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Xuebin Liao

Xuebin Liao


Research Area

1) Developing new approaches to cancer immunotherapy, including: TLR-related innate immune functions, epigenetic regulations of immune and cancer cells, and exploring combined cancer immunotherapy.

2) The mechanisms that regulate immune cell exhaustion, specifically, we discovered that HPK1 regulated T cell exhaustion through the NFkB-Blimp1 axis.

3) Structure-based drug discovery, in particular, discovery of inhibitors for HPK1, GLK and DAPK2.

4) Synthesis of bioactive natural products and development of new synthetic methods.


Selected Publications

  1. “Tumor Immunological Phenotype Signature-based High Throughput Screening for the Discovery of Combination Immunotherapy Compounds”, Wang, H.; Li, S.; Wang, Q.; Jin, Z.; Shao, W.; Gao, Y.; Li, L.; Lin, K.; Zhu, L.; Wang, H.; Liao, X.; Wang, D.* Sci. Adv. 2021, 7(4), eabd7851.
  2. Structure-Based Drug Design of Highly Potent Toll-Like Receptor 7/8 dual Agonists for Cancer Immunotherapy”, Wang, Z.; # Gao, Y.; # He, L.; # Sun, S.; Xia, T.; Hu, L.; Yao, L.; Wang, L.; Li, D.; Shi, H.; Liao, X.* J. Med. Chem. 2021, 64, 7507.
  3. “Hematopoietic progenitor kinase1 (HPK1) mediates T cell dysfunction and is a druggable target for T-cell based immunotherapies”, Si, J.; # Shi, X.; # Sun, S.; # Zou, B.; # Li, Y.; An, D.; Lin, X.; Gao, Y.; Long, F.; Pang, B.; Liu, X.; Liu, T.; Chi, W.; Chen, L.; Dimitrov , D. S.; Sun, Y.; Du, X.; Yin, W.; Gao, G.; Min, J.; Wei, L.; * Liao, X.* Cancer Cell 2020, 38, 551.
  4. “Enhancing KDM5A and TLR activity improves the response to immune checkpoint blockade”, Wang, L.;# Gao, Y.; # Zhang, G.; # Li, D.; # Wang, Z.; Zhang, J.; Hermida, L. C.; He, L.; Wang, Z.; Si, J.; Geng, S.; Ai, R.; Ning, F.; Cheng, C.; Deng, H.; Dimitrov, D. S.; Sun, Y.; Huang, Y.; Wang, D.; Hu, X.;* Wei, Z.; * Wang, W.;* Liao, X.* Sci Trans Med.  2020, 12, Issue 560, eaax2282.
  5. “Nickel-Catalyzed Cyanation of Aryl Halides and Hydrocyanation of Alkynes via C-CN Bond Cleavage and Cyano Transfer”, Chen, H.; Sun, S.; Liu, Y.; Liao, X. * ACS Catal. 2020, 10, 1397.




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