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Aibin He

 

Aibin He

 

Email: ahe(at)pku(dot)edu(dot)cn

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Lab Homepage: http://www.imm.pku.edu.cn/news.php?id=1740

 

Research Area:

Heart is the first functioning organ to form during embryogenesis. Embryonic heart undergoes rapid proliferation, while in normal adult heart the capacity of proliferation remains extremely lower. During heart development, distinct chromatin landscapes determine cardiac mesoderm specification, cardiac progenitor commitment, and cardiac lineage differentiation, as well as subsequent cardiomyocyte maturation. These same mechanisms govern cardiac progenitor expansion and differentiation in therapeutic regeneration. The long-term goal of my lab is to understand the epigenetic mechanisms that govern cardiogenesis and heart disease, and cardiomyocyte lineage conversion in vitro. We seek to understand the mechanisms of functional ventricular cardiomyocyte formation to enhance development of cells that can be used for therapeutic cardiac regenerative medicine. Identification of the critical regulators of cardiac progenitors and cardiomyocytes fates warrants understanding of interplay between the dynamic enhancomes and histone codes. Generally, we will approach them through the following perspectives: (1) Epigenetic mechanisms regulating cardiogenesis and heart disease. (2) Epigenetic regulation of adult cardiac progenitor cells renewal and differentiation. These goals address questions with both fundamental biological significance, and with direct relevance to our understanding of disease pathogenesis and avenues for myocardial regeneration.

 

Selected Publications:

1. Ai S, Yu X, Li Y, Peng Y, Li C, Yue Y, Tao G, Li CY, Pu WT, He A. Divergent Requirements for EZH1 in Heart Development Versus Regeneration. Circ Res. 2017 May 16. pii: CIRCRESAHA.117.311212. doi: 10.1161/CIRCRESAHA.117.311212. [Epub ahead of print].

2. Ai S, Peng Y, Li C, Gu F, Yu X, Yue Y, Ma Q, Chen J, Lin Z, Zhou P, Xie H, Prendiville TW, Zheng W, Liu Y, Orkin SH, Wang DZ, Yu J, Pu WT, He A. EED orchestration of heart maturation through interaction with HDACs is H3K27me3-independent. Elife. 2017;6.

3. Chen JY, Shen QS, Zhou WZ, Peng J, He BZ, Li Y, Liu CJ, Luan X, Ding W, Li S, Chen C, Tan BC, Zhang YE, He A#, Li CY#. Emergence, Retention and Selection: A Trilogy of Origination for Functional De Novo Proteins from Ancestral LncRNAs in Primates. PLoS Genet. 2015;11:e1005391. co-corresponding author

4. He A#, Gu F, Hu Y, Ma Q, Yi Ye L, Akiyama JA, Visel A, Pennacchio LA, Pu WT. Dynamic GATA4 enhancers shape the chromatin landscape central to heart development and disease. Nat Commun. 2014;5:4907. co-corresponding author

5. He A, Ma Q, Cao J, von Gise A, Zhou P, Xie H, Zhang B, Hsing M, Christodoulou DC, Cahan P, Daley GQ, Kong SW, Orkin SH, Seidman CE, Seidman JG, Pu WT. Polycomb Repressive Complex 2 Regulates Normal Development of the Mouse Heart. Circ Res. 2012;110:406-15.

6. He A#, Pu WT. Mature Cardiomyocytes Recall Their Progenitor Experience Via Polycomb Repressive Complex 2. Circ Res. 2012;111:162-4. co-corresponding author

7. He A, Shen X, Ma Q, Cao J, von Gise A, Zhou P, Wang G, Marquez VE, Orkin SH, Pu WT. PRC2 directly methylates GATA4 and represses its transcriptional activity. Genes Dev. 2012;26:37-42.

8. He A, Kong SW, Ma Q, Pu WT. Co-occupancy by multiple cardiac transcription factors identifies transcriptional enhancers active in heart. Proc Natl Acad Sci U S A. 2011;108:5632-7.

9. Wang G, McCain ML, Yang L, He A, Pasqualini FS, Agarwal A, Yuan H, Jiang D, Zhang D, Zangi L, Geva J, Roberts AE, Ma Q, Ding J, Chen J, Wang DZ, Li K, Wang J, Wanders RJ, Kulik W, Vaz FM, Laflamme MA, Murry CE, Chien KR, Kelley RI, Church GM, Parker KK, Pu WT. Modeling the mitochondrial cardiomyopathy of Barth syndrome with induced pluripotent stem cell and heart-on-chip technologies. Nat Med. 2014;20:616-23.

10. Yang Y, Liu B, Xu J, Wang J, Wu J, Shi C, Xu Y, Dong J, Wang C, Lai W, Zhu J, Xiong L, Zhu D, Li X, Yang W, Yamauchi T, Sugawara A, Li Z, Sun F, Li X, Li C, He A, Du Y, Wang T, Zhao C, Li H, Chi X, Zhang H, Liu Y, Li C, Duo S, Yin M, Shen H, Belmonte JC, Deng H. Derivation of Pluripotent Stem Cells with In Vivo Embryonic and Extraembryonic Potency. Cell. 2017;169:243-257.e25.

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