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Xueming Li


Xueming Li

Email: lixueming@mail.tsinghua.edu.cn 


Homepage: em.life.tsinghua.edu.cn


Main Research Fields:

We focus on the theoretical and methodological development of electron cryo-microscopy(CryoEM) and its application in structural biology to address important biological questions. We are particularly interested in developing and applying novel image processing technology to advance CryoEM for routine atomic-resolution structure analysis of biological macromolecules.


Selected Publications:

 ●  Soyeon Park*, Xueming Li*, Homin Kim*, Chingakham Ranjit Singh, Geng Tian, Martin A. Hoyt, Scott Lovell, Kevin P. Battaile, Michal Zolkiewski, Philip Coffino, Jeroen Roelofs, Yifan Cheng, and Daniel Finley, Reconfiguration of the proteasome during chaperone-mediated assembly, Nature497, 512-516, 2013. (*co-first author)

●   Xueming Li, Paul Mooney, Shawn Zheng, Chris Booth, Michael B. Braunfeld, Sander Gubbens, David A. Agard and Yifan Cheng, Electron counting and beam-induced motion correction enable near atomic resolution single particle cryoEM, Nature Methods10, 584-590, 2013.

¶ Featured in Nature Methods News and Views: Robert M. Glaeser (2013) Stroboscopic imaging of macromolecular complexes. Nature Methods 10, 475-476.

¶ Featured in Nature MethodsMethod of the Year 2013.

 ●   Xueming Li, Shawn Zheng, Kiyoshi Egami,David A. Agard, Yifan Cheng, Influence of electron dose rate on electron counting images recorded with the K2 camera, J Struct. Biol.184, 251-260, 2013.

 ●   Patricia Grob, Derek Bean, Dieter Typke, Xueming Li, Eva Nogales, and Robert M. Glaeser, Ranking TEM cameras by their response to electron shot noise, Ultramicroscopy, 1331-7, 2013

 ●   Shenping Wu, Agustin Avila-Sakar, JungMin Kim, David S. Booth, Charles H. Greenberg, Andrea Rossi, Maofu Liao, Xueming Li, Akram Alian, Sarah L. Griner, Narinobu Juge, Yadong Yu, Claudia M. Mergel, Javier Chaparro-Riggers, Pavel Strop, Robert Tampé, Robert H. Edwards, Robert M. Stroud, Charles S. Craik, Yifan Cheng, Fabs enable single particle cryoEM studies of small proteins, Structure20, 582-592, 2012.

 ●   Agustin Avila-Sakar, Xueming Li, Shawn Q. Zheng, and Yifan. Cheng, Recording high-resolution images of two-dimensional crystals of membrane proteins, Chapter 8, Electron crystallography of soluble and membrane proteins, Methods in Molecular Biology, 955, 129- 152, 2012.

 ●   Xueming Li, Nikolaus Grigorieff, Yifan. Cheng, GPU-enabled FREALIGN: accelerating single particle 3D reconstruction and refinement in Fourier space on graphics processors, J Struct Biol.172, 407-12, 2010



In Physics and material science

  Xueming Li, Fanghua Li, Huiqian Luo, Lei Fang, Hai-hu Wen, Transmission electron microscopy study of one-dimensional incommensurate structural modulation in superconducting oxides Bi2+xSr2-xCuO6+δ (0.1≤x≤0.4), Superconductor Science and Technology22, 065003, 2009

  Xueming Li, Fanghua Li, Haifu Fan, A revised version of the program VEC, Chinese Physics B18(6), 2459-2463, 2009

  Binghui Ge, Yumei Wang, Xueming Li, Fanghua Li , H.L. Song, H.J. Zhang, A study of an incommensurately modulated structure in Ca0.28Ba0.72Nb2O6 by electron microscopy, Philosophical Magazine Letters88, 213 – 217, 2008

  Binghui Ge, Fanghua Li, Xueming Li, Yumei Wang, Zhenhua Chi, Changqing Jin, Study of superstructure II in multiferroic BiMnO3, Chinese Physics B17, 3163-3169, 2008

  Xueming Li, Si-ze Yang, Xingfang Wu, Preparation of Silicon Carbide Nitride Films on Si Substrate by Pulsed High-Energy Density Plasma, Journal of University of Science and Technology Beijing13(3), 272-276, 200613(3), 272-276, 2006


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