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Yun-Cai Liu

Yun-Cai Liu 




Research Area 

1.     The ubiquitin system in immune regulation

2.     Molecular basis of immune regulation and tolerance induction

3.     Establishment and mechanistic investigation of mouse models of autoimmune diseases, allergy, virus and bacterium infections.


Selected publications:

1.     Xiao, N., D. Eto, C. Elly, G. Peng, S. Crotty, and Y.C. Liu. The E3 ligase Itch is required for the differentiation of T follicular helper cells. Nat Immunol. 15:657-666. 2014

2.     Jin, H.S., Park, Y., Elly, C. & Liu, Y.C. Itch expression by Treg cells controls Th2 inflammatory responses. J Clin Invest. 123:4923-4934. 2013

3.     Huang, H., M.S. Jeon, L. Liao, C. Yang, C. Elly, J.R. Yates 3rd, and Y.C. Liu.  K33-linked polyubiquitination of T cell receptor-zeta regulates proteolysis-independent T cell signaling. Immunity 33:60-70. 2010

4.     Fang, D., C. Elly, B. Gao, N. Fang, Y. Altman, C. Joazeiro, T. Hunter, N. Copeland, N. Jenkins, and Y.C. Liu. Dysregulation of T lymphocyte function in itchy mice: a role for Itch in TH2 differentiation. Nat Immunol 3:281-287. 2002

5.     Joazeiro, C.A., S.S. Wing, H. Huang, J.D. Leverson, T. Hunter, and Y.C. Liu. The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase. Science 286:309-312. 1999
















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