Qiang Wang
Ph.D.
Assistant Professor
2006-2010 B.S., Northwest Agriculture & Forestry University
2010-2015 Ph.D., Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences
2015-2017 Postdoctoral fellow, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences
2017-2020 Postdoctoral fellow, University of California, San Francisco(UCSF), USA
2020-2021 Postdoctoral fellow, Beth Israel Deaconess Medical Center, Harvard Medical School, USA
2021-2023 Instructor, Beth Israel Deaconess Medical Center, Harvard Medical School, USA
2023,03- Tenure-Track Assistant Professor, School of Life Sciences, Tsinghua University
2023,03- PI, Tsinghua-Peking Center for Life Sciences
Research interest:
The activation of brown fat and beige fat works as one promising strategy for the intervention and treatment for obesity and metabolic disorders due to their roles in promoting thermogenesis and energy metabolism as well as improving glucose/lipid homeostasis. Using a variety of methods in biochemistry, molecular biology, cell biology, bioinformatics, metabolism and physiology, my lab focuses on deciphering the molecular machinery underlying the activation of brown fat or beige fat as well as the conversion between white fat and beige fat in the physiological and pathological conditions. Our research aims to provide new clues for prevention and treatment for obesity and type 2 diabetes.
Selected publications:
1. Wang Q., Li H., Tajima K., Verkerke A.R.P., Taxin Z.H., Hou Z., Cole J.B., Li F., Wong J., Abe I., Pradhan R. N., Yamamuro T., Yoneshiro T., Hirschhorn J.N., Kajimura S.*, Post-translational control of beige fat biogenesis by PRDM16 Stabilization. Nature. 2022; 609:151-158.
● News & Views: Horvath C, Scheele C. PRDM16 stability and metabolically healthy adipose tissue. Nat Metab. 2022 Sep 5 doi: 10.1038/s42255-022-00639-0
● Editors' Choice: Amy E. Baek. Blocking beige fat biogenesis. Sci Signal 15, eade6057, doi:10.1126/scisignal.ade6057
2. Yoneshiro T.#, Wang Q.#, Tajima K., Matsushita M., Maki H., Igarashi K., Dai Z., White P.J., McGarrah R.W., Ilkayeva O.R., Deleye Y., Oguri Y., Kuroda M., Ikeda K., Li H., Ueno A., Ohishi M., Kim K., Chen Y., Sponton C.H., Pradhan R.N., Majd H., Greiner V.J., Yoneshiro M., Brown Z., Chondronikola M., Takahashi H., Goto T., Kawada T., Sidossis L., Szoka F.C., McManus M.T., Saito M., Soga T., Kajimura S.*, BCAA catabolism in brown fat controls energy homeostasis through SLC25A44. Nature. 2019;572(7771):614-619.
● Clinical implications of basic research: Arany Z. Taking a BAT to the Chains of Diabetes. N Engl J Med. 2019 Dec 5;381(23):2270-2272.
● Research highlight: Morris A. Newly characterized mitochondrial BCAA transporter. Nat Rev Endocrinol. 2019 Nov;15(11):626.
● News & Views: Sun H, Wang Y. A new branch connecting thermogenesis and diabetes. Nat Metab. 2019 Sep;1(9):845-846.
3. Wang Q. # & Kajimura, S*. Naa10P puts a brake on PGC1alpha and fat browning. Nat Struct Mol Biol 26, 849-851 (2019).
4. Wang Q.#, Liu X.#*, Cui Y., Tang Y., Chen W., Li S., Yu H., Pan Y., Wang C.*, The E3 ubiquitin ligase AMFR and INSIG1 bridge the activation of TBK1 kinase by modifying the adaptor STING. Immunity. 2014 Dec 18;41(6):919-33. (Cover Story)
● Preview: Shu HB, Wang YY, Adding to the STING. Immunity. 2014 Dec 18;41(6):871-3
5. Wang Q.#, Huang L.#, Hong Z., Lv Z., Mao Z., Tang Y., Kong X., Li S., Cui Y., Liu H., Zhang L., Zhang X., Jiang L., Wang C.*, Zhou Q.*, The E3 ubiquitin ligase RNF185 facilitates the cGAS-mediated innate immune response. PLoS Pathog. 2017 Mar;13(3): e1006264.
Award:
American Diabetes Associations, postdoctoral fellowship (2021-2023)
Contact information：
E-mail：qwang123@mail.tsinghua.edu.cn