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Peng Zou


Peng Zou


Email:   zoupeng (at)pku(dot)edu(dot)cn;

Research interest:Chemical Biology

Lab Homage:http://www.chem.pku.edu.cn/zou/


Research Area:

Our research focuses on the development and application of chemistry-enabled tools to study neuroscience. We strive to understand how neuronal functions arise through the complex interactions between physical forces, ionic fluxes, and biological macromolecules. To achieve this goal, we invent new methods to probe the underlying molecules in the context of living cells. Examples are fluorescent sensors, engineered enzymes, custom-built microscopes and software, etc. Our methods are drawing from a wide range of techniques, including protein engineering, molecular biology, chemical synthesis, fluorescence microscopy and quantitative modeling. Research projects include: Optical mapping of neuronal action potential waveforms. Proteomic mapping of protein-RNA interactions in the process of learning and memory. Novel probes for recording circuit-level activities.


Selected Publications:

1. V. Hung, P. Zou, H. Rhee, N. D. Udeshi, V. Cracan, T. Svinkina, S. A. Carr, V. K. Mootha, and A. Y. Ting. (2014). Proteomic mapping of the human mitochondrial intermembrane space in live cells via ratiometric APEX tagging. Mol. Cell, 55, 332-341.
2. P. Zou†, Y. Zhao†, A. D. Douglass, D. R. Hochbaum, D. Brinks, C. A. Werley, D. J. Harrison, R. E. Campbell, and A. E. Cohen. (2014). Bright and fast multicoloured voltage reporters via electrochromic FRET. Nat. Commun., 5, 4625. († equal contribution)
3. H. W. Rhee†, P. Zou†, N. D. Udeshi, J. D. Martell, V. K. Mootha, S. A. Carr, and A. Y. Ting. (2013). Proteomic mapping of mitochondria in living cells via spatially restricted enzymatic tagging. Science, 339, 1328-1331. († equal contribution)
4. J. D. Cohen, P. Zou, and A. Y. Ting. (2012). Site‐Specific protein modification using lipoic acid ligase and Bis-Aryl hydrazone formation. Chembiochem, 13, 888-894. 
5. P. Zou, and A. Y. Ting. (2011). Imaging LDL receptor oligomerization during endocytosis using a co-internalization assay. ACS Chem. Biol., 6, 308-313. 

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