Peng Jiang, Ph.D
Email: pengjiang@tsinghua.edu.cn
Research Area
Tumour and immune cell metabolism. The metabolism within and outside of tumour cells is markedly different from that of normal cells in differentiated tissues. Metabolic reprogramming usually confers pro-proliferative and/or survival advantages to tumour cells. Emerging evidence suggest that metabolic alteration is ultimately linked to genetic changes that contribute to cell fate decisions. Currently, we are interested in how cancer cells rewire their metabolism, particularly the role of the most frequently mutated gene p53 in tumour cell metabolism. We are also interested in how nutrient alteration or changes in microenvironmental metabolites is sensed by cancer and immune cells, and how metabolic remodeling influences anti-tumour immune responses. Understanding these issues will have great value for defining and targeting a therapeutic window for treating cancer.
Selected Publications:
1. Cheng, J#, Liu, Y#, Yan, J#, Zhao L, Zhou Y, Shen X, Y, Chen Y, Meng X, Zhang X* & Jiang P*. Fumarate suppresses B-cell activation and function through direct inactivation of LYN. Nature Chemical Biology (2022). https://doi.org/10.1038/s41589-022-01052-0
2. Zhao M#, Yao P#, Mao Y#, Wu J#, Wang W, Geng C, Cheng J, Du W * and Jiang P*. Malic enzyme 2 maintains protein stability of mutant p53 through 2-hydroxyglutarate. Nature Metabolism. (2022) Feb 28；4(2):225-238.
3. Mao Y, Shi D, Li G, Jiang P*. Citrulline depletion by ASS1 is required for proinflammatory macrophage activation and immune responses. Molecular Cell. (2022) Feb 3;82(3):527-541. Epub 2022 Jan 10.
4. Wu J#, Li G#, Li D, Zhou J, Dong Z, Jiang P*. Detection of CD8+ T cell-mediated immune responses to bacterial infection in mice. STAR Protoc. (2021) Dec 13;2(4):101022.
5. Li G#, Wu J#, Li L, Jiang P*. p53 deficiency induces MTHFD2 transcription to promote cell proliferation and restrain DNA damage. Proc Natl Acad Sci U S A. (2021) Jul 13;118(28)
6. Wu J#, Li G#, Li L, Li D, Dong Z, Jiang P*. Asparagine enhances LCK signalling to potentiate CD8+ T cell-activation and anti-tumour responses. Nature Cell Biology, (2021) 23(1):75-86.
7. Deng L, Yao P, Li L, Ji F, Zhao S, Xu C, Lan X, Jiang P*. p53-mediated control of aspartate-asparagine homeostasis dictates LKB1 activity and modulates cell survival. Nature Communications, (2020) 11, 1755-18.
8. Li L, Mao Y, Zhao L, Li L, Wu J, Zhao M, Du W, Yu L, Jiang P*. p53 regulation of ammonia metabolism through urea cycle controls polyamine biosynthesis. Nature. (2019) 567(7747):253-256.
9. Li L#, Li L#, Li W, Chen T, Bin Zou, Zhao L, Wang H, Wang X, Xu L, Liu X, Wang D, Li B, Mak TW, Du W*, Yang X*, Jiang P*. TAp73-induced phosphofructokinase-1 transcription promotes the Warburg effect and enhances cell proliferation. Nature Communications. (2018), Nov 8; 9(1):4683.
10. Yao P, Sun H, Xu C, Chen T, Zou B, Jiang P*, Du W*. Evidence for a direct cross-talk between malic enzyme and the pentose phosphate pathway via structural interactions. J Biol Chem. (2017) Oct 13; 292(41):17113-17120.
11. Du W#, Jiang P#, Mancuso A, Stonestrom A, Brewer M, Minn AJ, Mak TW, Wu M* and Yang X*. TAp73 enhances the pentose phosphate pathway and supports cell proliferation. Nature Cell Biology. (2013), Aug. 15, 991–1000.
12. Jiang P#, Du W#, Mancuso A, Wellen KE, Yang X*. Reciprocal regulation of p53 and malic enzymes modulates metabolism and senescence. Nature. (2013), Jan. 493: 689-693.
13. Jiang P#, Du W#, Wang X, Mancuso A, Gao X, Wu M* and Yang X*. p53 regulates biosynthesis through direct inactivation of glucose-6-phosphate dehydrogenase. Nature Cell Biology. (2011) Mar.13: 310-316.