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Da Mi

Email: mida@mail.tsinghua.edu.cn

Phone: 010-62793866


School of Life Sciences, Tsinghua University,  Assistant Professor

IDG/McGovern Institute for Brain, Tsinghua University, PI                

Center for Life Sciences, PI              


Education and Experience:

2001-2005  Nankai UniversityB.S.

2005-2008  Nankai UniversityM.Sc.

2008-2013  University of EdinburghPh.D.

2013-2015  University of EdinburghPostdoctoral Fellow

2015-2020  King’s College LondonPostdoctoral Fellow

2020-present  School of Life Sciences, Tsinghua University /Assistant Professor

2020-present IDG/McGovern Institute for Brain Research at Tsinghua University/PI

2020-present  Center for Life Sciences /PI


Research interest:

The cerebral cortex is the seat of higher-order brain functions. It consists of a multitude of specialized, precisely positioned and interconnected cell types that assemble into specialized neuronal circuits. One major goal of neuroscience is to understand how small pools of neural progenitor cells generate the vast diversity of neuronal cell types during brain development. Abnormal cortical development often translates into prominent neurodevelopmental disorders (NDDs) such as autism and schizophrenia. Our research group seeks to uncover cellular and molecular mechanisms regulating the emergence of neuronal diversity in the developing cerebral cortex. We also study the role of cellular heterogeneity in neurodevelopmental disorders (NDDs), with the ultimate goal of identifying cell types and their maturation stages that are closely associated with NDDs and understanding cell type-specific functions of disease susceptibility genes in cortical development.


Selected publications

1.  Mi, D., Li, Z., Lim, L., Li, M., Moissidis, M., Yang, Y., Gao, T., Hu, T.X., Pratt, T., Price, D.J., Sestan, N., and Marín, O. (2018). Early emergence of cortical interneuron diversity in the mouse embryo. Science. 360, 81-85.

2.  Mi D., Manuel M., Huang Y-T., Mason JO., and Price DJ (2018) Pax6 Lengthens G1 Phase and Decreases Oscillating Cdk6 Levels in Murine Embryonic Cortical Progenitors. Front. Cell. Neurosci. 12, 419.

3.  Lim, L. *, Mi, D. *, Llorca, A., and Marín, O. (2018). Development and Functional Diversification of Cortical Interneurons. Neuron. 100, 294-313.

4.  Manuel M. *, Mi D. *, Mason JO., and Price DJ. (2015). Regulation of cerebral cortical neurogenesis by the Pax6 transcription factor. Frontiers in cellular neuroscience. 9, 70.

5.  Mi, D., Carr, C.B., Georgala, P.A., Huang, Y.T., Manuel, M.N., Jeanes, E., Niisato, E., Sansom, S.N., Livesey, F.J., Theil, T., Hasenpusch-Theil, K., Simpson, T., Mason, J., and Price D.J. (2013). Pax6 Exerts regional control of cortical progenitor proliferation via direct repression of Cdk6 and Hypophosphorylation of pRb. Neuron. 78, 269–284.


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