陈雪梅

北京大学生命科学学院王宽诚讲席教授

生命科学联合中心PI

电子邮箱： xuemei.chen(at)pku(dot)edu(dot)cn

实验室主页：https://www.bio.pku.edu.cn/homes/Index/news_cont_jl/16/4.html

研究领域：

1. RNA 修饰的机制与功能：关注的RNA修饰包括假尿苷，5‘加帽等

2. 小RNA在植物热形态建成中的功能

研究兴趣（一段话介绍研究兴趣，方便读者理解）：

RNA修饰有170多种，但是我们对它们的认识还远远不够。RNA修饰是怎样写入的，怎样去除的，以及它们的分子及生物学功能亟待研究。课题组主要聚焦RNA 5‘端加帽修饰（例如NAD，FAD，ADPR，UDP-glucose）以及假尿苷修饰。课题组也研究小RNA的生物学功能，尤其在植物热形态建成（植物感受环境温度而调整发育从而适应温度）方面的功能。

代表性科研成果：

(* corresponding author)

1. Hao Hu*, Qiyue Zhang, Xuan Ma, Hsu-Feng Chu, Han Wang, Yiwen Guo, Yuze Bai, Qianyu Wang, Zehao Li, Jiayi Zhao, Huiyuan Lin, Chenjiang You, Xing Li, Liang Tong, Xuemei Chen*. (2026). Accurate Quantification and Transcriptome Profiling Reveal Abundant, Dynamic, and Translatable RNAs Capped with Dephospho-CoA. Nature Biotechnology, 10.1038/s41587-026-03040-4.

2. Xufeng Wang, Brandon H. Le, Ye Xu, Penglin Sun, Min Qiu, Yao Zhao, Lin Li, Min Wang, Kestrel Rogers, Yu Yu, Zhanyuan Zhang, Huixia Shou, Wenbo Ma and Xuemei Chen*. (2026). Soybean RNA polymerases IV and V repress defense response genes and plant immunity. Plant Cell, 10.1093/plcell/koag023.

3. Yu Yu*, Han Wang, Chenjiang You, and Xuemei Chen*. (2026). Plant microRNA maturation and function. Nat. Rev. Mol. Cell Biol. 27, 55-70.

4. Xufeng Wang, Dongli Yu, Jiancheng Yu, Hao Hu, Runlai Hang, Zachary Amador, Qi Chen, Jijie Chai, and Xuemei Chen*. (2024). Toll/interleukin-1 receptor (TIR) domain-containing proteins exhibit deNAMing activity towards NAD-capped RNAs. Nature Comm. 15: 2261.

5. Xuemei Chen* and Oded Rechavi*. (2021). Plant and animal small RNA communications between cells and organisms. Nature Rev. Mol. Cell Biol. 23, 85–203. https://doi.org/10.1038/s41580-021-00425-y.

6.Hao Hu, Nora Flynn, Hailei Zhang, Chenjiang You, Runlai Hang, Xufeng Wang, Huan Zhong, Zhulong Chan, Yiji Xia*, and Xuemei Chen*. (2021). SPAAC-NAD-seq, a sensitive and accurate method to profile NAD+-capped transcripts. PNAS 118 (13) e2025595118.