Wei Qin, PhD
Email: weiqin@mail.tsinghua.edu.cn
Group website: thu-qin-lab.org
Research interests
Our long-term research vision is to promote the revolution of proteomics from 1D to 4D, in order to describe each protein’s life trajectory in living cells. My lab will be focused on developing novel chemical and molecular tools, in combination with state-of-the-art proteomics, to simultaneously map dynamic timing, localization, function and interaction of proteomes, with the ultimate goal of better understanding essential mechanisms underlying the regulation of cellular physiology. Specifically, I have three major future directions to address different aspects of essential biological questions and lay the foundation for the eventual 4D proteomics.
1. Novel methods for spatiotemporally-resolved profiling of dynamic protein events, including protein trafficking, turnover and structural changes.
2. Novel methods for spatiotemporally-resolved profiling of molecular interactions.
3. Discovery of functional protein PTMs in host-pathogen interface. Selected publications：
(1) Wei Qin#; Joleen S. Cheah#; Charles Xu; James Messing; Brian D. Freibaum; Steven
Boeynaems; J. Paul Taylor; Namrata D. Udeshi; Steven A. Carr; Alice Y. Ting ; Dynamic mapping of proteome trafficking within and between living cells by TransitID, BioRxiv. 2023.
(2) Wei Qin; Samuel A. Myers; Dominique K. Carey; Steven A. Carr; Alice Y. Ting ;
Spatiotemporally-resolved mapping of RNA binding proteins via functional proximity labeling
reveals a mitochondrial mRNA anchor promoting stress recovery, Nature Communications, 2021,12(1).
(3) Wei Qin#; Yanling Zhang#; Huan Tang; Dongyang Liu; Ying Chen; Yuan Liu; Chu Wang ;
Chemoproteomic Profiling of Itaconylation by Bioorthogonal Probes in Inflammatory Macrophages, Journal of the American Chemical Society, 2020, 142(25): 10894-10898.
(4) Wei Qin; Ke Qin; Yanling Zhang; Wentong Jia; Ying Chen; Bo Cheng; Linghang Peng; Nan
Chen; Yuan Liu; Wen Zhou; Yan-Ling Wang; Xing Chen; Chu Wang ; S-glycosylation-based cysteine profiling reveals regulation of glycolysis by itaconate, Nature Chemical Biology, 2019, 15(10): 983-991.
(5) Wei Qin#; Ke Qin#; Xinqi Fan; Linghang Peng; Weiyao Hong; Yuntao Zhu; Pinou Lv; Yifei Du; Rongbing Huang; Mengting Han; Bo Cheng; Yuan Liu; Wen Zhou; Chu Wang; Xing Chen ; Artificial Cysteine S-Glycosylation Induced by Per-O-Acetylated Unnatural Monosaccharides during Metabolic Glycan Labeling, Angewandte Chemie International Edition, 2018, 57(7): 1817-1820.
(6) Wei Qin; Pinou Lv; Xinqi Fan; Baiyi Quan; Yuntao Zhu; Ke Qin; Ying Chen; Chu Wang; Xing
Chen ; Quantitative Time-resolved Chemoproteomics Reveals that Stable O-GlcNAc Regulates Box C/D snoRNP Biogenesis, Proceedings of the National Academy of Sciences of the United States of America, 2017, 114(33): 6749-6758.