Yifu Qiu
E-mail: yifu.qiu(at)pku(dot)edu(dot)cn
Telephone: +86-10-62761052
Research Area:
Our research goal is to understand the biology of metabolic stress and to develop novel therapeutic strategies against obesity and metabolic syndrome. By taking a combination of molecular, genetic, genomic, metabolic and immunological approaches, our laboratory studies 1) immune orchestration of energy homeostasis; 2) development and function of brown and beige fat; and 3) adipose tissue remodeling. Dr. Qiu has published his work in prestigious journals like Cell, Nature, Nature Immunology, Cell Metabolism and Nature Communications.
Selected Publications:
1. Shen H, Huang X, Zhao Y, Wu D, Xue K, Yao J, Wang Y, Tang N, Qiu Y*. (2022) The Hippo pathway links adipocyte plasticity to adipose tissue fibrosis. Nature Communications (Accepted).
2. Xue K, Wu D, Wang Y, Zhao Y, Shen H, Yao J, Huang X, Li X, Zhou Z, Wang Z, Qiu Y*. (2022) The mitochondrial calcium uniporter engages UCP1 to form a thermoporter that promotes thermogenesis. Cell Metabolism (Published online Aug. 16, 2022).
3. Yao J, Wu D, Zhang C, Yan T, Zhao Y, Shen H, Xue K, Huang X, Wang Z, Qiu Y*. (2021) Macrophage IRX3 promotes diet-induced obesity and metabolic inflammation. Nature Immunology, 22, 1268-1279.
4. Qiu Y, Nguyen KD, Odegaard JI, Cui X, Tian X, Locksley RM, Palmiter RD, Chawla A. (2014) Eosinophils and Type 2 Cytokine Signaling in Macrophages Orchestrate Development of Functional Beige Fat. Cell, 157, 1292–1308.
5. Nguyen KD#, Qiu Y#, Cui X, Goh YP, Mwangi J, David T, Mukundan L, Brombacher F, Locksley RM, Chawla A. (2011) Alternatively activated macrophages produce catecholamines to sustain adaptive thermogenesis. Nature, 480, 104-108. (#equal contribution).
6. Qiu Y, Mao T, Zhang Y, Shao M, You J, Ding Q, Chen Y, Wu D, Xie D, Lin X, Gao X, Kaufman RJ, Li W, Liu Y. (2010) A crucial role for RACK1 in regulation of glucose-stimulated IRE1alpha activation in pancreatic beta-cells. Science Signaling, 3, ra7.
7. Lee MW, Odegaard JI, Mukundan L, Qiu Y, Molofsky AB, Nussbaum JC, Yun K, Locksley RM, Chawla A. (2015) Activated Type 2 Innate Lymphoid Cells Regulate Beige Fat Biogenesis. Cell, 160, 74–87.
8. Nguyen KD, Fentress SJ, Qiu Y, Yun K, Cox JS, Chawla A. Circadian gene Bmal1 regulates diurnal oscillations to Ly6Chi inflammatory monocytes. (2013) Science, 341, 1483-1488. (Research article).