Zhibo LIU
Email: zbliu(at)pku(dot)edu(dot)cn；
Phone (Office ): +86-010-62759191
Research: Radiochemistry • Positron Emission Tomography
Lab Homepage: www.chem.pku.edu.cn/zliu
Research Area:
Research in the Liu group focuses on the development of novel radioactive molecules for Positron Emission Tomography (PET). We seek to discover molecular structure and activity that can contribute to interdisciplinary solutions for long-standing challenges in clinics. Our lab works on synthetic organic/bioconjugate chemistry, late-stage radiolabeling, PET imaging and mechanistic studies to persure the molecules of interest in early diagnosis, patient selection and tailored treatment.
Keywords: Radiochemistry, Chemical Biology, Positron Emission Tomography, Theranostics, Bench-to-Bedside Translation
Selected Publications:
1. Zhibo Liu*, Xiaoyuan Chen* Simple Bioconjugate Chemistry Serves Great Clinical Advances: Albumin as A Versatile Platform for Diagnosis and Precision Therapy. Chem. Soc. Rev., 2016, 45, 1432-1456 (*corresponding author)
2. Zhibo Liu*, Haojun Chen, Kai Chen, Yihan Shao, Dale O. Kiesewetter, Gang Niu, Xiaoyuan Chen* Boramino Acid as A Marker for Amino Acid Transporter. Science Advances, 2015;1:e1500694 (*corresponding author, highlighted on C&EN News)
3. Zhibo Liu*, Kuo-Shyan Lin, François Bénard, Dale O. Kiesewetter, David M. Perrin*, Xiaoyuan Chen* A Broadly Applicable One-step 18F-Labeling Protocol with Organotrifluoroborates. Nat. Protoc, 2015, 10, 1423–1432 (*corresponding author)
Zhibo Liu, Daniel Chao, Ying Li, Richard Ting, Jihyoon Oh, David M. Perrin From Minutes to Years: Predicting Solvolysis Rates for Organotrifluoroborates, Chem. Eur. J., 2015, 21, 3924-3928
4. Zhibo Liu, Maral Pourghiasian, Gemma Dias, Joseph Lau, Francois Benard, Kuo-shyan Lin, David M. Perrin, An Organotrifluoroborate for Broadly Applicable One-Step 18F-Labeling, Angew. Chem. Int. Ed., 2014, 53, 11876–11880 (Cover feature, highlighted on C&EN News)
5. Zhibo Liu, Mark Alex Radtke, May Q. Wong, Kuo-Shyan Lin, Donald Yapp, David M. Perrin, Dual Mode Fluorescent PET Tracers: Efficient modular synthesis of Rhodamine-[cRGD]2-Alkyl-18F-Trifluoroborate, Rapid 18F-labeling at very high specific activity, In vivo PET Imaging, and Ex vivo fluorescence, Bioconjugate Chem. 2014, 25, 1951–1962 (Cover feature)
6. Zhibo Liu, Maral Pourghiasian, Francois Benard, Jinhe Pan, Kuo-Shyan Lin, David M. Perrin, Preclinical Evaluation of A High Affinity 18F-Trifluorborate Octreotide Derivative for Somatostatin Receptor Imaging, J Nucl Med., 2014, 55, 1499-1505 (JNM Editor’s Choice Award)
7. Zhibo Liu, Ying Li, Jerome Lozada, Paul Schaffer, Michael J. Adam, Thomas J. Ruth, David M. Perrin, Stoichiometric Leverage: Rapid 18F-Aryltrifluoroborate Radiosynthesis at Exceptionally High Specific Activity For Click Conjugation, Angew. Chem. Int. Ed., 2013, 52, 2303-2307.
8. Zhibo Liu, Ying Li, Jerome Lozada, May Q. Wong, Jennifer Greene, Kuo-Shyan Lin, Donald Yapp, David M. Perrin, Kit-like 18F-labeling of RGD-19F-Arytrifluroborate in High Yield and at Extraordinarily High Specific Activity with Preliminary In Vivo Tumor Imaging, Nucl Med Biol, 2013, 40, 841-849.