邓兴旺

北京大学现代农学院教授

北大-清华生命科学联合中心PI

电子邮件: deng(at)pku(dot)edu(dot)cn；

电话：+86-10-62983832

办公室主页：http://www.cls.edu.cn/info/1263/1022.htm

研究领域:光调控植物生长发育的分子机理，农业生物基因组与分子设计育种，主要农作物第三代杂交育种技术的开发与应用

研究兴趣：

一方面，以模式植物拟南芥为核心研究对象，持续深化光信号调控植物生长发育的分子机制研究。在前期大量研究成果的基础上，综合运用遗传学、生物化学与分子生物学、细胞生物学及结构生物学等多元技术手段，通过多维度的功能与结构分析，系统深入阐明光信号传导通路的精细调控机制，揭示植物适应环境光照的分子基础。另一方面，以水稻、小麦及其他重要经济作物为研究对象，整合遗传学、基因组学与生物信息学等多学科方法，结合基因编辑、全基因组选择育种等关键技术，开展重要农艺性状的分子模块解析与重组设计，系统推进“精确分子设计育种”理论与应用研究；同时，在主粮作物中开发并推广第三代作物杂交育种技术，培育具有自主知识产权的突破性杂交新品种。

代表性科研论文:

1. Deng, X.W., Matsui, M., Wei, N., Wagner, D., Chu, A.M., Feldmann, K.A., and Quail, P.H. (1992). COP1, an Arabidopsis regulatory gene, encodes a protein with both a zinc-binding motif and a G beta homologous domain. Cell 71, 791-801.

2. von Arnim, A.G., and Deng, X.W. (1994). Light inactivation of Arabidopsis photomorphogenic repressor COP1 involves a cell-specific regulation of its nucleocytoplasmic partitioning. Cell 79, 1035-1045.

3. Wei, N., Chamovitz, D.A., and Deng, X.W. (1994). Arabidopsis COP9 is a component of a novel signaling complex mediating light control of development. Cell 78, 117-124.

4. Chamovitz, D.A., Wei, N., Osterlund, M.T., von Arnim, A.G., Staub, J.M., Matsui, M., and Deng, X.W. (1996). The COP9 complex, a novel multisubunit nuclear regulator involved in light control of a plant developmental switch. Cell 86, 115-121.

5. Osterlund, M.T., Hardtke, C.S., Wei, N., and Deng, X.W. (2000). Targeted destabilization of HY5 during light-regulated development of Arabidopsis. Nature 405, 462-466.

6. Wang, H., Ma, L.G., Li, J.M., Zhao, H.Y., and Deng, X.W. (2001). Direct interaction of Arabidopsis cryptochromes with COP1 in light control development. Science 294, 154-158.

7. Schwechheimer, C., Serino, G., Callis, J., Crosby, W.L., Lyapina, S., Deshaies, R.J., Gray, W.M., Estelle, M., and Deng, X.W. (2001). Interactions of the COP9 signalosome with the E3 ubiquitin ligase SCFTIRI in mediating auxin response. Science 292, 1379-1382.

8. Feng, S., Martinez, C., Gusmaroli, G., Wang, Y., Zhou, J., Wang, F., Chen, L., Yu, L., Iglesias-Pedraz, J.M., Kircher, S., Schafer, E., Fu, X., Fan, L.M., and Deng, X.W. (2008). Coordinated regulation of Arabidopsis thaliana development by light and gibberellins. Nature 451, 475-479.

9. Wang, Z., Wang, W., Zhao, D., Song, Y., Lin, X., Shen, M., Chi, C., Xu, B., Zhao, J., Deng, X.W., and Wang, J. (2024). Light-induced remodeling of phytochrome B enables signal transduction by phytochrome-interacting factor. Cell 187, 6235-6250.e6219.

10. Liu, S., Li, K., Dai, X., Qin, G., Lu, D., Gao, Z., Li, X., Song, B., Bian, J., Ren, D., Liu, Y., Chen, X., Xu, Y., Liu, W., Yang, C., Liu, X., Chen, S., Li, J., Li, B., He, H., and Deng, X.W. (2025). A telomere-to-telomere genome assembly coupled with multi-omic data provides insights into the evolution of hexaploid bread wheat. Nat Genet 57, 1008-1020.