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Jing Yang


Jing Yang


Email:   jing.yang (at)pku(dot)edu(dot)cn;

Research interest:Mechanism of neurodegenerative disorders


Research Area:

Our research is focused on the molecular pathways underlying the death of neurons or their axons in many neurodegenerative disorders. Our recent findings have begun to elucidate the signaling events that are central to the degeneration of axons under a variety of disease conditions. Interestingly, neurodegenerative insults often trigger a death program that is independent of the classic apoptosis pathway as well as the necroptosis pathway. Taking the combinatorial approach of neurobiology, biochemistry and metabolism, our ongoing research is aimed to address some of the most important questions in the field: (1) How do neurons or their axons respond to the damages inflicted by neurodegenerative insults? (2) How do the changes of metabolic status within damaged neurons or their axons determine the degeneration process? (3) How do the non-neuronal cells (e.g., glial cells) function in neurodegeneration? Our in-depth understanding of the pathological mechanism of neurodegenerative disorders will facilitate the development of effective therapies to delay, reverse, and eventually cure, those debilitating diseases.


Selected Publications:

1. Yang J, Wu Z, Renier N, Simon DJ, Uryu K, Park DS, Greer PA, Tournier C, Davis RJ, and Tessier-Lavigne M., Pathological axonal death through a MAPK cascade that triggers a local energy deficit. Cell. 2015 Jan 15;160(1-2):161-76.
2. Renier N, Wu Z, Simon DJ, Yang J, Ariel P, and Tessier-Lavigne M., iDISCO: a simple, rapid method to immunolabel large tissue samples for volume imaging. Cell. 2014 Nov 6;159(4):896-910.
3. Yang J, Weimer RM, Kallop D, Olsen O, Wu Z, Renier N, Uryu K, and Tessier-Lavigne M., Regulation of axon degeneration after injury and in development by the endogenous calpain inhibitor calpastatin. Neuron. 2013 Dec 4;80(5):1175-89.
4. Osterloh JM, Yang J, Rooney TM, Fox AN, Adalbert R, Powell EH, Sheehan AE, Avery MA, Hackett R, Logan MA, MacDonald JM, Ziegenfuss JS, Milde S, Hou YJ, Nathan C, Ding A, Brown RH Jr, Conforti L, Coleman M, Tessier-Lavigne M, Züchner S, and Freeman MR., dSarm/Sarm1 is required for activation of an injury-induced axon death pathway. Science. 2012 Jul 27;337(6093):481-4.
5. Yang J, Brown MS, Liang G, Grishin NV, and Goldstein JL., Identification of the acyltransferase that octanoylates ghrelin, an appetite-stimulating peptide hormone. Cell. 2008 Feb 8;132(3):387-96.

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