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Catherine CL Wong



Catherine CL Wong



Research Area

1. Development of cutting-edge mass spectrometry technologies, including single cell proteomics, new methods on glycoproteins identifications and quantifications based on Trapped Ion Mobility-TOF MS and new protein database search algorithms development.

2. Biomarker exploration based on disease problems and clinical cohorts using multi-omics technologies, combined with biotechnology, chemical biology and other interdisciplinary technologies for functional verification and mechanism analysis. 


Selected Publications

1. Li, Z. Y., Huang, M., Wang, X. K., Zhu, Y., Li, J. S., Wong, C. C. L.,* Fang, Q*., Nanoliter-Scale Oil-Air-Droplet Chip-Based Single Cell Proteomic Analysis. Anal Chem, 2018, 90(8):5430-5438.
2. Tao, Z., Meng, X., Han, Y. Q.., Xue, M. M., Wu, S., Wu, P., Yuan, Y., Qiang, Z., Zhang, T.-J.* and Wong, C. C. L.,* Therapeutic Mechanism Studies of ShuFengJieDu Capsule on an Acute Lung Injury Animal Model Using Quantitative Proteomics Technology, Journal of proteome research, 2017, 16(11):4009-4019.
3. Liu, M.-Q., Zeng, W.-F., Fang, P., Cao, W.-Q., Liu, C., Yan, G.-Q., Zhang, Y., Peng, C., Wu, J.-Q., Zhang, X.-J., Tu, H.-J., Chi, H., Sun, R.-X., Cao, Y., Dong, M.-Q., Jiang, B.-Y., Huang, J.-M., Shen, H.-L., Wong, C. C. L.,* He, S.-M.* and Yang, P.-Y.* , pGlyco 2.0 enables precision N-glycoproteomics with comprehensive quality control and one-step mass spectrometry for intact glycopeptide identification, Nature Communications, 2017, 8(1):438
4. Hao, Q., Jiao, S., Shi, Z., Li, C., Meng, X., Wang, W., Song, X., Jiang, Z., Zhao, Y., Wong, C. C. L.,* and Zhou, Z.,* A non-canonical role of the p97 complex in RIG-I antiviral signaling, EMBO Journal, 2015, 34(23):2903-2920
5. Yan, C., Huang, J., Wan, R., Huang, M., Wong, C. C. L., and Shi, Y., Structure of a yeast Spliceosome at 3.6-angstrom resolution, Science, 2015, 349(6253):1182-1191
6. Keck, J. M., Jones, M. H., Wong, C. C. L., Binkley, J., Chen, D., Holinger, E. P., Niepel, M., Rout, M., Vogel, J., Sidow, A., Yates 3rd, J. R., and Winey, M., A Cell Cycle Phosphoproteome of the Yeast Centrosome, Science, 2011, 332(6037):1557-1561
7. Xu, T#., Wong, C. C. L.#(co-first Author), Kashina, A., and Yates 3rd, J. R., Identification of N-terminally Arginylated Proteins and Peptides by Mass Spectrometry, Nature Protocol, 2009, 4(3):325-332
8. Wong, C. C. L, Xu, T., Rai, R., Bailey, A. O., Yates 3rd, J. R., Wolf, Y. I., Zebroski, H., and Kashina, A., Global Analysis of Posttranslational Protein Arginylation, PloS Biol, 2007, 5(10), 2231-42.




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