhu, Y.; Wu, J.; Chen, X. “Metabolic Labeling and Imaging of N-Linked Glycans in Arabidopsis Thaliana” Angew. Chem. Int. Ed  55, 9301-9305 (2016).

4. Lin, L.; Liu, L.; Zhao, B.; Xie, R.; Lin, W.; Li, H.; Shi, M.; Chen, Y.; Springer, T. A.; Chen, X. “Carbon Nanotube-Assisted Optical Activation of TGF- Signaling by Near-Infrared Light” Nature Nanotech. 10, 465-471 (2015).

5. Xie, R.; Dong, L.; Huang, R.; Hong, S.; Lei, R.; Chen, X. “Targeted Imaging and Proteomic Analysis of Tumor-Associated Glycans in Living Animals” Angew. Chem. Int. Ed. 53, 14082-14086 (2014).

6. Hong, S.; Chen, T.; Zhu, Y.; Li, A.; Huang, Y.; Chen, X. “Live-Cell Stimulated Raman Scattering Imaging of Alkyne-Tagged Biomolecules” Angew. Chem. Int. Ed. 53, 5827-5831 (2014).

7. Lin, W.; Du, Y.; Zhu, Y.; Chen, X. “A Cis-Membrane FRET-Based Method for Protein-specific Imaging of Cell-Surface Glycans” J. Am. Chem. Soc. 136, 679-687 (2014).

8. Feng, L.; Hong, S.; Rong, J.; You, Q.; Dai, P.; Huang, R.; Tan, Y.; Hong, W.; Xie, C.; Zhao, J.; Chen, X. “Bifunctional Unnatural Sialic Acids for Dual Metabolic Labeling of Cell-Surface Sialylated Glycans” J. Am. Chem. Soc. 135, 9244-9247 (2013).

9. Lin, L.; Tian, X.; Hong, S.; Dai, P.; You, Q.; Wang, R.; Feng, L.; Xie, C.; Tian, Z.; Chen, X. “A Bioorthogonal Raman Reporter Strategy for SERS Detection of Glycans on Live Cells” Angew. Chem. Int. Ed. 52, 7266-7271 (2013).  

10. Xie, R.; Hong, S.; Feng, L.; Rong, J.; Chen, X. “Cell-Selective Metabolic Glycan Labeling Based on Ligand-Targeted Liposomes” J. Am. Chem. Soc. 134, 9914-9917 (2012).




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