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Peng Jiang

 

Peng Jiang

Email: pengjiang@tsinghua.edu.cn

 

Research Area

Cancer Metabolism It has become increasingly clear that a new important hallmark of tumour cells is the re-organization of their metabolic pathways, which is thought to provide biomass for cancer cell proliferation and to protect them against oxidative damages they inevitably experienced. The altered metabolic reprogramming and oncogene/tumour suppressor mutations are thought to be two primary causes for many human cancer diseases. Growing evidence indicate that metabolic dysregulation is significantly linked to genetic mutations of oncogene/tumour suppressor and contributes to cell fate decisions. However, it remains a mystery as to how exactly metabolism is altered in cancer cells and what advantages these alterations afford. Moreover, the metabolism within and outside of tumor cells is markedly different from that of normal cells in differentiated tissues. Thus, we currently are interested in how cancer cells rewire their metabolism, and how nutrient and metabolite alteration is sensed by cancer cells. We are also interested in how metabolism remodeling influences anti-tumour immune responses. Understanding these issues will have great value for defining and targeting a therapeutic window for treating cancer.

 

Selected Publications

1.       Li L, Mao Y, Zhao L, Li L, Wu J, Zhao M, Du W, Yu L, Jiang P*. p53 regulation of ammonia metabolism through urea cycle controls polyamine biosynthesis. Nature. (2019) Mar 6; 567(7747):253-256.

2.       Li L#, Li L#, Li W, Chen T, Bin Zou, Zhao L, Wang H, Wang X, Xu L, Liu X, Wang D, Li B, Mak TW, Du W*, Yang X*, Jiang P*. TAp73-induced phosphofructokinase-1 transcription promotes the Warburg effect and enhances cell proliferation. Nature Communications. (2018), Nov 8; 9(1):4683.

3.       Yao P, Sun H, Xu C, Chen T, Zou B, Jiang P*, Du W*. Evidence for a direct cross-talk between malic enzyme and the pentose phosphate pathway via structural interactions. J Biol Chem. (2017) Oct 13;292(41):17113-17120.

4.       Du W#, Jiang P#, Mancuso A, Stonestrom A, Brewer M, Minn AJ, Mak TW, Wu M* and Yang X*. TAp73 enhances the pentose phosphate pathway and supports cell proliferation. Nature Cell Biology. (2013), Aug. 15, 991–1000.

5.       Jiang P#, Du W#, Mancuso A, Wellen KE, Yang X*. Reciprocal regulation of p53 and malic enzymes modulates metabolism and senescence. Nature. (2013), Jan. 493: 689-693.

6.       Jiang P#, Du W#, Wang X, Mancuso A, Gao X, Wu M* and Yang X*. p53 regulates biosynthesis through direct inactivation of glucose-6-phosphate dehydrogenase. Nature Cell Biology. (2011) Mar.13: 310-316.

 (*corresponding author, # co-first author)

 

 

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