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Lab Homepage: http://www.songgroup.org/


Research Area:

With the development of computational power and theoretical methods, computer simulations are playing more and more important roles in biological studies. We aim at revealing the function mechanisms of membrane proteins by using and developing multi-scale computer simulations, in collaboration with experimental studies. Our main interests currently involve permeation mechanism of ion channels, signaling through membrane-associated proteins, and interaction between antimicrobial peptides and lipid bilayers. In the mean time, we also try to contribute to membrane protein- or membrane-targeted drug design or optimization, and thereby to improve peoples health at large.


Selected Publications:

1. Kutzner, C., Köpfer, D., Machtens, J.-P., de Groot, B. L., Song, C., & Zachariae, U. (2016). Insights into the function of ion channels by computational electrophysiology simulations. Biochimica et Biophysica Acta (BBA) - Biomembranes, 1858, 1741–1752. 
2. Köpfer, D., Song, C., Gruene, T., Sheldrick, G. M., Zachariae, U., & de Groot, B. L. (2014). Ion permeation in K+ channels occurs by direct Coulomb knock-on. Science, 346, 352–355(CS as co-first and co-corresponding author).
3. Song, C., Weichbrodt, C., Salnikov, E. S., Dynowski, M., Forsberg, B. O., Bechinger, B., … Zeth, K. (2013). Crystal structure and functional mechanism of a human antimicrobial membrane channel. Proceedings of the National Academy of Sciences of the United States of America, 110, 4586–4591.
4. Song, C., & Corry, B. (2011). Testing the applicability of Nernst-Planck theory in ion channels: comparisons with Brownian dynamics simulations. PLoS One, 6, e21204.
5. Song, C., & Corry, B. (2010). Ion Conduction in Ligand-Gated Ion Channels: Brownian Dynamics Studies of Four Recent Crystal Structures. Biophys. J., 98, 404–411.
6. Song, C., & Corry, B. (2009). An intrinsic ion selectivity of narrow hydrophobic pores. J. Phys. Chem. B, 113, 7642–7649.

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