张迪
北京大学生命科学学院研究员/助理教授
生命科学联合中心PI
电子邮件：zhangdi（AT）pku.edu.cn
实验室主页: http://di-zhang-lab.com
个人主页：https://scholar.google.com/citations?user=vU5Sz28AAAAJ&hl=en
研究领域：
1. 代谢物的信号调控功能 (新型修饰、别构调节)；
2. 代谢酶的信号调控功能；
3. 细胞活动的代谢适应与代谢调控新机制，及其在生理病理中的作用；
研究兴趣：
基于代谢信号调控的细胞行为整合新视角：代谢不仅为细胞提供能量和构建模块，还通过多种方式调控细胞功能，与细胞的各类生命活动紧密相连。本研究团队致力于揭示代谢如何通过复杂机制调控关键的生理活动，从而帮助细胞适应环境，并探究代谢途径异常在重大疾病发生发展中的作用机制。我们综合运用经典的生物化学、细胞与分子生物学技术，并结合最新的多组学分析方法，在国际上首次报道了多种由细胞代谢物驱动的新型蛋白质修饰，包括由乳酸介导的赖氨酸乳酰化以及由酮体介导的赖氨酸β-羟基丁酰化等。
代表性研究成果：
(*Co-first author, # Corresponding author)
(1) Ren H, Tang Y, Zhang D#. (2025).The emerging role of protein l-lactylation in metabolic regulation and cell signalling. Nat Metab 7: 647–664.
(2) Zhang D#, Gao J, Zhu Z, Mao Q, Xu Z, Singh PK, Rimayi CC, Moreno-Yruela C, Xu S, Li G, Sin YC, Chen Y, Olsen CA, Snyder NW, Dai L, Li L, Zhao Y. (2025). Lysine L-lactylation is the dominant lactylation isomer induced by glycolysis. Nat Chem Biol. 21(1): 91–99.
(3) Ren H, Zhang D#. (2024). Lactylation constrains OXPHOS under hypoxia. Cell Res. 34(2): 91-92.
(4) Gao J, Sheng X, Du J, Zhang D, Han C, Chen Y, Wang C, Zhao Y. (2023). Identification of 113 new histone marks by CHiMA, a tailored database search strategy. Sci Adv. 9(14): eadf1416.
(5) Moreno-Yruela C, Zhang D*, Wei W, Bæk M, Liu W, Gao J, Danková D, Nielsen AL, Bolding JE, Yang L, Jameson ST, Wong J, Olsen CA, Zhao Y. (2022). Class I histone deacetylases (HDAC1-3) are histone lysine delactylases. Sci Adv. 8(3): eabi6696.
(6) Huang H, Zhang D*, Weng Y, Delaney K, Tang Z, Yan C, Qi S, Peng C, Cole PA, Roeder RG, Zhao Y. (2021). The regulatory enzymes and protein substrates for the lysine β-hydroxybutyrylation pathway. Sci Adv. 7(9): eabe2771.
(7) Zhang D*, Tang Z*, Huang H, Zhou G, Cui C, Weng Y, Liu W, Kim S, Lee S, Perez-Neut M, Czyz D, Hu R, Ye Z, He M, Zheng YG, Shuman H, Ding J, Dai L, Ren B, Robert RG, Becker L, Zhao Y. (2019). Metabolic regulation of gene expression by histone lactylation. Nature. 574: 575-580.
(8) Huang H, Zhang D, Wang Y, Perez-Neut M, Han Z, Zheng YG, Hao Q, Zhao Y. (2018). Lysine benzoylation is a histone mark regulated by SIRT2. Nat Commun. 9(1): 3374.
(9) Sabari BR*, Zhang D*, Allis CD, Zhao Y. (2017). Metabolic Regulation of Gene Expression through Differential Histone Acylation. Nat Rev Mol Cell Biol. 18(2): 90-101.
(10) Xie Z*, Zhang D*, Chung D*, Tang Z, Huang H, Dai L, Qi S, Li J, Colak G, Chen Y, Xia C, Peng C, Ruan H, Kirkey M, Wang D, Jensen LM, Kwon OK, Lee S, Pletcher SD, Tan M, Lombard DB, White KP, Zhao H, Li J, Roeder RG, Yang X, Zhao Y. (2016). Metabolic Regulation of Gene Expression by Histone Lysine beta-hydroxybutyrylation. Mol Cell. 62(2): 194-206.
