Hang Hubert Yin
Professor and Deputy Dean, School of Pharmaceutical Sciences, Tsinghua University, Beijing China
Research Area
Chemical Biology
Membranes Biophysics
Medicinal Chemistry
Education & Training: B.S.: Peking University (1999); Ph.D.: Yale University (2004); Postdoc: University of Pennsylvania School of Medicine (2004 - 2007)
Selected Awards and Honors: National Science Fund for Distinguished Young Scholars, National Natural Science Foundation of China (2018); Bayer Investigator Award (2018); ACS David W. Robertson Award, American Chemical Society (2016); CAPA Distinguished Junior Faculty Award (2012); NSF CAREER Award (2010); SU2C IRG Award (2010); AACR Gertrude B. Elion Award (2009); NIDA Early Career Award in Chemistry of Drug Abuse and Addiction (2009); NIDA Cutting-Edge Basic Research Award (2009); HHMI Collaborative Innovation Award (2009); Kimmel Scholars Award (2008); IUBMB Wood-Whelan Fellowship (2007)
Selected Recent Publications:
1. Zhang, S.; Hu, Z.; Tanji, H.; Jiang, S.; Das, N.; Li, J.; Sakaniwa, K.; Jin, J.; Bian, Y.; Ohto, U.; Shimizu, T.; *Yin, H. “Small Molecule Inhibition of TLR8 through Stabilization of Its Resting State”, Nat. Chem. Biol. 2018, 14, 58-64 (cover article; featured in C&EN “Latest News”).
2. Hu, Z.; Tanji, H.; Jiang, S.; Zhang, S.; Koo, K.; Chan, J.; Sakaniwa, K.; Ohto, U.; Candia, A.; Shimizu, T.; *Yin, H. “Small Molecule TLR8 Antagonists via Structure-Based Rational Design”, Cell Chem. Biol. 2018, 25, 1286-1291(cover article).
3. Bhattacharyya, S.; Wang, W.; Qin, W.; Cheng, K.; Coulup, S.; Chavez, S.; Raparia, K.; De Almeida, L. M.; Stehlik, C.; Tamaki, Z.; *Yin, H.; *Varga, J. “TLR4-Dependent Fibroblast Activation Drives Persistent Organ Fibrosis in Skin and Lung”, JCI Insight 2018, 3, e98850 (featured in “News & Views” Nat. Rev. Rheumatol. 2018, 14, 564-566).
4. Zhang, L.; Shi, L.; Soars, S. M.; Kamps, J.; *Yin, H. “Discovery of Novel Small-Molecule Inhibitors of NF-κB Signaling with Anti-Inflammatory and Anti-Cancer Properties”, J. Med. Chem. 2018, 61, 5881-5899.
5. Zhang, L.; Dewan, V.; *Yin, H. “Discovery of Small Molecules as Multi-TLR Agonists with Proinflammatory and Anticancer Activities”, J. Med. Chem. 2017, 60, 5029-5044.
6. Smith, C. E.; Soti, S.; Jones, T. A.; Nakagawa, A.; Xue, D.; *Yin, H.“NSAIDs are Caspase Inhibitors”, Cell Chem. Biol. 2017, 24, 281-292 (featured in “Concentrates” C&EN 2017, 95(10), 10; NIH Research Matters; The Sun; Daily Mail).
7. Das, N.; Dewan, V.; Grace, P. M.; Gunn, R. J.; Tamura, R.; Tzarum, N.; Watkins, L. R.; Wilson, I. A.; *Yin, H. “HMGB-1 Activates Proinflammatory Signaling via TLR5 Leading to Allodynia”, Cell Rep. 2016, 17, 1128-1140.
8. *Yin, H.; Flynn, A.D. “Drugging Membrane Protein Interactions”, Annu. Rev. Biomed. Eng. 2016, 18, 51-76.
9. Wang, T.; de Jesus, A.; *Shi, Y.; *Yin, H.; “Pyridoxamine is a substrate of the energy-coupling factor transporter HmpT", Cell Discov. 2015, 1, 15014.
10. Daniele, S. G.; Beraud, D.; Davenport, C.; Cheng, K.; *Yin, H.; *Maguire-Zeiss, K. A.; “Activation of MyD88-Dependent TLR1/2 Signaling by Misfolded α-Synuclein, a Protein Linked to Neurodegenerative Disorders”, Sci. Signal. 2015, 8, ra45 (highlighted in “This Week in Science” Science 2015, 348, 769; Podcast: Maguire-Zeiss, K. A.; Daniele, S. G.; Yin, H.; VanHook, A. M.; Sci. Signal. 2015, 8, pc12; feature story by the Xinhua News Agency).
11. Cheng, K.; Gao, M.; Godfroy, J. I. III; Brown, P. N.; Kastelowitz, N.; *Yin, H.; “Specific Activation of the TLR1-TLR2 Heterodimer by Small-molecule Agonists”, Sci. Adv. 2015, 1, e1400139 (featured in “Science & Technology” C&EN 2015, 93(15), 39-40).
12. Smith, C. E.; Wang, X. H.; *Yin, H.; “Caspases Come Together Over LPS”, Trends Immunol. 2015, 36, 59-61.
13. Yang, H.; Chen, Y. Z.; Zhang, Y.; Wang, X. H.; Zhao, X.; Godfroy, J. I.; Liang, Q.; Zhang, M.; Zhang, T.; Yuan, Q.; Royal, M. A.; Driscoll, M.; Xia, N. S.; Yin, H.; Xue, D. “A Lysine-Rich Motif in the Phosphatidylserine Receptor PSR-1 Mediates Recognition and Removal of Apoptotic Cells”, Nat. Commun. 2015, 6, 5717.
14. Csakai, A.; Smith, C.; Davis, E.; Martinko, A.; Coulup, S.; *Yin, H. “Saccharin Derivatives as Inhibitors of Interferon-Mediated Inflammation”, J. Med. Chem. 2014, 57, 5348-5355 (cover article).
15. Wang, X. H.; Grace, P. M.; Pham, M. N.; Cheng, K.; Strand, K. A.; Smith, C. E.; Li, J.; Watkins, L. R.; *Yin, H. “Rifampin Inhibits Toll-like Receptor 4 Signaling by Targeting Myeloid Differentiation Protein 2 and Attenuates Neuropathic Pain”, FASEB J. 2013, 27, 2713-2722.
16. Wang, X. H.; Smith, C.; *Yin, H. “Targeting Toll-Like Receptors with Small Molecule Agents”, Chem. Soc. Rev. 2013, 42, 4859-4866 (cover article).
17. Brown, P. N.; *Yin, H. “PNA-Based MicroRNA Inhibitors Elicit Anti-Inflammatory Effects in Microglia Cells”, Chem. Commun. 2013, 49, 4415-4417 (2013 Emerging Investigators issue).
18. Morton, L. A.; Saludes, J. P.; Beninson, L.; Chapman, E. R.; Fleshner, M.; *Yin, H. “MARCKS-ED Peptide as a Membrane Curvature Sensor”, ACS Chem. Biol. 2013, 8, 218-225.
19. Cheng, K.; Wang, X. H.; Zhang, S.; *Yin, H. “Discovery of Small-Molecules that Inhibit the Protein Complex of Toll-Like Receptor 1 and 2”, Angew. Chem. Int. Ed. 2012, 51, 12246-12249 (cover article; featured in “Science & Technology Concentrates” C&EN 2012, 90(35), 33).
20. Saludes, J. P.; Morton, L. A.; Ghosh, N.; Beninson, L.; Chapman, E. R.; Fleshner, M.; *Yin, H. “Detection of Highly Curved Membrane Surfaces Using a Cyclic Peptide Derived from Synaptotagmin-I”, ACS Chem. Biol. 2012, 7, 1629-1635.
21. Wang, X. H.; Loram, L. C.; Ramos, K.; de Jesus, A.; Thomas, J.; Cheng, K.; Reddy, A.; Somogyi, A. A.; Hutchinson, M. R.; Watkins, L. R.; *Yin, H. “Morphine Activates Neuroinflammation in a Parallel Manner to Endotoxin”, Proc. Natl. Acad. Sci. U. S. A. 2012, 109, 6325-6330(highlighted in “Research Highlights This Week” Nature 2012, 484, 419; “This Week in PNAS”; Sci. Signal. Editors’ Choice; featured on the website of the Association of American Universities;
22. Chavez, S. A.; Martinko, A. J.; Lau, C.; Pham, M. N.; Cheng, K.; Mollnes, T. E.; *Yin, H. “Development of β–Amino Alcohol Derivatives that Inhibit TLR4-Mediated Inflammatory Response as Potential Antiseptics”, J. Med. Chem. 2011, 54, 4659-4669 (headlined in Global Medical Discovery).
23. Cheng, K.; Wang, X. H.; *Yin, H. “Small Molecule Inhibitors of the TLR3/dsRNA Complex”, J. Am. Chem. Soc. 2011, 133, 3764-3767.
24. *Yin, H. “Exogenous Agents that Target Transmembrane Domains of Proteins”, Angew. Chem. Int. Ed. 2008, 47, 2744-2752 (cover article).
25. Yin, H.; Slusky, J. S; Berger, B. W.; Walters, R. S.; Vilaire, G.; Litvinov, R. I.; Lear, J. D.; Caputo, G. A.; Bennett, J. S.; DeGrado, W. F. “Computational Design of Peptides that Target Transmembrane Helices”, Science 2007, 315, 1817-1822 (featured in “News of the Week” C&EN2007, 85, 11; “News and Views” Nat. Biotech. 2007, 25, 646; and “Editors’ Choice” Sci. Signal. 2007, 2007, tw119).