程功
电子邮件：gongcheng@mail.tsinghua.edu.cn
电话：＋86-10-62788494（办公室）
研究方向：
程功课题组主要从事虫媒病毒等新发、再发病毒性传染病感染传播机制与抗病毒免疫硏究。研究内容涉及登革病毒、乙型脑炎病毒、西尼罗病毒、基孔肯亚病毒等蚊媒病毒在哺乳动物宿主及节肢动物媒介中的感染机制，希望通过多种实验手段鉴定出与病毒感染高度相关的宿主/媒介靶点，并利用鉴定出的宿主/媒介靶点研发新型的干预策略，阻断虫媒病毒在自然界传播。目前，实验室聚焦的主要科学问题包括：1. 蚊媒病毒致病机制与免疫调控；2. 蚊媒病毒进化与传播机制；3. 媒介昆虫与微生物菌群互作；4. 昆虫行为生物学。
代表性科研论文 ：
1.Zhang LM, Wang DX, Shi PB, Li JZ, Niu JC, Chen JL, Wang G, Wu LJ, Chen L, Yang ZX, Li SS, Meng JX, Ruan FC, He YW, Zhao HL, Ren ZR, Wang YBN, Liu Y, Shi XL, Wang YF, Liu QY, Li JH, Wang PH, Wang JL #, Zhu YB #, Cheng G #. (2024) A naturally isolated symbiotic bacterium suppresses flavivirus transmission by Aedes mosquitoes. Science. 384: eadn9524.
2.Zhang H, Zhu YB, Liu ZW, Peng YM, Peng WY, Tong LQ, Wang JL, Liu QY, Wang PH, Cheng G #. (2022) A volatile from the skin microbiota of flavivirus-infected hosts promotes mosquito attractiveness. Cell. 185: 2510–2522.
3.Liu Y, Liu JY, Du SY, Shan C, Nie KX, Zhang RD, Li XF, Zhang RL, Wang T, Qin CF, Wang PH, Shi PY #, Cheng G #. (2017) Evolutionary enhancement of Zika virus infectivity in Aedes aegypti mosquitoes. Nature. 545: 482-486.
4.Yu X, Shan C, Zhu YB, Ma EH, Wang JL, Wang PH, Shi PY, Cheng G #. (2021) A mutation-mediated evolutionary adaptation of Zika virus in mosquito and mammalian host. Proceedings of the National Academy of the Sciences. 118: e2113015118.
5.Wu P, Sun P, Nie KX, Zhu YB, Shi MY, Xiao CG, Liu H, Liu QY, Zhao TY, Chen XG, Zhou HN, Wang PH, Cheng G #. (2019) A gut commensal bacterium promotes mosquito permissiveness to arboviruses. Cell Host & Microbe. 25: 101-112.
6.Zhu YB, Tong LQ, Nie KX, Wiwatanaratanabutr I, Sun P, Li QQ, Yu X, Wu P, Wu TS, Yu C, Liu QY, Bian ZQ, Wang PH, Cheng G #. (2019) Host serum iron modulates dengue virus acquisition by mosquitoes. Nature Microbiology. 4: 2405–2415.
7.Xiao XP, Yang LJ, Pang XJ, Zhang RD, Zhu YB, Wang PH, Gao GJ #, Cheng G #. (2017) A Mesh-Duox pathway regulates homeostasis in the insect gut. Nature Microbiology. 2: 17020.
8.Liu JY, Liu Y, Nie KX, Du SY, Qiu JJ, Pang XJ, Wang PH, Cheng G #. (2016) Flavivirus NS1 protein in infected host sera enhances viral acquisition by mosquitoes. Nature Microbiology. 1: 16087.
9.Pang XJ, Xiao XP, Liu Y, Zhang RD, Liu JY, Liu QY, Wang PH, Cheng G #. (2016) Mosquito C-type lectins maintain gut microbiome homeostasis. Nature Microbiology. 1: 16023.
10.Cheng G, Cox J, Wang PH, Krishnan MN, Dai JF, Qian F, Anderson JF, Fikrig E #. (2010) A C-Type Lectin collaborates with a CD45 phosphatase homolog to facilitate West Nile Virus infection of mosquitoes. Cell. 142: 714-725.
