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Yanan Du


Yanan Du

Email: duyanan@tsinghua.edu.cn

Tel: +86-10-62781691

Labweb:  http://dulab.med.tsinghua.edu.cn/


Research Area

We are working in the field of microtissue engineering, a unique and new research area, which integrates biomaterials, microfabrication technologies and mechanobiology to engineer microscale 3D tissues or microenvironments recapitulating the physiological and architectural features of native tissue niche with well-defined precision and bio-mimicry. Microtissue engineering provides powerful tools and solutions as well as theoretical models for cell/tissue engineering, regenerative medicine, drug screening and pathology study. We are working in highly inter-disciplinary and innovation-driven arena, providing unlimited opportunities for creative and ambitious minds. Some of our dreams include building functional liver/cardiovascular tissues; achieving better cell-based regenerative therapy to cure liver/cardiovascular/ diseases; discovering new pathological mechanisms and anti-fibrotic intervention strategies to alleviate chronic fibrosis-related symptoms.    .

Selected Publications

1.    Liu L, You Z, Yu H, Zhou L, Zhao H, Yan X, Li D, Wang B, Zhu L, Xu Y, Xia T, Shi Y, Huang C, Hou W, Du, Y*, ‘Mechanotransduction-modulated fibrotic microniches reveal the contribution of angiogenesis in liver fibrosis’ Nature Materials 16(12):1252-1261(2017)

2.    Yan X, Zhou L, Wu Z, Wang X, Chen X, Yang F, Guo Y, Wu M, Chen Y, Li W, Wang J*, Du Y*. ‘High throughput scaffold-based 3D micro-tumor array for efficient drug screening and chemosensitivity testing’. Biomaterials. 2018 May doi: 10.1016/j.biomaterials.2018.05.020

3.    Fan X, Zhu L, Wang K, Wang B, Wu Y, Xie W, Huang C, Chan BP, Du Y* ‘Stiffness-Controlled Thermoresponsive Hydrogels for Cell Harvesting with Sustained Mechanical Memory’ Adv Healthc Mater. Mar;6(5) doi:10.1002/adhm.201601152. (2017)

4.    Qi C, Li Y, Badger P, Yu H, You Z, Yan X, Liu W, Shi Y, Xia T, Dong J, Huang C, Du Y*, ‘Pathology-targeted cell delivery via injectable micro-scaffold capsule mediated by endogenous TGaseBiomaterials 126:1-9 (2017)

5.    Zhu L, Fan X, Wang B, Liu L, Yan X, Zhou L, Zeng Y, Poznansky MC, Wang L, Chen H, Du Y*Biomechanically primed liver microtumor array as a high-throughput mechanopharmacological screening platform for stroma-reprogrammed combinatorial therapyBiomaterials 124:12-24 (2017)

6.    Wang J, Chen F, Liu L, Qi C, Wang B, Yan X, Huang C, Hou W, Zhang M, Chen Y*, Du Y* Engineering EMT using 3D Micro-scaffold to Promote Hepatic Functions for Drug Hepatotoxicity EvaluationBiomaterials 91:11-22 (2016)

7.    Zeng Y, Chen C, Liu W, Fu Q, Han Z, Li Y, Feng S, Li X, Qi C, Wu J, Wang D, Corbett C, Chan BP, Ruan D*, Du Y*.  Injectable Microcryogels Reinforced Alginate Encapsulation of Mesenchymal Stromal Cells for Leak-proof Delivery and Alleviation of Canine Disc Degeneration’ Biomaterials  59:53-65  (2015)

8.    Zhao H, Zhou L, Zhang Q, Zhou X, Zhang Y, Chen H, Du Y* Bi-content micro-collagen chip provides contractility-based biomechanical readout for phenotypic drug screening with expanded and profiled targetsLab Chip, 15(17):3481-94 (2015)

9.    Li Y, Liu W, Liu F, Zeng Y, Zuo S, Feng S, Qi C, Wang B, Khademhosseini A, Bai J, Du Y* ‘Primed 3D Injectable Micro-Niches Enabling Low-dosage Cell Therapy for Critical Limb Ischemia’ PNAS 111(37):13511-6 (2014)

10. Liu W, Li Y, Feng S, Ning J, Chen H, Feng X, Du Y*Magnetically Controllable 3D Microtissues based on Magnetic microcryogels’ Lab on Chip (cover) 4(15):2614-25 (2014)

11. Zhao S, Zhao H, Zhang X, Li Y, Du Y* ‘Off-the-shelf Microsponge Arrays for Facile and Efficient Construction of 3D Cellular Microenvironment for Versatile cell-based assays’ Lab on Chip 13(12):2350-8 (2013)



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