Xun Lan

Tel: 62727512

Email: lan-lab@biomed.tsinghua.edu.cn

 

研究方向：

Constant immune surveillance prevents normal stem cells from uncontrolled proliferation; however, cancer cells evolve to evade the host immune system through various mechanisms. The immune genes related to “nonself” detection are extremely diverse in human population. Therefore, to better understand the mechanisms underlying immune escape and cancer development, it is important to use personalized approaches, which can integrate the genetic background of individual cancer patients. The Lan-Lab uses both experimental and computational approaches to study the interaction between cancer cells and the host immune system. We seek to gain insight into tumor immune escape, better understand the variability in patient response to cancer immunotherapies. We also use directed evolution to optimize the sensitivity and specificity of cancer cells recognition. Our ultimate goal is to improve the efficacy and prognosis of cancer immunotherapies by designing personalized treatment strategies.

 

Research Area: 

1．X. Lan* and J. K. Pritchard*, “Coregulation of tandem duplicate genes slows evolution of subfunctionalization in mammals,” Science, vol. 352, no. 6288, pp. 1009–1013, 2016.

2．B. Liu*, L. Fang, R. Long, X. Lan*, and K.-C. Chou*, “iEnhancer-2L: a two-layer predictor for identifying enhancers and their strength by pseudo k-tuple nucleotide composition,” Bioinformatics,2016

3．Z. Chen#, X. Lan#, J. M. Thomas-Ahner, D. Wu, X. Liu, Z. Ye, L. Wang, B. Sunkel, C. Grenade, J.Chen, et al., “Agonist and antagonist switch DNA motifs recognized by human androgen receptor in prostate cancer,” The EMBO Journal, 2015

4．Z. Chen, X. Lan, D. Wu, B. Sunkel, Z. Ye, J. Huang, Z. Liu, S. K. Clinton, V. X. Jin, and Q. Wang,“Ligand-dependent genomic function of glucocorticoid receptor in triple-negative breast cancer,”Nature Communications, vol. 6, 2015.

5．N. E. Banovich#, X. Lan#, G. McVicker, B. Van de Geijn, J. F. Degner, J. D. Blischak, J. Roux, J. K. Pritchard, and Y. Gilad, “Methylation QTLs are associated with coordinated changes in transcription factor binding, histone modifications, and gene expression levels,” PLoS Genetics, vol. 10, no. 9,e1004663, 2014.

6．P.-Y. Hsu, H.-K. Hsu, X. Lan, L. Juan, P. S. Yan, J. Labanowska, N. Heerema, T.-H. Hsiao, Y.-C. Chiu, Y. Chen, et al., “Amplification of distant estrogen response elements deregulates target genes associated with tamoxifen resistance in breast cancer,” Cancer Cell, vol. 24, no. 2, pp. 197–212, 2013

7．X. Lan, P. J. Farnham, and V. X. Jin, “Uncovering transcription factor modules using one-and three-dimensional analyses,” Journal of Biological Chemistry, vol. 287, no. 37, pp. 30 914–30 921,2012

8．X. Lan, H. Witt, K. Katsumura, Z. Ye, Q. Wang, E. H. Bresnick, P. J. Farnham, and V. X. Jin,“Integration of Hi-C and ChIP-seq data reveals distinct types of chromatin linkages,” Nucleic Acids Research, vol. 40, no. 16, pp. 7690–7704, 2012.