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Luhua LAI


Luhua LAI


Email: lhlai(at)pku(dot)edu(dot)cn;

Telephone: +86-10-62757486;

Lab Homepage: http://mdl.ipc.pku.edu.cn/


Research Area: 

We focus on solving biological problems by using physical chemistry, computational, strucutral and biochemical methods. We are working on deciphering the basic rules governing protein sequence, structure and function relationship, mechanism of biomolecular interactions, protein design, structural based and systems based drug design by using combined approaches of modeling and experimental studies.  In order to do efficient protein, drug and systems design, we are developing novo computational methods and programs, and use them to study biomolecules and systems of interest.


Selected Publications:

1. Liu S, Liu SY, Zhu XL, Liang HH, Cao AN, Chang ZJ, Lai LH*, Nonnatural protein-protein interaction-pair design by key residues grafting, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 104 (13), 5330-5335, 2007.
2. Yang K, Ma WZ, Liang HH, Ouyang Q, Tang C, Lai LH*, Dynamic simulations on the arachidonic acid metabolic
network. PLOS COMPUTATIONAL BIOLOGY, 3(3), 523-530, 2007.
3. Yang K, Bai HJ, Ouyang Q, Lai LH*, Tang C, Finding multiple target optimal intervention in disease-related molecular
network. MOLECULAR SYSTEMS BIOLOGY, 4, 228.1-228.13, 2008.
4. Wei DG, Jiang XL, Zhou L, Chen J, Chen Z, He C, Yang K, Liu Y, Pei JF, Lai LH*, Discovery of Multitarget Inhibitors by
Combining Molecular Docking with Common Pharmacophore Matching. JOURNAL OF MEDICINAL CHEMISTRY, 51 (24), 7882-7888, 2008.
5. Liang HH, Chen H, Fan KQ, Wei P, Guo XR, Jin CW, Zeng C, Tang C, Lai LH*, De Novo Design of a beta alpha beta
Motif. ANGEWANDTE CHEMIE INTERNATIONAL EDITION, 48, (18), 3301-3303, 2009.




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