张哲

北京大学药学院研究员/副教授

生命科学联合中心PI

电子邮件：zzhang01（at）pku（dot）edu（dot）cn

实验室主页：https://zzlab.zjwzht.com

研究领域：

1. 神经递质与关键代谢分子跨膜转运的分子机制；

2. 细胞增殖、分化与程序性死亡的信号调控机制；

3. 基于靶标蛋白结构的智能药物分子设计与筛选。

研究兴趣：

课题组长期致力于神经系统疾病及肿瘤相关的膜转运蛋白与受体蛋白的结构与药理机制研究。研究方向聚焦于溶质转运蛋白（SLC）介导的跨膜物质转运，以及膜受体介导的生长与发育信号转导，旨在从分子层面揭示其生理功能与病理机制，并针对关键靶点开展小分子药物筛选与设计，推动神经退行性疾病及癌症等领域的创新药物研发。

代表性研究成果：

1. Dong Zhou^#, Yang Zhang^#, Nanhao Chen^#, Shitang Huang, Chen Song^*, and Zhe Zhang^*; Structural basis of G6P/Pi transport and inhibition in SLC37A4; Nat. Struct. Mol. Biol.; 2026, 33(1): 123-133.

2. Dong Zhou, Nanhao Chen, Shitang Huang, Chen Song, and Zhe Zhang^*; Mechanistic insights into the acetyl-CoA recognition by SLC33A1; Cell Discov.; 2025, 11(1): 36.

3. Yanyi Song^#, Shuyi Jian^#, Junlin Teng, Pengli Zheng^*, and Zhe Zhang^*; Structural basis of human VANGL-PRICKLE interaction; Nat. Commun.; 2025, 16(1):132.

4. Yang Zhang^#, Fei Dai^#, Nanhao Chen^#, Dong Zhou, Chia-Hsueh Lee^*, Chen Song^*, Yixiao Zhang^*, and Zhe Zhang^*; Structural insights into VAChT neurotransmitter recognition and inhibition; Cell Res.; 2024, 34(9): 665-668.

5. Yu Dang^#, Tianyi Zhang^#, Shabareesh Pidathala^#, Guopeng Wang^#, Yijie Wang^#, Nanhao Chen^#, Chen Song, Chia-Hsueh Lee^*, and Zhe Zhang^*; Substrates and drug recognition mechanisms of SLC19A3; Cell Res.; 2024, 34(6): 458-461.

6. Shabareesh Pidathala^#, Shuyun Liao^#, Yaxin Dai^#, Xiao Li, Changkun Long, Chi-Lun Chang, Zhe Zhang^*, and Chia-Hsueh Lee^*; Mechanisms of neurotransmitter transport and drug inhibition in human VMAT2; Nature; 2023, 623(7989): 1086-1092.

7. Xue Bai^#, Pengyu Sun^#, Xinghao Wang^#, Changkun Long^#, Shuyun Liao^#, Song Dang, Shangshang Zhuang, Yongtao Du, Xinyi Zhang, Nan Li, Kangmin He^*, and Zhe Zhang^*; Structure and dynamics of the EGFR/HER2 heterodimer; Cell Discov.; 2023, 9(1): 18.

8. Yu Dang, Dong Zhou, Xiaojuan Du, Hongtu Zhao, Chia-Hsueh Lee, Jing Yang, Yijie Wang, Changdong Qin, Zhenxi Guo, and Zhe Zhang^*; Molecular mechanism of substrate recognition by folate transporter SLC19A1; Cell Discov.; 2022, 8(1): 141.

9. Zelin Duan^#, Xuezhen Lin^#, Lixia Wang^#, Qiuxin Zhen, Yuefeng Jiang, Chuxin Chen, Jing Yang, Chia-Hsueh Lee, Yan Qin, Ying Li, Bo Zhao^*, Jianchuan Wang^*, and Zhe Zhang^*; Specificity of TGF-β1 signal designated by LRRC33 and integrin αVβ8; Nat. Commun.; 2022, 13(1): 4988.

10. Yuefeng Jiang, Tingting Liu, Chia-Hsueh Lee, Qing Chang, Jing Yang^*, and Zhe Zhang^*; The NAD⁺-mediated self-inhibition mechanism of pro-neurodegenerative SARM1; Nature; 2020, 588(7839): 658-663.