Gong Cheng
Email：gongcheng@mail.tsinghua.edu.cn
Tel：+86-10-62788494 (Office)
Research Statement：
Dr. Cheng leads a research unit studying the pathogenesis and immune responses of flaviviral infections in both hosts and vectors. Dengue, Zika and Japanese encephalitis viruses are areas of particular interest. Studies are directed at understanding the molecular basis of viral infection, virulence and transmission by animal models and patient populations.
Selected Publications：
1. Liu Y, Liu JY, Du SY, Shan C, Nie KX, Zhang RD, Li XF, Zhang RL, Wang T, Qin CF, Wang PH, Shi PY #, Cheng G #. Evolutionary enhancement of Zika virus infectivity in Aedes aegypti mosquitoes. Nature. 545: 482-486 (# Corresponding Author)
2. Xiao XP, Yang LJ, Pang XJ, Zhang RD, Zhu YB, Wang PH, Gao GJ #, Cheng G #. (2017) A Mesh-Duox pathway regulates homeostasis in the insect gut. Nature Microbiology. 1: 17020 (# Corresponding Author)
3. Liu Y, Liu JY, Cheng G #. (2016) Vaccines and immunization strategies for dengue prevention. Emerging Microbes & Infections. 5: e77 (# Corresponsding Author)
4. Liu JY, Liu Y, Nie KX, Du SY, Qiu JJ, Pang XJ, Wang PH, Cheng G #. (2016) Flavivirus NS1 protein in infected host sera enhances viral acquisition by mosquitoes. Nature Microbiology. 1: 16087 (# Corresponsding Author)
5. Pang XJ, Xiao XP, Liu Y, Zhang RD, Liu JY, Liu QY, Wang PH, Cheng G #. (2016) Mosquito C-type lectins maintain gut microbiome homeostasis. Nature Microbiology. 1: 16023 (# Corresponsding Author)
6. Cheng G #, Liu Y, Wang PH, Xiao XP. (2016) Mosquito defense strategies against viral infection. Trends in Parasitology. 32: 177–186 (# Corresponsding Author)
7. Xiao XP, Zhang RD, Pang XJ, Liang GD, Wang PH, Cheng G #. (2015) A neuron-specific antiviral mechanism prevents lethal flaviviral infection of mosquitoes. PLoS Pathogens. 11: e1004848 (# Corresponsding Author)
8. Xiao XP, Liu Y, Zhang XY, Wang J, Li ZF, Pang XJ, Wang PH, Cheng G #. (2014) Complement-related proteins control Flavivirus infection of Aedes aegypti by inducing antimicrobial peptides. PLoS Pathogens. 10: e1004027 (# Corresponsding Author)
9. Liu Y, Zhang FC, Liu JY, Xiao XP, Zhang SY, Qin CF, Xiang Y, Wang P, Cheng G #. (2014) Transmission-blocking antibodies against mosquito C-type lectins for Dengue prevention. PLoS Pathogens. 10: e1003931 (# Corresponsding Author)
10. Cheng G, Cox J, Wang PH, Krishnan MN, Dai JF, Qian F, Anderson JF, Fikrig E. (2010) A C-Type Lectin collaborates with a CD45 phosphatase homolog to facilitate West Nile Virus infection of mosquitoes. Cell. 142, 714-725.