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Chu Wang


Chu Wang


Email: chuwang(at)pku(dot)edu(dot)cn

Telephone: +86-10-62758644(office); +86-10-62768657(Lab)

Office:College of Chemistry and Molecular Engineering, Room B241, Peking University, 100871

Lab Homepage:  www.chem.pku.edu.cn/wangchulab 


Research Area:

My research program will focus on the development and application of multi-disciplinary tools in chemoproteomics, biochemistry, bioinformatics and computational structure biology to 1) uncover novel amino acid sites in enzymes that are post-translationally regulated by endogenous reactive metabolites when cells are under oxidative stress or targeted by specific drug molecules 2) interrogate the underlying molecular mechanisms by which these modifications regulate protein function to perturb key signaling pathways in cells and 3) develop modeling tools to investigate protein-small molecule interactions, These studies have the great potential to provide penetrating mechanistic insights into the molecular basis for numerous diseases functionally linked to oxidative stress, including inflammation, cancer, and metabolic disorders, as well as to integrate and streamline efforts in inhibitor discovery, drug design and the functional annotation of uncharacterized enzymes in the post-genomic era.


Selected Publications:

1. Wang C#, Weerapana E, Blewett M, Cravatt BF#. (2014) A chemoproteomic platform to quantitatively map targets of lipid-derived electrophiles. Nature Methods 11:79-85 (# co-corresponding author)
2. Weerapana E*, Wang C*, Simon GM, Richter F, Khare S, Dillon MB, Bachovchin DA, Mowen K, Baker D, Cravatt BF. (2010). Quantitative reactivity profiling predicts functional cysteines in proteomes. Nature 468:790-5. (* co-first author)
3. Wang C, Vernon R, Lange O, Tyka M, Baker D. (2010) Prediction of structures of zinc-binding proteins through explicit modeling of metal coordination geometry. Protein Sci 19:494-506.
4. Wang, C., Bradley, P. & Baker, D. (2007). Protein-protein docking with backbone flexibility. J Mol Biol 373, 503-19.
5. Wang, C.*, Schueler-Furman, O.* & Baker, D. (2005). Improved side-chain modeling for protein-protein docking. Protein Sci 14, 1328-39. (* co-first author)


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