Web Map For Collection 中文 English
 
Home About us Organization Principal Investigators Research Education& Training Academic activities Facilities Careers Downloads Contact us
Location:Home - Principal Investigators
Hang Hubert Yin

 

Hang Hubert Yin

 

Emailyin_hang@tsinghua.edu.cn

 

Research Area:

Chemical Biology

Drug Discovery

 

Professor Hang Hubert Yin was born in Beijing in 1976. After studying for a bachelor's degree at Peking University, he received his PhD from Yale University in 2004 under the supervision of Professor Andrew Hamilton and then spent a post-doctoral period at the University of Pennsylvania School of Medicine with Professor William DeGrado. In 2018, Professor Yin joined the School of Pharmaceutical Sciences at Tsinghua University as a founding Deputy Dean. Prior to joining Tsinghua, he was a tenured faculty member of the University of Colorado Boulder.

 

His research interests lie at the interface of chemistry, biology, and engineering with particular focuses on structure-based drug design, extracellular vesicles, cell signaling biochemistry, biotechnology development, and membrane protein simulations. Professor Yin is a recipient of many accolades for his research in chemical biology and drug discovery, including the Wu Jieping-Paul Janssen Medical & Pharmaceutical Award, American Chemical Society David W. Robertson Award for Excellence in Medicinal Chemistry, OKeanos-CAPA Senior Investigator Award, National Science Fund for Distinguished Young Scholars, Beijing Outstanding Young Scientist, CAPA Distinguished Junior Faculty Award, NSF CAREER Award, AACR Gertrude B. Elion Cancer Research Award, Sidney Kimmel Scholars Award, and HHMI Collaborative Innovation Award among others. Professor Yin’s is currently serving as a member of the Academic Committee of Tsinghua University, an advisor of the Chinese Society of Extracellular Vesicles (CSEV), the Editor-in-Chief of Bioorganic and Medicinal Chemistry Letters, a deputy editor of the Journal of Extracellular Vesicles, and an advisory board member of Cell Chemical Biology.

 

Lab website:

 

http://www.yinlab-tsinghua.cn/

 

 

Selected publications in last 5 years (H-index=61, citation >20,000)

1. Su, C.; Cheng, T.; Huang, J.; Zhang, T.; *Yin, H. “4-Octyl Itaconate Restricts STING Activation by Blocking Its Palmitoylation”, Cell Rep. 2023, 42, e113040.

2. Jin, X.; Xia, T.; Luo, S.; Zhang, Y.; Xia, Y.; *Yin, H. “Exosomal Lipid PI4P Regulates Small Extracellular Vesicle Secretion by Modulating Intraluminal Vesicle Formation”, J. Extracell. Vesicles 2023, 12, 12319.

3. Liang, J.; *Yin, H. “STAM Transports STING Oligomers into Extracellular Vesicles Down-Regulating the Innate Immune Response”, J. Extracell. Vesicles 2023, 12, e12316.

4. *Yin, H.; Fan, C.; Huang, Y.; *Chen, G. “Innovative Chemistry Research Driven by Medicine”, Fundamental Res. 2023, 3, 479-480.

5. Zhang, L.; Wei, X.; Wang, Z.; Liu, P.; Hou, Y.; Xu, Y.; Su, H.; Koci, M. D.; *Yin, H; *Zhang, C. “NF-κB Activation Enhances STING Signaling by Altering Microtubule-Mediated STING Trafficking”, Cell Rep. 2023, 42, e112185.

6. Cell Derived Small Extracellular Vesicles”, Interdisciplinary Med. 2023, 1, e20220015.

7. Shi, S.; Yang, X.; Hou, Y.; Jin, X.; Guo, L.; Zhou, Y.; Zhang, C.; *Yin, H. “USP15 Promotes cGAS Activation through Deubiquitylation and Liquid Condensation”, Nucleic Acid Res. 2022, 50, 11093-11108.

8. Li, Y.; Pu, D.; Huang, J.; Zhang, Y.; *Yin, H. “Protein Phosphatase 1 Regulates Phosphorylation of Gasdermin D and Pyroptosis”, Chem. Comm. 2022, 58, 11965-11968.

9. Shi, S.; Yang, X.; Liu, Y.; Li, H.; Chu, H.; Li. G.; *Yin, H. “ZDHHC18 Negatively Regulates cGAS-Mediated Innate Immunity Through Palmitoylation”, EMBO J. 2022, 41, e109272.

10. Yang, X.; Shi, S.; Shen, S.; Li, H.; Su, C.; *Yin, H. “MARCH8 Attenuates cGAS-Mediated Innate Immune Responses Through Ubiquitylation”, Sci. Signal. 2022, 15, eabk3067 ((highlighted in “This Week in ScienceScience 2022, 376, 593).

11. Yang, Y.; Csakai, A.; Jiang, S.; Smith, C.; Tanji, H.; Huang, J.; Jones, T.; Sakaniwa, K; Broadwell, L.; Shi, C.; Soti, S.; Ohto, U.; Fang, Y.; Shen, S.; Deng, F.; Shimizu, T.; *Yin, H. “Tetrasubstituted Imidazoles as Incognito Toll-like Receptor 8 A(nta)gonists”, Nat. Commun. 2021, 12, 4351(featured in the Editor’s Highlights to showcase among the 50 best papers in Organic Chemistry and Chemical Biology).

12. Huang, J.; Yuan, Y.; Zhao, N.; Pu, D.; Tang, Q.; Zhang, S.; Luo, S.; Yang, X.; Wang, N.; Xiao, Y.; Zhang, T.; Liu. Z.; Sakata-Kato, Y.; Hirata, K.; *Jiang, X.; *Kato, N.; *Yan, N.; *Yin, H. “Orthosteric-Allosteric Dual Inhibitors of PfHT1 as Selective Anti-Malarial Agents”, Proc. Natl. Acad. Sci. U. S. A. 2021, 118, e2017749118.

13. Wang, J.; Shi, C.; Xu, Q.; *Yin, H. “SARS-CoV-2 Nucleocapsid Protein Undergoes Liquid-Liquid Phase Separation into Stress Granules through Its N-Terminal Intrinsically Disordered Region”, Cell Discov. 2021, 7, 5.

14. Zhang, Y.; Xiao, Y.; Sun, G.; Jin, X.; Guo, L.; Li, T.; *Yin, H. “Harnessing the Therapeutic Potential of Extracellular Vesicles for Cancer Treatment”, Semin. Cancer Biol. 2021, 74, 92-104.

15. Jiang, X.; Yuan, Y.; Huang, J.; Zhang, S.; Luo, S.; Wang, N.; Pu, D.; Zhao, N.; Tang, Q.; Hirata, K.; Yang, X.; Jiao, Y.; Sakata-Kato, Y.; Wu, J.; Yan, C.; Kato, N.; *Yin, H.; *Yan, N. “Structural Basis for Blocking Sugar Uptake into the Malaria Parasite Plasmodium falciparum”, Cell 2020, 183, 258-268.

16. Xu, Q.; Dai, C.; Kong, J.; Chen, H.; Feng, J.; Zhang, Y.; *Yin, H. “Immune Profiling Before Treatment is Predictive of TLR9-Induced Antitumor Efficacy”, Biomaterials 2020, 263, 120379.

17. Xiao, Y.; Driedonks, T.; Witwer, K.; Wang, Q.; *Yin, H. “How Does an RNA Selfie Work? EV-Associated RNA in Innate Immunity as Self or Danger”, J. Extracell. Vesicles 2020, 9, e1793515.

18. Wang, Y.; Zhang, S.; Li, H.; Wang, H.; Zhang, T.; Hutchinson, M.; *Yin, H.; *Wang, X. “Small Molecule Modulators of Toll-Like Receptors”, Acc. Chem. Res. 2020, 53, 1046-1055 (cover article).

19. Gao, M.; Huang, J.; Jiang, X.; Yuan, Y.; Luo, S.; Wang, N.; Pang, H.; Deng, D.; Yao, C.; Lin, Z.; Pu, D.; Liu, Z.; Hu, Z.; *Yin, H. “Regulation of Aerobic Glycolysis to Decelerate Tumor Proliferation by Small Molecule Inhibitors Targeting Glucose Transporters”, Protein Cell 2020, 11, 446-451.

20. Zhang, Y.; Jin, X.; Liang, J.; Guo, Y.; Sun, G.; Zeng, X.; *Yin, H. “Extracellular Vesicles Derived from ODN-Stimulated Macrophages Promote Their Cellular Uptake by the Transfer and Activation of Cdc42”, Sci. Adv. 2019, 5, eaav1564.

21. Hu, Z.; Tanji, H.; Jiang, S.; Zhang, S.; Koo, K.; Chan, J.; Sakaniwa, K.; Ohto, U.; Candia, A.; Shimizu, T.; *Yin, H. “Small Molecule TLR8 Antagonists via Structure-Based Rational Design”, Cell Chem. Biol. 2018, 25, 1286-1291 (cover article).

22. Bhattacharyya, S.; Wang, W.; Qin, W.; Cheng, K.; Coulup, S.; Chavez, S.; Raparia, K.; De Almeida, L. M.; Stehlik, C.; Tamaki, Z.; *Yin, H.; *Varga, J. “TLR4-Dependent Fibroblast Activation Drives Persistent Organ Fibrosis in Skin and Lung”, JCI Insight 2018, 3, e98850 (featured in “News & ViewsNat. Rev. Rheumatol. 2018, 14, 564-566).

23. Zhang, S.; Hu, Z.; Tanji, H.; Jiang, S.; Das, N.; Li, J.; Sakaniwa, K.; Jin, J.; Bian, Y.; Ohto, U.; Shimizu, T.; *Yin, H. “Small Molecule Inhibition of TLR8 through Stabilization of Its Resting State”, Nat. Chem. Biol. 2018, 14, 58-64 (cover article; featured as C&EN “Latest News”).

 

 

All right reserved Center For Life Sciences