杜鹏
邮箱：pengdu@pku.edu.cn
实验室主页：https://dulab.pku.edu.cn
研究领域：
主要研究课题：
1, 鉴定未知的RNA调控元件及分析其对应的调控机制。
2, 研究RNA调控如何决定胚胎干细胞全能性及多能性状态的转化及分化命运。
3, 哺乳动物细胞中植物或微生物RNA调控通路的重建及其潜在应用。
研究兴趣：
研究集中在RNA生物学与干细胞生物学。我们综合运用传统的生物化学，分子生物学，结合高通量测序，基因组学，生物信息学等手段来分析和鉴定未知的RNA调控通路，研究相关RNA调控通路在胚胎干细胞的分化命运决定和早期胚胎发育中的功能。同时，我们致力于在动物细胞中重组植物或微生物中特异的RNA调控通路，并分析其潜在的对于基础科学研究和转化医学研究中的价值。
代表性研究成果：
1、Shiyu Li, Min Yang, Hui Shen, Li Ding, Xuehui Lyu, Kexin Lin, Jennie Ong, and Peng Du*.Capturing and maintenaning human cell totipotency through spliceosomal repression. Cell, 2024, 187(13):3284-3302.e23.
2、Xuehui Lyu, Yingzi Cui, Yinfei Kong, Min Yang, Hui Shen, Shuyun Liao, Shiyu Li, Chenrui An, Haoyi Wang, Zhe Zhang, Jennie Ong, Yan Li, Peng Du*. A transient transcriptional activation governs unpolarized-to-polarized morphogenesis during embryo implantation, Molecular Cell,2024,S1097-2765(24)00483-0.
3、Peng Du* and Jun Wu*. Hallmarks of totipotent and pluripotent stem cell states. Cell Stem Cell, 2024; 31:312-333.
4、Min Yang, Jennie Ong, Fanju Meng, Feixiang Zhang, Hui Shen, Kerstin Kitt, Tengfei Liu, Wei Tao and Peng Du*. Spatiotemporal insight of early pregnancy governed by immune-featured stromal cells. Cell, 2023; 186:4271-4288.
5、Yanxin Li, Zhongqiu Li, Changliang Wang, Min Yang, Ziqing He, Feiyang Wang, Yuehong Zhang, Rong Li, Yunxia Gong, Binhong Wang, Baoguang Fan, Chunyue Wang, Lei Chen, Hong Li, Peifu Shi, Nana Wang, Zhifeng Wei, Yan-Ling Wang, Lei Jin*, Peng Du*, Ji Dong*, and Jianwei Jiao*. Spatiotemporal transcriptome atlas reveals the regional specification of the developing human brain. Cell, 2023; 186:5892-5909.
6、Yingzi Cui, Ye Qi, Li Ding, Shuangjin Ding, Zonglin Han, Yangming Wang* and Peng Du*. miRNA dosage control in development and human disease. Trends in Cell Biology, 2023; DOI: https://doi.org/10.1016/j.tcb.2023.05.009
7、Ye Qi, Li Ding, Siwen Zhang, Shengze Yao, Jennie Ong, Yi Li, Hong Wu, and Peng Du* . A plant immune protein enables broad antitumor response by rescuing microRNA deficiency in cancers. Cell, 2022; 185:1888-1904.
8、Yanxin Li, Zhongqiu Li, Min Yang, Feiyang Wang, Yuehong Zhang, Rong Li, Qian Li, Yunxia Gong, Binhong Wang, Baoguang Fan, Chunyue Wang, Lei Chen, Hong Li, Jennie Ong, Zhaoqian Teng, Lei Jin*, Yan-Ling Wang*, Peng Du* and Jianwei Jiao*. Decoding the temporal and regional specification of microglia in the developing human brain. Cell Stem Cell, 2022; 29: 620-634.
9、Hui Shen, Min Yang, Shiyu Li, Jing Zhang, Bing Peng, Chunhui Wang, Zai Chang, Jennie Ong, and Peng Du*. Mouse totipotent stem cells captured and maintained through spliceosomal repression. Cell, 2021. 184:2843-2859.
10、Yingzi Cui, Xuehui Lyu, Li Ding, Lan Ke, Dechang Yang, Mehdi Pirouz, Ye Qi, Jennie Ong, Ge Gao, Peng Du*, and Richard Gregory*. Global miRNA dosage control of embryonic germ layer specification. Nature 2021; 593:602-606.
