Yuxin YIN
Email: yinyuxin@hsc.pku.edu.cn
Telephone: +86-10-8280-5570 (office)
Lab Homepage: http://www.isb.pku.edu.cn
Research Area:
Professor Yuxin Yin’s research field is cancer genetics with main focus on the roles of tumor suppressors p53 and PTEN in cell cycle regulation, apoptosis and genomic stability. In 1992, he found a fundamental role of p53 in controlling the G1 checkpoint and maintaining genomic stability. In 1998, he reported that p53 is required for the cellular apoptotic response to oxidative stress. In 2003, his team at Columbia demonstrated that PAC1 phosphatase is a direct transcriptional target of p53 in signaling apoptosis and tumor suppression, establishing a link between p53 and the MAP kinase cascade. They also found that RAD9 is a transcription factor and that RAD9 can regulate p21 and other genes involved in cell cycle checkpoints and embryogenesis. In 2007, his group reported that PTEN plays a fundamental role in the maintenance of chromosome stability and that PTEN does so through physical interaction with centromeres. In 2010, Dr. Yin established a laboratory of Cancer Genetics in the Institute of Systems Biomedicine at Peking University Health Science Center. In recent years, his team has been investigating novel functions of nuclear PTEN in regulating the mitotic checkpoints. They also study the mechanism of the network of tumor suppressors. Their recent study reveals that the transcription factor CREB is a novel nuclear target of PTEN.
Selected Publications:
1. Yin, Y., Tainsky, M. A. Bischoff, F. A., Strong, L.C. and Wahl, G. M. (1992). Wild-type p53 restores cell cycle control and inhibits gene amplification in cells with mutant p53 alleles. Cell 70:937-948.
2. Yin, Y., Terauchi, Y., Solomon, G. G., Aizawa, S., Rangarajan, P. N., Yazaki, Y., Kadowaki, T, and Barrett, J. C. (1998). Involvement of p85 in p53-dependent apoptotic response to oxidative stress. Nature 391: 707-710.
3. Yin, Y.*, Liu, Y. X., Jin, Y. J., Hall, E. J., and Barrett, J. C. (2003). PAC1 phosphatase is a transcription target of p53 in signaling apoptosis and growth suppression. Nature 422:527-531.
4. Shen, W. H., Balajee, A. B., Wang, J., Wu, H., Eng, C., Pandolfi, P. P., and Yin, Y.* (2007). Essential role for nuclear PTEN in maintaining chromosomal integrity. Cell, 128: 157-170.
5. Liang, H., He, S., Yang, J., Jia, X., Wang, P., Chen, X., Zhang, Z., Zou, X., McNutt, M.A., Shen, W.H.,* and Yin, Y.*. (2014). PTENα is a PTEN isoform Translated through Alternative Initiation and Regulates Mitochondrial Function. Cell Metab. 19, 836-848.
6. Wang, G., Li, Y., Wang, P., Liang, H., Cui, M., Zhu, M., Guo, L., Su, Q., Sun, Y., McNutt, M.A., and Yin, Y.*. (2015). PTEN regulates RPA1 and protects DNA replication forks. Cell Res. 25, 1189-1204.
7. Lu, D., Liu, L., Ji, X., Gao, Y., Chen, X., Liu, Y., Liu, Y., Zhao, X., Li, Y., Li, Y., Jin, Y., Zhang, Y., McNutt, M.A., and Yin, Y.*(2015).The phosphatase DUSP2 controls the activity of the transcription activator STAT3 and regulates TH17 differentiation. Nat Immunol., 16, 1263-1273.
8. Lu, D., Liu L, Sun Y, Song J, Yin Q, Zhang G, Qi F, Hu Z, Yang Z, Zhou Z, Hu Y, Zhang L, Ji J, Zhao X, Jin Y, McNutt MA, Yin, Y.*(2020). The phosphatase PAC1 acts as a T cell suppressor and attenuates host antitumor immunity. Nat Immunol., 21, 287-297.
9. Wang, G., Qiu, M., Xing, X., Zhou, J., Yao, H., Li, M., Yin, R., Hou, Y., Li, Y., Pan, S., Huang, Y., Yang, F., Bai, F., Nie, H., Di, S., Guo, L., Meng, Z., Wang, J., Yin, Y*. (2022). Lung cancer scRNA-seq and lipidomics reveal aberrant lipid metabolism for early-stage diagnosis. Sci Transl Med., 14(630):eabk2756.
10. Zheng L, Liang H, Zhang Q, Shen Z, Sun Y, Zhao X, Gong J, Hou Z, Jiang K, Wang Q, Jin Y, Yin, Y*. (2022). circPTEN1, a circular RNA generated from PTEN, suppresses cancer progression through inhibition of TGF-β/Smad signaling. Mol Cancer. 21(1):41.
*Corresponding author