中心PI


张蔚

北京大学生命科学学院 教授

生命科学联合中心PI

电子邮箱:weizhangvv(AT)pku.edu.cn

实验室主页:https://www.weizhanglab.net/

研究领域:演化基因组学和群体遗传学

研究兴趣:

我们的研究致力于解决一些重要的演化问题,例如物种形成、适应和基因渐渗。具体而言,我们的工作侧重于整合实验与计算方法,以研究模式生物和非模式生物中的适应性基因渐渗、探索昆虫和蜘蛛的反捕食适应机制,例如拟态、警戒色和伪装,及由上述研究拓展的基于节肢动物极端适应性状的仿生和转化医学研究、开发面向非模式生物的分析算法和实验方法。

代表性科研成果:

1. Liao M*, Chen X*, Zhao D*, Yuan D, Huang D, Yan Z, Huang L, Ni J, Ma Q, Pan Y, Hu Y, Moczek AP, Zhang W#, Ren C#, Li S#. Rewiring the DSX-E93 axis underlies convergent female-specific wing regression. Nat. Ecol. Evol. In press

2. Li F*, Lv Y*, Bian C, Perrin QM, Zhang Y, Wang Y, Cao L, Yu L, Guo S, Zhang W#, Shi Q#, Li D#. Transition from land to sea: Comparative genomics illuminates the adaptive evolution of the intertidal spider. Mol. Ecol. Resour. 2026 May;26(4):e70147.

3. Li F*, Yang H*, Zhang Y*, Wang S, Gu Q, Wu M, Jin P, Huang X, Zhong Y, Huang X, Lin Y, Guo X, Li Y, Zhang W#, Li S#. An ancient genome duplication event drives the development and evolution of spinnerets in spiders. Sci. Adv. 2026 Jan 16;12(3):eadw2173.

4. Luan Y#*, Zhang Y*, Li J, Zhu J, Lei Y, Hu Y, Xin Z, Xie T, Zheng J, Lin Y, Shen J, Cao Y, You X, Xi J, Wu J, Liu W, Zhang X, Zheng Y, Lohman DJ, Shi L#, Zhang W#. Mechanisms of aristolochic acid resistance in specialist butterflies and evolutionary insights for potential protective pathways. Adv. Sci. 2026 Jan 4:e18072.

5. Pei XJ*, Zhao D*, Luo J, Jia PY, Luo Y, Yuan DW, Hou WX, Zhang ZF, Huang DY, Ni JX, Gao HZ, Chen Z, Luan YX, Chen XX#, Zhang W#, Li S#. Redboy confers programed body color transition in orchid mantis. Nat. Ecol. Evol. 2025 Jul;9(7):1120–1137.

6. Zhang Y*, Zhu Q*, Shao Y, Jiang Y, Ouyang Y, Zhang L#, Zhang W#. Inferring historical introgression with deep learning. Syst. Biol. 2023 Nov 1;72(5):1013–1038.

7. Teng D, Zhang W#. The diversification of butterfly wing patterns: Progress and prospects. Curr. Opin. Insect Sci. 2023 Nov 3:61:101137.

8. Wu N, Evans E, van Schooten B, Meléndez-Rosa J, Ortiz Y, Planas Soto-Navarro SM, Van Belleghem SM, Counterman BA, Papa R#, Zhang W#. Widespread gene expression divergence in butterfly sensory tissues plays a fundamental role during reproductive isolation and speciation. Mol. Biol. Evol. 2022 Nov 3;39(11):msac225.

9. Wang S*, Teng D*, Li X*, Yang P, Da W, Zhang Y, Zhang Y, Liu G, Zhang X, Wan W, Dong Z, Wang D, Huang S, Jiang Z, Wang Q, Lohman DJ, Wu Y, Zhang L, Jia F, Westerman E, Zhang L, Wang W, Zhang W#. The evolution and diversification of oakleaf butterflies. Cell 2022 Aug 18;185(17):3138–3152.

10. Zhang Y*, Teng D*, Lu W*, Liu M*, Zeng H, Cao L, Southcott L, Potdar S, Westerman E, Zhu AJ#, Zhang W#. A widely diverged locus involved in locomotor adaptation in Heliconius butterflies. Sci. Adv. 2021 Aug 4;7(32):eabh2340.