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Jun-Jie Liu

Jun-Jie (Gogo) Liu, Ph.D.


2007-2011B.S.,  School of Life Sciences, Sichuan University

2011-2016Ph.D., Peking University-Tsinghua University-NIBS Joint Ph.D. Program

2016-2018Postdoctoral Fellow, MBIB Division, Lawrence Berkeley National Laboratory

2018-2020Postdoctoral Fellow, Department of Molecular and Cell biology, UC Berkeley

2018-2020Life Science Research Fund Fellow Sponsored by Pfizer

2020,10-       Tenure-Track Assistant Professor, School of Life Sciences, Tsinghua University


Research Interest:

The Liu lab uses multidisciplinary approaches to study the following topics:

(1)    Co-evolution of RNA and protein in RNP system with essential function across life domains.

(2)    Identification, evolution study and application development of new CRISPR systems

(3)    Functional and structural study of human disease related LncRNA and the development of new therapy method.


Selected Publications:

1. Liu JJ#, Wang HW#. (2020) Cryo-Electron Microscopy of Endogenous Yeast Exosomes. Methods Mol. Biol., 2062:401-415. (Book Chapter, Corresponding Author)

2. Liu TY*, Liu JJ*, Aditham AJ, Nogales E, Doudna JA. Target preference of Type III A CRISPR-Cas complexes at the transcription bubble. Nature Communications,10(1), 3001(2019). (Co-first author)

3.  Liu JJ, Orlova N, Oakes BL, Ma E, Spinner HB, Baney KLM, Chuck J, Tan D, Knot GJ, Harrington L, Al-Shayeb B, Wanger A, Brotzmann J, Staahl BT, Taylor KL, Desmarais J, Nogales E, Doudna JA. CasX enzymes comprise a distinct family of RNA-guided genome editors. Nature, 566,218-223 (2019). 

4. Jiang F*, Liu JJ*, Osuna BA*, Xu M, Berry JD, Rauch BJ, Nogales E, Denomy JB, Doudna JA. Temperature-responsive competitive inhibition of CRISPR-Cas9. Molecular Cell, 1016-016(2018). (Co-first author)

5. Wright AV*, Liu JJ*, Knott GJ, Doxzen KW, Nogales E, Doudna JA. Structures of the CRISPR genome integration complex. Science, 357, 1113-1118 (2017). (Co-first author)

6. Shing J*, Jiang F*, Liu JJ*, Bray NL, Rauch BJ, Baik SH, Nogales E, Bondy-Denomy J, Corn JE, Doudna JA. Disabling Cas9 by an anti-CRISPR DNA mimic. Science Advances, 3(7): e1701620(2017). (Co-first author)

7. Ma M*, Liu JJ*, Li Y, Huang Y, Ta N, Chen Y, Fu H, Ye MD, Ding Y, Huang W, Wang J, Dong MQ, Yu L, Wang HW. Cryo-EM structure and biochemical analysis reveal the basis of the functional difference between human PI3KC3-C1 and-C2. Cell Research, 27,989-1001(2017). (Co-first author)

8. Liu JJ, Niu CY, Wu Y, Tan D, Wang Y, Ye MD, Dong MQ, Huang N & Wang HW, CryoEM structure of yeast cytoplasmic exosome complex, Cell Research, 26, 822-837(2016).

9. Liu JJ, Bratkowski MA, Liu XQ, Niu CY, Ke AL & Wang HW, Visualization of distinct substrate-recruitment pathways in the yeast exosome by EM, Nature Structural & Molecular Biology, 21, 95–102 (2014).

10. Liu JJ, Lin M, Yu JY, Liu B, Bao JK. Targeting apoptotic and autophagic pathways for cancer therapeutics. Cancer Letters, 300(2):105-114 (2011).


Contact info:


Tel+86-010-62770270 (lab & office)

AddressA401, Bio-Medical Building, School of Life Sciences, Tsinghua University, Beijing, 100084, China

Lab Pagehttps://www.liulab-biology.org


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