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Yang Zhao

 

Yang Zhao

 Institute of Molecular Medicine, College of Future Technology, Center for Life sciences, Peking University

Email:yangzhao@pku.edu.cn

 

Research Area:

Yang Zhao graduated with a bachelor's degree from the School of Life Sciences at Peking University in 2003 and obtained a Ph.D. from Peking University in 2009. Since 2016, he has been the principle investigator of the "Cell Reprogramming and Regenerative Medicine Research Laboratory" at the Institute of Molecular Medicine in the College of Future Technology at Peking University. He serves as a doctoral supervisor and are a researcher at the Peking University Tsinghua University Joint Center for Life Sciences and the National Key Laboratory of Natural Medicines and Biomimetic Drugs. Yang has been selected as an outstanding young talent in the national "Ten Thousand Talents Program" and received support as an outstanding young researcher from the National Natural Science Foundation of China. He has also served as a leader for projects under the National Key Research and Development Program. Zhao Yang has made several breakthroughs in the fields of induced pluripotent stem cells and cell reprogramming, with over 20 papers published in journals such as Science, Cell, Circulation, Cell Stem Cell and Cell Discovery. The total number of citations for these achievements exceeds 4,000, and they have been recognized in various awards, including the "Top 10 Advances in Chinese Science in 2013" and the "Top 10 Technological Advances in Chinese Universities in 2013." Research directions for Dr. Zhao Yang include novel regenerative medical technologies based on the principles of cell reprogramming. Specific areas of focus include: 1. The molecular basis of cell plasticity and its applications in regenerative medicine; 2. Inducing in situ regeneration of myocardial cells using the principle of direct lineage reprogramming (transdifferentiation); 3. Cell fate regulation and reprogramming in tissue fibrosis and repair.

 

Selected Publications:

#Co-first author  *Correspondence

1.      Lin P, Bai Y, Nian X, Chi J, Chen T, Zhang J, Zhang W, Zhou B, Liu Y, Zhao Y*. Chemically induced revitalization of damaged hepatocytes for regenerative liver repair. iScience. 2023 Nov 22; 26(12):108532. doi: https://doi.org/10.1016/j.isci.2023.108532.  

2.      Tao Y, Yang Y, Yang Z, Wang L, Wang SQ, Zhao Y*. Robust small molecule-aided cardiac reprogramming systems selective to cardiac fibroblasts. iScience. 2023 Nov 14;26(12):108466. doi: 10.1016/j.isci.2023.108466.

3.      Wu J, Zhao H, Tao Y, Yang C, Yang Y, Zhou B*, Zhao Y*. An improved factor combination for in vivo reprogramming of cardiac myofibroblast to cardiomyocyte-like cell with dual recombinase tracing. Circulation. 2023 Nov 21;148(21):1728-1731. doi: 10.1161/CIRCULATIONAHA.122.062810.

4.      Yang X#, Chen D#, Sun Q#, Wang Y, Xia Y, Yang J, Lin C, Dang X, Cen Z, Liang D, Wei R, Xu Z, Xi G, Xue G, Ye C, Wang LP, Zou P, Wang SQ, Rivera-Fuentes P, Püntener S, Chen Z, Liu Y*, Zhang J*, Zhao Y*. A live-cell image-based machine learning strategy for reducing variability in PSC differentiation systems. Cell Discovery. 2023 Jun 6;9(1):53. doi: 10.1038/s41421-023-00543-1.

5.      Li J#, Bai Y#, Liu Y, Song Z, Yang Y, Zhao Y*. Transcriptome-based chemical screens identify CDK8 as a common barrier in multiple cell reprogramming systems. Cell Reports. 2023 May 24;42(6):112566. doi: 10.1016/j.celrep.2023.112566.

6.      Li J, Chi J, Yang Y, Song Z, Yang Y, Zhou X, Liu Y*, Zhao Y*. PHDs-seq: a large-scale phenotypic screening method for drug discovery through parallel multi-readout quantification. Cell Regeneration. 2023 Jun 2;12(1):22. doi: 10.1186/s13619-023-00164-9.

7.      Bai Y, Yang Z , Xu X , Ding W , Qi J , Liu F , Wang X , Zhou B , Zhang W , Zhuang X,  Li G , Zhao Y*  Direct chemical induction of hepatocyte-like cells with capacity for liver repopulation. Hepatology. 2023 May 1;77(5):1550-1565. doi: 10.1002/hep.32686. 

8.      Yang Z#, Xu X#, Gu C, Nielsen AV, Chen G, Guo F*, Tang C*, Zhao Y*.  Chemical Pretreatment Activated a Plastic State Amenable to Direct Lineage Reprogramming. Front Cell Dev Biol. 2022 Mar 25;10:865038. doi: 10.3389/fcell.2022.865038. 

9.      Zhao H, Zhang Y, Xu X, Sun Q, Yang C, Wang H, Yang J, Yang Y, Yang X, Liu Y*, Zhao Y*.  Sall4 and Myocd Empower Direct Cardiac Reprogramming From Adult Cardiac Fibroblasts After Injury. Front Cell Dev Biol. 2021 Feb 26;9:608367. doi: 10.3389/fcell.2021.608367.

10.   Yang Z#, Xu X#, Gu C#, Li J, Wu Q, Ye C, Nielsen AV, Mao L, Ye J, Bai K, Guo F*, Tang C*, Zhao Y*. Chemicals orchestrate reprogramming with hierarchical activation of mastertranscription factors primed by endogenous Sox17 activation. Commun Biol.  2020 Oct 30;3(1):629. doi: 10.1038/s42003-020-01346-w.

11.   Ye J#, Ge J#, Zhang X, Cheng L, Zhang Z, He S, Wang Y, Lin H, Yang W, Liu J, Zhao Y*, Deng H*. Pluripotent stem cells induced from mouse neural stem cells and small intestinal epithelial cells by small molecule compounds. Cell Res. 2016 Jan;26(1):34-45. doi: 10.1038/cr.2015.142.

12.   Zhao Y*#, Zhao T#, Guan J#, Zhang X#, Fu Y#, Ye J#, Zhu J, Meng G, Ge J, Yang S, Cheng L, Du Y, Zhao C, Wang T, Su L, Yang W, Deng H*. A XEN-like State Bridges Somatic Cells to Pluripotency during Chemical Reprogramming. Cell.  2015 Dec 17;163(7):1678-91. doi: 10.1016/j.cell.2015.11.017. 

13.   Li X#, Zuo X#, Jing J#, Ma Y, Wang J, Liu D, Zhu J, Du X, Xiong L, Du Y, Xu J, Xiao X, Wang J, Chai Z*, Zhao Y*, Deng H*. Small-Molecule-Driven Direct Reprogramming of Mouse Fibroblasts into Functional Neurons. Cell Stem Cell. 2015 Aug 6;17(2):195-203. doi: 10.1016/j.stem.2015.06.003.

14.   Hou P#, Li Y#, Zhang X#, Liu C#, Guan J#, Li H#, Zhao T, Ye J, Yang W, Liu K, Ge J, Xu J, Zhang Q, Zhao Y*, Deng H*. Pluripotent stem cells induced from mouse somatic cells by small-molecule compounds. Science. 2013 Aug 9;341(6146):651-4. doi: 10.1126/science.1239278.

15.   Shu J#, Wu C#, Wu Y#, Li Z#, Shao S, Zhao W, Tang X, Yang H, Shen L, Zuo X, Yang W, Shi Y, Chi X, Zhang H, Gao G, Shu Y, Yuan K, He W, Tang C*, Zhao Y, Deng H*. Induction of pluripotency in mouse somatic cells with lineage specifiers. Cell. 2013 May 23;153(5):963-75. doi: 10.1016/j.cell.2013.05.001. 

16.   Zhao Y#, Yin X#, Qin H#, Zhu F, Liu H, Yang W, Zhang Q, Xiang C, Hou P, Song Z, Liu Y, Yong J, Zhang P, Cai J, Liu M, Li H, Li Y, Qu X, Cui K, Zhang W, Xiang T, Wu Y, Zhao Y, Liu C, Yu C, Yuan K, Lou J, Ding M, Deng H*. Two supporting factors greatly improve the efficiency of human iPSC generation. Cell Stem Cell. 2008 Nov 6;3(5):475-9. doi: 10.1016/j.stem.2008.10.002. 

17.   Cai J#, Zhao Y#, Liu Y#, Ye F, Song Z, Qin H, Meng S, Chen Y, Zhou R, Song X, Guo Y, Ding M, Deng H*. Directed differentiation of human embryonic stem cells into functional hepatic cells. Hepatology. 2007 May;45(5):1229-39. doi: 10.1002/hep.21582.

 

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