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Zhixing Chen



Zhixing Chen





Research Area

As an emerging yet interdisciplinary field, bioimaging is revolutionizing biological and medical research. Trained as a general chemist, Dr. Chen has been approaching this field from a molecular aspect. Our lab endeavors to develop novel small-molecular, macro-molecular, and bio-molecular imaging probes by integrating the essence of chemical synthesis, spectroscopy, polymer chemistry, and chemical biology. The molecular probes would be applied as cutting-edge technologies to various fields including biophysics, cell biology, physiology, and finally inspire drug discovery. Our research philosophy features: 1. based on chemical principles, we customize tailored molecules as enabling solutions; 2. we leverage the platform of CLS as unique opportunities to bring modern molecular tools to the frontiers of biological sciences and molecular medicine. We believe our trainings in chemistry and biotechnology, our cross-disciplinary experience, and our problem-solving mindset would broaden the career path of trainees.


Selected Publications

1.      Chen, Z.; Mercer, J. A. M.; Zhu, X.; Romaniuk, J. A. H.; Pfattner, R.; Cegelski, L.; Martinez, T. J.; Burns, N. Z.; Xia, Y. Mechanochemical unzipping of insulating polyladderene to semiconducting polyacetylene. Science 2017357, 475-479 [Front Cover].

2.      Wei, L.; Chen, Z.; Shi, L.; Long, R.; Anzalone, A. V.; Zhang, L.; Hu, F.; Yuste, R.; Cornish, V. W.; Min, W. Super-multiplex vibrational imaging. Nature 2017544, 465-470. 

3.      Chen, Z.; Paley, D. W.; Wei, L.; Weisman, A. L.; Friesner, R. A.; Nuckolls, C.; Min, W. Multicolor Live-Cell Chemical Imaging by Isotopically Edited Alkyne Vibrational Palette. J. Am. Chem. Soc. 2014136, 8027–8033.

4.      Chen, Z.; Jing, C.; Gallagher, S. S.; Sheetz, M. P.; Cornish, V. W. Second-Generation Covalent TMP-Tag for Live Cell Imaging. J. Am. Chem. Soc. 2012134, 13692–13699.

5.      Xiao, Q.#; Ren, W.-W.#; Chen, Z.-X.; Sun, T.-W.; Li, Y.; Ye, Q.-D.; Gong, J.-X.; Meng, F.-K.; You, L.; Liu, Y.-F.; Zhao, M.-Z.; Xu, L.-M.; Shan, Z.-H.; Shi, Y.; Tang, Y.-F.; Chen, J.-H.; Yang, Z. Diastereoselective Total Synthesis of (±)-Schindilactone A. Angew. Chem. Int. Ed. Engl. 201150, 7373–7377 [Front Cover].

6.      Chen, Z.; Cornish, V. W.; Min, W. Chemical Tags: Inspiration for Advanced Imaging Techniques. Curr. Opin. Chem. Biol. 201317, 637–643.


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