Xiaoliang Xie
Email： sunneyxie@gmail.com
Tel：01062752373
Research Area:
As a pioneer of single molecule biophysical chemistry, coherent Raman scattering microscopy, and single cell genomics, he made major contributions to the emergence of these fields. Furthermore, Xie has made advances on medical applications of label-free optical imaging and single cell genomics. In particular, his inventions for in vitro fertilization have benefited hundreds of couples in China in avoiding the transmission of their monogenic diseases to newborns. Prof. Xie’s current research interests include: 1) Scientific: single molecule enzymology, single molecule biophysical chemistry, gene expression and regulation, epigenetics, mechanism of cell differentiation and reprogramming, genomic instability; 2) Technological: single molecule imaging, single cell genomics, coherent Raman scattering microscopy, DNA sequencing; 3) Medical: preimplantation genetic screening and diagnosis in in vitro fertilization, early cancer diagnosis.
Selected Publications:
1. Chen C, Xing D, Tan L, Li H, Zhou G, Huang L, Xie X *(2017) "Single-cell whole-genome analyses by Linear Amplification via Transposon Insertion (LIANTI)," Science 356, 189-194.
2. Zhou Y, Wang P, Tian F, Gao G, Huang L, Wei W, Xie X *(2017)"Painting a specific chromosome with CRISPR/Cas9 for live-cell imaging," Cell Res 27, 298-301.
3. Fu D, Yang W, Xie X *(2017) "Label-free Imaging of Neurotransmitter Acetylcholine at Neuromuscular Junctions with Stimulated Raman Scattering," J Am Chem Soc 139, 583−586.
4. Yan L, Huang L, Xu L, Huang J, Ma F, Zhu X, Tang Y, Liu M, Lian Y, Liu P, Li R, Lu S, Tang F, Qiao J, Xie X *(2015) "Live births after simultaneous avoidance of monogenic diseases and chromosome abnormality by next-generation sequencing with linkage analyses," ProcNatlAcadSci USA 112, 15964-15969.
5. Chong S, Chen C, Ge H, Xie X* (2014) "Mechanism of Transcriptional Bursting in Bacteria," Cell 158, 314-326.
6. Hou Y, Fan W, Yan L, Li R, Lian Y, Huang J, Li J, Xu L, Tang F, Xie X *, Qiao J (2013)"Genome analyses of single human oocytes," Cell 155, 1492-1506.
7. Kim S, Brostromer E, Xing D, Jin J, Chong S, Ge H, Wang S, Gu C, Yang L, Gao Y, Su X, Sun Y, Xie X* (2013) "Probing Allostery Through DNA," Science 339, 816-819.
8. Zong C, Lu S, Chapman A, Xie X*(2012) "Genome-wide detection of single-nucleotide and copy-number variations of a single human cell," Science 338, 1622-1626.