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Xu Tan

 

Xu Tan

Email: mosaictan@gmail.com

 

Research Area:

We are interested in developing high throughput methods for antiviral drug discovery targeting influenza virus, hepatitis B virus, dengue virus and HIV. A multitude of technologies including bioinformatics, live cell imaging, biochemistry and structural biology are used to study the mechanisms of actions of novel antiviral small molecules. We also study the mechanism of human antiviral innate immunity using functional genomics and mass spectrometry to help achieve a systems understanding of virus-host interactions. We always welcome highly motivated students to join us to work in the exciting area of translational medicine.

 

Selected Publications

1. Jiang C*, Mei M*, Li B*, Zhu X*, Zu W, Tian Y, Wang Q, Guo Y, Dong Y#Tan X#. A non-viral CRISPR/Cas9 delivery system for therapeutic gene targeting in vivo. Cell Research (2017) doi: 10.1038/cr.2017.16.

2. Lin Z*, Li S*, Feng C*, Yang S, Wang H, Ma D, Zhang J, Gou M, Bu D, Zhang T, Kong X, Wang X, Sarig O, Ren Y, Dai L, Liu H, Zhang J, Li F, Hu Y, Padalon-Brauch G, Vodo D, Zhou F, Chen T, Deng H, Sprecher E, Yang Y#Tan X#. Stabilizing mutations of KLHL24 ubiquitin ligase cause loss of keratin 14 and human skin fragility. Nature Genetics (2016) 48(12): 1508-1516

3. Tan X, Elledge SJ. When noise makes music: HIV reactivation with transcriptional noise enhancers. Genome Medicine (2014) 6(7): 55

4. Tan X, Hu L, Luquette LJ III, Gao G, Liu Y, Qu H, Xi R, Park PJ, Elledge SJ. Systematic Identification of Synergistic Drug Pairs Targeting HIV. Nature Biotechnology (2012) 30(11): 1125-1130

5. Tan X, Lu ZJ, Gao G, Xu Q, Hu L, Fellmann C, Li MZ, Qu H, Lowe SW, Hannon GJ, Elledge SJ. Tiling genomes of pathogenic viruses identifies potent antiviral shRNAs and reveals a role for secondary structure in shRNA efficacy. Proc Natl Acad Sci U S A. (2012) 109 (3): 869-874

6. Calderón Villalobos LI, Lee S, De Oliveira C, Ivetac A, Brandt W, Armitage L, Sheard LB, Tan X, Parry G, Mao H, Zheng N, Napier R, Kepinski S, Estelle M. A combinatorial TIR1/AFB-Aux/IAA co-receptor system for differential sensing of auxin. Nature Chemical Biology (2012) 8(5): 477-485

7. Sheard LB*, Tan X*, Mao H*, Withers J, Ben-Nissan G, Hinds TR, Kobayashi Y, Hsu FF, Sharon M, Browse J, He SY, Rizo J, Howe GA, Zheng N, Jasmonate perception by inositol-phosphate-potentiated COI1-JAZ co-receptor. Nature(2010) 468(7322): 400-405

8. Chou DM, Adamson B, Dephoure NE, Tan X, Nottke AC, Hurov KE, Gygi SP, Colaiácovo MP, Elledge SJ, A chromatin localization screen reveals poly (ADP ribose)-regulated recruitment of the repressive polycomb and NuRD complexes to sites of DNA damage. Proc Natl Acad Sci USA. (2010) 107(43): 18475-18480

9. Tan X, Calderon-Villalobos LIA, Sharon M, Zheng C, Robinson CV, Estelle M & Zheng N, Mechanism of Auxin Perception by the TIR1 ubiquitin ligase. Nature (2007) 446(7136): 640-645 (Cover Article)

10. Tan X & Zheng N, Hormone Signaling Through Protein Destruction - A Lesson From Plants. American Journal of Physiology – Endocrinology & Metabolism (2009) 296:223-227 (Review)

11. Hayashi K, Tan X, Zheng N, Hatate T, Kimura Y, Kepinski S, Nozaki H, Small molecule agonists and antagonists of F-box protein-substrate interactions in auxin perception. Proc Natl Acad Sci U S A. (2008) 105(14): 5632-5637

 (*: co-first authors, #: co-corresponding authors)

 

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