杜鹏
北京大学生命科学学院博雅特聘教授
北大-清华生命科学联合中心PI
邮箱：pengdu (AT) pku.edu.cn
实验室主页：https://dulab.pku.edu.cn
研究领域：
1. 鉴定未知的RNA调控元件及分析其对应的调控机制。
2. 研究RNA调控如何决定胚胎干细胞全能性及多能性状态的转化及分化命运。
3. 哺乳动物细胞中植物或微生物RNA调控通路的重建及其潜在应用。
研究兴趣：
杜鹏研究员长期以来从事RNA调控和干细胞生物学的研究，深入解析RNA调控通路在干细胞命运决定和早期胚胎发育中的功能，提出的多项原创性基础研究和原始创新成果，代表了国际该领域发展的最前沿：课题组的研究集中在RNA生物学与干细胞生物学。我们综合运用传统的生物化学，分子生物学，结合高通量测序，基因组学，生物信息学等手段来分析和鉴定未知的RNA调控通路，研究相关RNA调控通路在胚胎干细胞的分化命运决定和早期胚胎发育中的功能。同时，我们致力于在动物细胞中重组植物或微生物中特异的RNA调控通路，并分析其潜在的对于基础科学研究和转化医学研究中的价值。
代表性研究成果：
1) Wei Zheng, Bing Peng, Zilin Chen, Kangwei Huang, Yueyao Qi, Huimin Niu, Hui Shen, Jun Wu, Jianwei Jiao*,and Peng Du*. Continuous modeling of primate embryogenesis from totipotency to early organogenesis. Cell, 2026 June 10，189, 1–17, doi.org/ 10.1016/ j.cell. 2026.05.025
2) Bing Peng , Qingyi Wang , Feixiang Zhang ,Hui Shen,and Peng Du*.Mouse totipotent blastomere-like cells model embryogenesis from zygotic genome activation to post implantation. Cell Stem Cell, 2025 Mar 6;32(3):391-408.e11. doi: 10.1016/ j.stem. 2024.12. 006.
3) Shiyu Li, Min Yang, Hui Shen, Li Ding, Xuehui Lyu, Kexin Lin, Jennie Ong, and Peng Du*.Capturing totipotency in human cells through spliceosomal repression.Cell, 2024 Jun 20;187(13):3284-3302.e23.doi: 10.1016/j.cell.2024.05.010.
4) Xuehui Lyu, Yingzi Cui, Yinfei Kong, Min Yang, Hui Shen, Shuyun Liao, Shiyu Li, Chenrui An, Haoyi Wang, Zhe Zhang, Jennie Ong, Yan Li, Peng Du*. A transient transcriptional activation governs unpolarized-to-polarized morphogenesis during embryo implantation. Molecular Cell,2024 Jul 25;84(14):2665-2681.e13.doi: 10.1016/j.molcel.2024.06.005.
5) Min Yang, Jennie Ong, Fanju Meng, Feixiang Zhang, Hui Shen, Kerstin Kitt, Tengfei Liu, Wei Tao and Peng Du*. Spatiotemporal insight of early pregnancy governed by immune-featured stromal cells. Cell, 2023 Sep 28;186(20):4271-4288.e24.doi: 10.1016/j.cell.2023.08.020.
6) Yanxin Li, Zhongqiu Li, Changliang Wang, Min Yang, Ziqing He, Feiyang Wang, Yuehong Zhang, Rong Li, Yunxia Gong, Binhong Wang, Baoguang Fan, Chunyue Wang, Lei Chen, Hong Li, Peifu Shi, Nana Wang, Zhifeng Wei, Yan-Ling Wang, Lei Jin*, Peng Du*, Ji Dong*, and Jianwei Jiao*. Spatiotemporal transcriptome atlas reveals the regional specification of the developing human brain. Cell, 2023; 186:5892-5909.
7) Yingzi Cui, Ye Qi, Li Ding, Shuangjin Ding, Zonglin Han, Yangming Wang* and Peng Du*. miRNA dosage control in development and human disease. Trends in Cell Biology, 2023; Pages 31-47
8) Ye Qi, Li Ding, Siwen Zhang, Shengze Yao, Jennie Ong, Yi Li, Hong Wu, and Peng Du* . A plant immune protein enables broad antitumor response by rescuing microRNA deficiency in cancers. Cell, 2022 May 26;185(11):1888-1904.e24.doi: 10.1016/j.cell.2022.04.030.
9) Hui Shen, Min Yang, Shiyu Li, Jing Zhang, Bing Peng, Chunhui Wang, Zai Chang, Jennie Ong, and Peng Du*. Mouse totipotent stem cells captured and maintained through spliceosomal repression. Cell, 2021 May 27;184(11):2843-2859.e20.doi: 10.1016/ j.cell. 2021.04.020.
10) Yingzi Cui, Xuehui Lyu, Li Ding, Lan Ke, Dechang Yang, Mehdi Pirouz, Ye Qi, Jennie Ong, Ge Gao, Peng Du*, and Richard Gregory*. Global miRNA dosage control of embryonic germ layer specification. Nature, 2021 May 5;593(7860):602-606. doi: 10.1038/ s41586 -021- 03524 -0.
