郭强
北京大学生命科学学院研究员/助理教授
生命科学联合中心PI
电子邮箱：guo.qiang（at）pku（dot）edu（dot）cn
研究领域：
冷冻电子断层扫描与原位结构生物学方法开发
细胞运动相关分子机器的组装
组织超微结构与病理机制
研究兴趣：
郭强研究员致力于利用冷冻电子断层扫描及多模态原位成像技术，研究细胞和组织天然环境中分子机器的三维结构、空间组织规律及其功能机制。通过融合成像、计算分析与定量建模，探索复杂生物体系中结构与功能的关联，揭示生理过程和疾病发生发展的分子基础。
代表性研究成果：
1. Jiang, W. *, Chen, C. *, Wang, X. *, Huang, W., Krokowski, D., Chen, Z., Xie, J., Su, Z., Hatzoglou, M. #, Taylor, D.J. #, and Guo, Q. # (2026) rRNA expansion segments mediate ribosome dimerization as a conserved stress response. Nucleic Acids Research, 54, gkag354.
2. Wu, L.*, Wang, J.*, Wang, Y.*, Yang, J., Yao, Y., Huang, D., Hu, Y., Xu, X., Wang, R., Du, W., Shi, Y., Li, Q., Liu, Lu., Zhu, Y., Wang, X., Guo, Q.#, Xu, L.#, Li, P.#, and Chen, X.# (2026). CLCC1 Governs Bilayer Equilibration at the Endoplasmic Reticulum to Maintain Cellular and Systemic Lipid Homeostasis. Nature. 652, 471-480.
3. Wu, Y.*, Wang, X.*, Meng, L.*, Liao, Z., Ji, W., Zhang, P., Lin, J.#, and Guo, Q.# (2025). Translation landscape of stress granules. Science Advances 11, eady6859.
4. Ma, S.*, Li, L.*, Li, Z.*, Luo, S.*, Liu, Q.*, Du, W., Qiu, B., Gui, M.#, Zhu, X.#, & Guo, Q.# (2025). In situ cryo-electron tomography reveals the progressive biogenesis of basal bodies and cilia in mouse ependymal cells. Nature Communications 16, 5932.
5. Wang, C.*, Jiang, W.*, Leitz, J.*, Yang, K., Esquivies, L., Wang, X., Shen, X., Held, R., Adams, D.J., Basta, T., Hampton, L., Jian, R., Jiang, L., Stowell, M.H.B., Baumeister, W., Guo, Q.#, Brunger, A.T.#, (2024). Structure and topography of the synaptic V-ATPase–synaptophysin complex. Nature 631, 899-904.
6. Liu, J.*, Li, Z.*, Li, M.*, Du, W., Baumeister, W., Yang, J.#, and Guo, Q.# (2023). Vimentin regulates nuclear segmentation in neutrophils. Proceedings of the National Academy of Sciences 120, e2307389120.
7. Li, W.*, Lu, J.*, Xiao, K.*, Zhou, M.*, Li, Y., Zhang, X., Li, Z., Gu, L., Xu, X., Guo, Q.#, Xu, T.#, Ji, W.#, (2023). Integrated multimodality microscope for accurate and efficient target-guided cryo-lamellae preparation. Nature Methods 20, 268-275.
8. Jiang, W., Wagner, J., Du, W., Plitzko, J., Baumeister, W., Beck, F.#, and Guo, Q.# (2022). A transformation clustering algorithm and its application in polyribosomes structural profiling. Nucleic Acids Research 50, 9001-9011.
9. Guo, Q.*, Bin, H.*, Cheng, J., Seefelder, M., Engler, T., Pfeifer, G., Oeckl, P., Otto, M., Moser, F., Maurer, M., Pautsch, A., Baumeister, W.#, Fernandez-Busnadiego, R.#, Kochanek, S.# (2018). The cryo-electron microscopy structure of huntingtin. Nature 555, 117–120.
10. Guo, Q., Lehmer, C., Martinez-Sanchez, A., Rudack, T., Beck, F., Hartmann, H., Hipp, M.S., Hartl, F.U., Edbauer, D.#, Baumeister, W.#, Fernandez-Busnadiego, R#. (2018) In Situ Structure of Neuronal C9orf72 Poly-GA Aggregates Reveals Proteasome Recruitment. Cell 172, 696-705.e612.
