曾泽贤
电子邮件: zexianzeng@pku(dot)edu(dot)cn
实验室主页：http://cqb.pku.edu.cn/zenglab/
研究方向：
围绕“肿瘤微环境中免疫细胞空间分布及其可调控性”这一问题，课题组干湿结合，开展了深入的多学科交叉研究，已独立自主开发多项关键技术：空间免疫技术，包括空间单细胞高通量基因编辑与筛选技术、空间T/BCR测序技术、空间微生物组测序技术等；人工智能算法，包括计算病理学大模型、基于空间转录组的细胞重构扩散模型等。体内外基因编辑技术，包括人类与小鼠系统原代T细胞编辑技术，基于造血干细胞移植的体内CROP-Seq技术，肝脏内巨噬细胞编辑技术等。
代表性科研论文(*通讯)：
2026
1. Zhang H, Zhang Z, Wang P, Xu T, Chen X, Zhao Y, Lin S, Cai W, Ren P, Luo C, Zhang P, Wang Y, Hou S, Zhao Y, Zeng H, Liu Z, Wang C, Gao Z, Feng Y*, Pan D*, Zeng Z*. Uncovering spatially resolved functional genomics with CRISPR screen sequencing. Cell. 2026, 04.049
2. He Y, Zhao Y, Zhang R, Yang H, Zhang Z, Ren P, Luo C, Zhang P, Zhang Z, Hou S, Bu Z*, Luo Y*, Pan D*, Zeng Z*. DISSECT integrates cytological images and spatial transcriptomics for cell segmentation. Nature Computational Science, 2026, (accepted in principle)
3. Wang S, Hou S, Luo C, Zhang H, Jin Y, Zhang R, Zhao Y, Xiong X, Guo R, Wang C, Bao Y, Wen L, Pan D, Ye Y*, Zeng Z*, Gao Z*. Arid3b suppresses CD8+ T cell infiltration and function in MSS colorectal cancer1 via Runx3. Nature Communications. 2026 03.18
4. Lin K, Zhang N, Zhang Z, Zhou X, Qiao B, Yang D, Guo J, Zeng Z*, Xie X*, Zhuang B*. High-resolution spatial transcriptomics identifies Insufficient Radiofrequency ablation induces hepatocellular carcinoma progression via CEBPD/CXCL2 axis. Hepatology, 2026, (in press)
5. Zhan X, Huang M, Zhang Y, Liu Z, Liu C, Guo Y, … Zuo Li, Wang H, Liu X, Wu Z, Zhou J*, Zeng Z*, Feng Y*. Uncovering ectopic GC-like niches for tumor reactive lymphocyte priming in lung adenocarcinoma using Stereo-XCR-seq. Nature Communications. 2026 (in press)
6. Jin Y, Zheng W, Zhang R, Hou S, Luo C, Ren P, Pan D, Luo C*, Zeng Z*. The aryl hydrocarbon receptor (AHR) drives human leukocyte antigen (HLA)-II expression in human melanoma. Journal of Experimental & Clinical Cancer Research. 2026 Feb 20
7. Wang H, Zhao F, Li Y, Wang P, Wang Y, Ren P, Li C, Zheng H, Zeng Z*, Pan D*. ZNF296 drives immune evasion in epithelial cancers by repressing immune stimulatory genes. Cancer Research. 2026 Jan 2;86(1):116-130
8. Sun Q, Zhao Y, Qiao S, Wang K, Lu C, Zhang Z, Guo Z, Ding Z, Wang C, Li J, Liu T, Zeng Z*, Liu Z*. Boron neutron capture therapy preserves immune cells and induces robust anti-tumour immunity in preclinical mouse models. Nature Communications. 2026 17, 1229.
2025
1. Luo C, Zhang R, Guo R, Wu L, Xue T, He Y, Jin Y, Zhang P, Ye S, Li X, Li D, Zhang W, Wang C, Lai L, Pan-Hammarström Q, Wucherpfennig K, Gao Z*, Pan D*, Zeng Z*. Integrated computational analysis identifies therapeutic targets with dual action in cancer cells and T cells. Immunity. 2025 Mar 11;58(3):745-765.e9..
2. Ren P, Zhang R, Wang Y, Zhang P, Luo C, Wang S, Li X, Zhang Z, Zhao Y, He Y, Zhang H, Li Y, Gao Z, Zhang X, Zhao Y, Liu Z, Meng Y*, Zhang Z*, Zeng Z*. Systematic benchmarking of high-throughput subcellular spatial transcriptomics platforms across human tumors.Nature Communications.2025 Oct 17;16(1):9232.
3. Zhou X, Xu T, Li C, He Y, Hu Y, Gong H, Li J, Jiang H, Wen L, Fu Y, Zeng Z*, Pan D*. Potentiating anti-tumor immunity by re-engaging immune synapse molecules. Cell Reports Medicine. 2025 Feb 14:101975.
4. Li Y, Ding Y, Dennis S, Hutch MR, Zhou J, Zhou Y, Li Y, Pillai M, Ghotbaldini S, Garcia MA, Broad MS, Mao C, Dulai PS, Cheng F, Zeng Z*, Luo Y*.SOAR elucidates biological insights and empowers drug discovery through spatial transcriptomics. Science Advances.2025 Jun 13;11(24):eadt7450.
5. Lu Y, Luo C, Huang L, Wu G, Zhong L, Chu J, Wang F*, Zeng Z*, Pan D*. Functional Genetic screens reveal key pathways instructing the molecular phenotypes of tumor-associated macrophages. Cancer Immunology Research.2025 Dec 2;13(12):2054-2074.
6. Zhao J, Li X, Li X, Ren P, Wu Y, Gong H, Wu L, Huang J, Wang S, Guo Z, Chen M, Zeng Z*, Pan D*. Targeting plasticity in the pyrimidine synthesis pathway potentiates macrophage-mediated phagocytosis in pancreatic cancer models. Journal of Clinical Investigation (JCI). 2025 Nov 17;135(22):e193370.
7. Tang K, Wu L, Hu Y, Xue T, Jin Y, Zhou X, Luo C, Zhao Y, Tong L, Dai J, Feng D, Zeng Z*, Pan D*.Perturbation of calreticulin potentiates CD8+ T cell-mediated antitumor immunity. Journal of Experimental Medicine (JEM).2025 Oct 6;222(10):e20242360.
2023
1. Wu L, Jin Y, Zhao X, Tang K, Zhao Y, Tong L, Xiong K, Luo C, Zhu J, Wang F, Zeng Z*, Pan D*. Tumor aerobic glycolysis confers immune evasion through modulating sensitivity to T cell-mediated bystander killing via TNF-α. Cell Metabolism. 2023 Sep 5;35(9):1580-1596.e9
