赵扬

北京大学临床医学高等研究院研究员

北大-清华生命科学联合中心PI

邮箱：yangzhao（AT）pku.edu.cn

实验室主页：https://iacm.bjmu.edu.cn/szdw/kxbswyxgcx1/dsdw2/zhaoyang.html

研究领域：干细胞生物学、再生医学、细胞重编程

研究兴趣：

1. 心脏、肝脏的细胞命运决定与再生修复

2. 心脏、肝脏复合类器官构建及药物筛选

3. 基于药物扰动图谱和AI虚拟细胞技术研究细胞命运调控及重编程

代表性研究成果（不超过10篇）：

1. Transcriptome-guided development of a fibrosis-reversal compound reduces skin scarring and allows regeneration via mitochondrial uncoupling. Chun-Ye Chen#， Ruilin Xu#， Mingguang Mo， Jiahao Wu， Jun Chi ， Zhang-Rui Wu，Yi Wang，Xin-Cao Zhong，Xiao-Ying Lin，Yang Liu，Jingdong Wu，Huaan Fang，Hongli Jia，Hongsen Bi*，Yong Yang*，Wei-Qiang Tan*，Yang Zhao*. Cell Reports Medicine. 2026 May 19;7(5):102821.

2. Perturb-seq uncovers pathological obstacles to direct cardiac reprogramming in vivo. Yihong Cai#, Yang Yang#, Junbo Yang#, Ruohan Ding, Qihan Zhang, Xin Dang, Chenxuan Li, Yang Zhao*. Cell Stem Cell. 2026 May 7;33(5):784-799.

3. Macrophages suppress cardiac reprogramming of fibroblasts in vivo via IFN-mediated intercellular self-stimulating circuit. Hao Wang^#, Junbo Yang^#, Yihong Cai,Yang Zhao*. Protein & Cell.2024 Dec 2;15(12):906-929.

4. Osr1-mediated mesothelial transition of liver mesenchymal cells exacerbates fibrotic liver damage. Xinxin Nian, Pengyan Lin, Yunfei Bai, Donglin Yu, Xinyan Yang, Bin Zhou, Jie Gao, Yang Zhao*. Molecular Therapy. 2024 Sep 4;32(9):2984-2991.

5. An improved factor combination for in vivo reprogramming of cardiac myofibroblast to cardiomyocyte-like cell with dual recombinase tracing. Jingdong Wu; Hong Zhao; Yanmeng Tao; Chunyan Yang; Yang Yang; Bin Zhou*; Yang Zhao*. Circulation. 2023 Nov 21;148(21):1728-1731. doi: 10.1161/CIRCULATIONAHA.122.062810.

6. A live-cell image-based machine learning strategy for reducing variability in PSC differentiation systems. Xiaochun Yang^#; Daichao Chen^#; Qiushi Sun^#; Yao Wang; Yu Xia; Jinyu Yang; Chang Lin; Xin Dang; Zimu Cen; Dongdong Liang; Rong Wei; Ze Xu; Guangyin Xi; Gang Xue; Can Ye; Li-Peng Wang; Peng Zou; Shi-Qiang Wang; Pablo Rivera-Fuentes; Salome Püntener; Zhixing Chen; Yi Liu*; Jue Zhang*; Yang Zhao*. Cell Discovery. 2023, 9(1): 53

7. Transcriptome-based chemical screens identify CDK8 as a common barrier in multiple cell reprogramming systems. Jun Li^#; Yunfei Bai^#; Yang Liu; Zhongya Song; Yong Yang; Yang Zhao*. Cell Reports. 2023, 42(6): 112566

8. Direct chemical induction of hepatocyte-like cells with capacity for liver repopulation. Yunfei Bai; Zhenghao Yang; Xiaochan Xu; Wanqiu Ding; Juntian Qi; Feng Liu; XiaoXiao Wang; Bin Zhou; Wenpeng Zhang; Xiaomei Zhuang; Guanglu Li; Yang Zhao*. Hepatology. 2023, 77(5):1550-1565.

9. A XEN-like state bridges somatic cells to pluripotency during chemical reprogramming. Yang Zhao*^{, #}; Ting Zhao^#; Jingyang Guan^#; Xu Zhang^#; Yao Fu^#; Junqing Ye^#; Jialiang Zhu; Gaofan Meng; Jian Ge; Susu Yang; Lin Cheng; Yaqin Du; Chaoran Zhao; Ting Wang; Linlin Su; Weifeng Yang; Hongkui Deng*. Cell. 2015, 163(7): 1678-1691.

10. Pluripotent stem cells induced from mouse somatic cells by small-molecule compounds. Pingping Hou^#; Yanqin Li^#; Xu Zhang^#; Chun Liu^#; Jingyang Guan^#; Honggang Li^#; Ting Zhao; Junqing Ye; Weifeng Yang; Kang Liu; Jian Ge; Jun Xu; Qiang Zhang; Yang Zhao*; Hongkui Deng*. Science. 2013, 341(6146): 651-654